Neuropsychological deficits in the areas of learning, memory, attention, and abstraction abilities have been associated with cocaine dependence, especially during the period of early abstinence. Although cocaine users tend to be multidrug...
moreNeuropsychological deficits in the areas of learning, memory, attention, and abstraction abilities have been associated with cocaine dependence, especially during the period of early abstinence. Although cocaine users tend to be multidrug users, few studies have focused on the combined effect of alcohol and cocaine on neuropsychological functioning. Consistent with prior research, results from the current study indicated that cocaine-dependent subjects showed a significantly greater degree of neuropsychological impairment as compared to controls. In addition, cocaine-dependent subjects with a history of alcohol disorder showed less memory impairment but similar impairments in attention and overall neuropsychological functioning as cocaine subjects with no such history. The vasodilatation produced by alcohol may attenuate some of the vasoconstriction and neurotoxic effects of cocaine, accounting for the fewer deficits in this group (Am J Addict 2005;14:166-178) C ocaine, in particular crack cocaine, is considered to be the most commonly abused psychoactive substance in the United States, 1 with an estimated half million Americans using cocaine weekly. Studies with cocaine abusers have suggested cognitive reductions in learning and memory, 3-7 attention and concentration, 4,8 and visuospatial skills. These deficits have been reported during the initial period of abstinence 1,4,10 and may persist well beyond the period of acute withdrawal. In