Turk Pediatri Arsivi-turkish Archives of Pediatrics, Oct 10, 2018
Cutis laxa tip1b is a rare autosomal recessive disorder caused by FBLN 4 mutation and primarily c... more Cutis laxa tip1b is a rare autosomal recessive disorder caused by FBLN 4 mutation and primarily characterized by vascular anomalies. Herein, we present five patients who are the members of the same family. The primary cardiac findings of these patients were giant aortic aneurysms. One 2.5-year-old patient with a massive aneurysm of the ascending aorta died as a result of compression to the heart chambers, trachea, and bronchi. The bentall procedure was performed in three of our patients who are under follow-up. One patient is still under clinical follow-up without surgery. After the diagnosis of the first patient, a genetic study was performed in which FBLN 4 mutations were investigated. Four new patients were detected during genetic screening of the family. Other 29 family members were screened bur were negative in physical examinations and echocardiography. Pedigree is important for early diagnosis of genetic diseases in asymptomatic individuals.
Objective: Transvenous permanent cardiac pacing (TPCP) has become a frequently used therapeutic m... more Objective: Transvenous permanent cardiac pacing (TPCP) has become a frequently used therapeutic modality in children. The purpose of this study was to evaluate the outcome of pediatric TPCP regarding problems and complications. Methods: Records of 155 patients (mean age 9.2+/-4.7 years) who underwent implantation of TPCP between 1993 and 2003 were reviewed retrospectively. Indications for pacing included atrioventricular block in 76% and sinus node dysfunction in 22% patients. In 92 patients, bradyarrhythmia was secondary to cardiac surgery. Percutaneous subclavian puncture was used for lead implantation in 96% of patients. Pacemakers were placed to the right side of the chest in 84% and in the subpectoral area in 68%. Pacing modes were VVIR in 72%, VDD in 13%, AAIR in 8%, and DDD in 7% of patients at the initial implantation time. Of all electrodes, 95% had steroid elution and 53% had an active fixation mechanism. Mean follow-up period was 37+/-28 (1-120) months. Results: Forty-five (29%) patients had 21 minor and 45 major complications. Forty-four of 76 revisions were due to lead problems and battery extraction. Most of the lead problems were dislodgment and stretching (n=14). Kaplan Meier analysis of lead survival did not show any difference between lead types. During the follow-up, there were three sudden unexpected deaths. Conclusions: In children, TPCP can be used safely and effectively. Although, complications are possible and sometimes lead or generator revision may be necessary, long-term outcome is favorable.
Bilateral ductal stenting should be performed in cases of discontinuity of the pulmonary branches... more Bilateral ductal stenting should be performed in cases of discontinuity of the pulmonary branches and pulmonary atresia. Performing this procedure via the carotid artery in small infants can be very difficult and challenging. We present a case of bilateral ductal stenting via both the femoral and carotid arteries in a little child with tetralogy of Fallot with pulmonary atresia and a nonconfluent pulmonary artery and bilateral ductus arteriosus.
World Journal for Pediatric and Congenital Heart Surgery, Feb 6, 2016
One of the most rare and dangerous complications of a modified Blalock-Taussig shunt involves the... more One of the most rare and dangerous complications of a modified Blalock-Taussig shunt involves the formation of a pseudoaneurysm. A pseudoaneurysm may rupture or may result in other adverse events including compression of mediastinal structures or collapse of the underlying lung parenchyma. Shunt-related pseudoaneurysm may be associated with shunt occlusion, bacteremia, or pulmonary hemorrhage. We describe two cases complicated by large pseudoaneurysm formation, following systemic-to-pulmonary artery shunt operations. The patients in question had recurrent pulmonary hemorrhage. Both underwent successful placement of covered coronary artery stents.
Objective: Conotruncal heart defects represent 10%-15% of congenital heart diseases and mostly in... more Objective: Conotruncal heart defects represent 10%-15% of congenital heart diseases and mostly include tetralogy of Fallot, pulmonary atresia with ventricular septal defect, truncus arteriosus, and interrupted aortic arch. Methods: This study aimed to investigate the prevalence of 22q11.2 deletion (Del22) with fluorescent in situ hybridization analysis among children followed with conotruncal heart defects. In 104 cases with conotruncal heart defects, the 22q11.2 region was screened for deletion through the fluorescent in situ hybridization analysis using a probe specific to this region. Results: The fluorescent in situ hybridization analysis performed in patients with conotruncal heart defects showed that Del22 was present in 3 cases in Group I (70 pts) with isolated cardiopathy (4.3%), 2 cases in Group II (29 pts) with cardiopathy + dysmorphism (6.9%), 2 cases in Group III (2 pts) with cardiopathy + immunodeficiency + dysmorphism (100%), and 1 case in Group IV (3 pts) with cardiopathy + immunodeficiency (33.3%) (P < .05). Eight (7.5%) of 104 patients with conotruncal heart defects were found to have Del22. Conclusions: The results obtained from the present study are compatible with the literature. The clinical manifestation of Del22 is extremely variable. With additional abnormalities such as immunodeficiency and dysmorphic features, Del22 positivity was increasing statistically.
The internal jugular vein is not a typical vascular access line during the percutaneous closure o... more The internal jugular vein is not a typical vascular access line during the percutaneous closure of an atrial septal defect. We report the closure of a double atrial septal defect with a single device, using a transjugular venous approach, in a child with an inferior vena cava obstructed by a thrombosis due to previous cardiac catheterization. That the transjugular venous approach can be used as a possible alternative during the transcatheter closure of an atrial septal defect in children, when the inferior vena cava access is not possible.
Kalp hızı değişkenliği (KHD) kalbin nöral aktivitesini değerlendiren non invaziv bir indekstir. D... more Kalp hızı değişkenliği (KHD) kalbin nöral aktivitesini değerlendiren non invaziv bir indekstir. Diyabetli yetişkinlerde çeşitli kalp hızı değişkenliği anormallikleri tespit edilmiştir. Bununla birlikte diyabetli çocuklarda KHD konusunda az sayıda veri vardır. Yöntem: Bu çalışmada 12 sağlıklı çocuk ve 18 diyabetli çocuğun pediyatrik kardiyoloji ünitesinde daha önceden var olan Holter monitorizasyon kayıtlarından KHD değerlendirildi. Çalışma ve kontrol grubunda 6 zaman bağımlı; (ortalama NN intervalleri, NN intervallerinin standart deviasyonu (SDNN), NN intervallerinin standart deviasyonlarının ortalaması (SDANN), SDNN indeksi, ardışık normal NN intervalleri arasındaki farkların karekökü (RMSSD), 50 milisaniyeyi aşan ardışık NN intervalleri arasındaki farkın yüzdesi (PNN50)) ve 3 frekans bağımlı; VLF (Very low frequency), LF (Low frequency) ve HF (High frequency), parametre değerlendirilerek KHD analizleri yapıldı. Bulgular: Çalışmamızda çalışma grubunda RMSSD, SDNN indeksi ve SDSD parametrelerinde kontrol grubuna göre anlamlı farklılık bulundu. Ancak frekans bağımlı analizlerde anlamlı bir fark görülmedi. Sonuç: Sonuç olarak asemptomatik diyabetik otonomik nöropatili çocuklarda KHD kardiyak otonomik nöropatiye işaret edebilir. Anahtar Kelimeler: Tip 1 diyabetes mellitus, kalp hızı değişkenliği, diyabetik otonom nöropati ABSTRACT Objective: Heart rate variability (HRV) is a noninvasive index of the neural activity of the heart. Although it is also influenced by the sympathetic activity of the heart, HRV is essentially determined by the vagal stimulation of the heart. Several HRV abnormalities have been described in adults with diabetes mellitus. However, there are few data on HRV in children with diabetes mellitus. Methods: In this study, HRV was evaluated from preexisting Holter monitoring records in pediatric cardiology unit of 12 healthy children and 18 diabetic children. All had 12 channel electrocardiography and normal standard cardiac calculating six time-domain (mean N-N interval (NN), standard deviation of the N-N intervals (SDANN), SDNN indexes, RMSSD, PNN50), and three frequency-domain (low frequency [LF], high frequency [HF] and very low frequency (VLF) indexes. In the analysis of the diabetic and control population we found statistically differences in RMSSD, SDNN and SDSD parameters. Results: In our study, significant differences were found in RMSSD, SDNN index and SDSD parameters in the study group compared to the control group. However, there was no significant difference in frequency dependent analysis. Conclusion: Our results HRV can be interpreted as evidence of cardiac autonomic neuropathy in diabetic children with asymptomatic diabetic autonomic neuropathy.
We present the successful transcatheter closure of the perforation of the cardiac wall from atria... more We present the successful transcatheter closure of the perforation of the cardiac wall from atrial appendage in a 1-year-old girl. Although open-heart surgical repair has been the primary option, percutaneous device closure should always be considered before surgery.
We report a retrograde approach for the successful closure of large left coronary artery fistulas... more We report a retrograde approach for the successful closure of large left coronary artery fistulas in the cases of two children using the Amplatzer vascular plug. This method simplified the procedure by eliminating the need for making an arteriovenous loop.
Childhood obesity is considered as one of the most common illness threating public health. Obesit... more Childhood obesity is considered as one of the most common illness threating public health. Obesity is one of the basic life threatening factor causing coronary heart diseases, hypertension, dyslipidemia, insulin resistance and metabolic syndrome. In detailed clinical studies it has been shown that this type of illness, which mostly showing clinical findings in adult age, is based in the childhood. The aim of this study was to evaluate the prevalence of metabolic syndrome in childhood obesity. Insulin resistance was found in 33 patients (50%); dyslipidemia in 49 patients (74%) and hypertension in 18 patients (27%). Metabolic syndrome was observed in 28 (42%) patients. As consequence, metabolic syndrome frequency was very high in obese children.
Myocardial infarction is extremely rare in children. However, chest pain suspected to be cardiac ... more Myocardial infarction is extremely rare in children. However, chest pain suspected to be cardiac in origin by the parents is a very common presenting symptom in pediatric emergency services. In this case, an electrocardiogram is very important in the differential diagnosis of cardiogenic complaints and should be carefully considered.
Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology, 2020
OBJECTIVE The aim of this study was to use tissue Doppler imaging to evaluate the left atrial sys... more OBJECTIVE The aim of this study was to use tissue Doppler imaging to evaluate the left atrial systolic and the left ventricular (LV) diastolic function as well as the left atrial ejection force in children who underwent transcatheter closure of a secundum atrial septal defect (ASD). METHODS Tissue Doppler measurements of the left atrial ejection force, the mitral valve, and left atrial volume were performed before the ASD closure procedure, and on the 1st day, 10th day, and 1st and 3rd months after the procedure in 56 patients and in 28 healthy controls. RESULTS There was a significant decrease in the septal and lateral a' velocities on the first day (p<0.05). There was a statistically significant increase in the septal e'/a' parameters at the third month compared with the initial measurements. The left atrial ejection force was lower in patients with an ASD than in the healthy group (10.69±4.94 kdyn, 12.31±4.05 kdyn, respectively), but there was no significant difference (p=0.053). The left atrial ejection force was significantly greater in the patient group 3 months after the procedure, and there was no significant difference compared with the control group. CONCLUSION Improvement in the LV diastolic and left atrial systolic functions was observed in children who underwent transcatheter closure of an ASD. There was no negative effect related to the devices used.
Oxidative stress may contribute to the pathogenesis of congenital heart defects, but the role of ... more Oxidative stress may contribute to the pathogenesis of congenital heart defects, but the role of dynamic thiol/disulphide homeostasis has not been evaluated. The objective of this study was to assess whether there are changes in thiol/disulphide homeostasis and nitric oxide levels in children with tetralogy of Fallot (TOF) and ventricular septal defect (VSD). A total of 47 children with congenital heart defects (24 TOF and 23 VSD) and 47 healthy age- and sex-matched controls were included in this study. Serum total thiol and native thiol levels were measured using a novel automatic spectrophotometric method. The amount of dynamic disulphide bonds and related ratios were calculated from these values. Serum nitric oxide levels were detected using a chemiluminescence assay. We found that the average native thiol, total thiol, and disulphide levels were decreased in patients with VSD when compared with healthy individuals (p < 0.001, p < 0.001, and p < 0.01, respectively). Whil...
Pulmonary artery aneurysm is a rare condition. Poststenotic pulmonary artery dilatation and aneur... more Pulmonary artery aneurysm is a rare condition. Poststenotic pulmonary artery dilatation and aneurysm may occur in congenital valvular pulmonary stenosis. We present an 11-year old girl referred to our clinic due to cardiac murmur detected by a physician during evaluation for back pain. We have noted mild congenital pulmonary stenosis and aneurysmatic dilatation of the main pulmonary artery (pulmonary artery diameter 5.6 cm) and performed pulmonary balloon valvuloplasty. Poststenotic aneurysmal dilatation secondary to congenital valvular pulmonary stenosis is a rare clinical entity. Balloon valvuloplasty is a safe and effective treatment method if there is no pulmonary hypertension or congenital heart disease with left-to-right shunt.
Isolated strains were identified as L. paracasei subsp. paracasei (41 strains), L. fermentum (24 ... more Isolated strains were identified as L. paracasei subsp. paracasei (41 strains), L. fermentum (24 strains), L. rhamnosus (11 strains), L.casei (17 strains), Lactobacillus spp. (11 strains) based on 16S rDNA sequence analysis. Almost all strains of L.casei/L.paracasei subsp. paracasei, L.rhamnosus and several strains of L. fermentum were able to produce hydrogen sulfide. Majority of isolates demonstrated an antibacterial activity against E. coli ATCC 25922, E. coli O157:H7, L. monocytogenes, S. Enteritidis, S. aureus. Our study demonstrated some important strains of Lactic acid bacteria isolated from baby faeces.
Turk Pediatri Arsivi-turkish Archives of Pediatrics, Oct 10, 2018
Cutis laxa tip1b is a rare autosomal recessive disorder caused by FBLN 4 mutation and primarily c... more Cutis laxa tip1b is a rare autosomal recessive disorder caused by FBLN 4 mutation and primarily characterized by vascular anomalies. Herein, we present five patients who are the members of the same family. The primary cardiac findings of these patients were giant aortic aneurysms. One 2.5-year-old patient with a massive aneurysm of the ascending aorta died as a result of compression to the heart chambers, trachea, and bronchi. The bentall procedure was performed in three of our patients who are under follow-up. One patient is still under clinical follow-up without surgery. After the diagnosis of the first patient, a genetic study was performed in which FBLN 4 mutations were investigated. Four new patients were detected during genetic screening of the family. Other 29 family members were screened bur were negative in physical examinations and echocardiography. Pedigree is important for early diagnosis of genetic diseases in asymptomatic individuals.
Objective: Transvenous permanent cardiac pacing (TPCP) has become a frequently used therapeutic m... more Objective: Transvenous permanent cardiac pacing (TPCP) has become a frequently used therapeutic modality in children. The purpose of this study was to evaluate the outcome of pediatric TPCP regarding problems and complications. Methods: Records of 155 patients (mean age 9.2+/-4.7 years) who underwent implantation of TPCP between 1993 and 2003 were reviewed retrospectively. Indications for pacing included atrioventricular block in 76% and sinus node dysfunction in 22% patients. In 92 patients, bradyarrhythmia was secondary to cardiac surgery. Percutaneous subclavian puncture was used for lead implantation in 96% of patients. Pacemakers were placed to the right side of the chest in 84% and in the subpectoral area in 68%. Pacing modes were VVIR in 72%, VDD in 13%, AAIR in 8%, and DDD in 7% of patients at the initial implantation time. Of all electrodes, 95% had steroid elution and 53% had an active fixation mechanism. Mean follow-up period was 37+/-28 (1-120) months. Results: Forty-five (29%) patients had 21 minor and 45 major complications. Forty-four of 76 revisions were due to lead problems and battery extraction. Most of the lead problems were dislodgment and stretching (n=14). Kaplan Meier analysis of lead survival did not show any difference between lead types. During the follow-up, there were three sudden unexpected deaths. Conclusions: In children, TPCP can be used safely and effectively. Although, complications are possible and sometimes lead or generator revision may be necessary, long-term outcome is favorable.
Bilateral ductal stenting should be performed in cases of discontinuity of the pulmonary branches... more Bilateral ductal stenting should be performed in cases of discontinuity of the pulmonary branches and pulmonary atresia. Performing this procedure via the carotid artery in small infants can be very difficult and challenging. We present a case of bilateral ductal stenting via both the femoral and carotid arteries in a little child with tetralogy of Fallot with pulmonary atresia and a nonconfluent pulmonary artery and bilateral ductus arteriosus.
World Journal for Pediatric and Congenital Heart Surgery, Feb 6, 2016
One of the most rare and dangerous complications of a modified Blalock-Taussig shunt involves the... more One of the most rare and dangerous complications of a modified Blalock-Taussig shunt involves the formation of a pseudoaneurysm. A pseudoaneurysm may rupture or may result in other adverse events including compression of mediastinal structures or collapse of the underlying lung parenchyma. Shunt-related pseudoaneurysm may be associated with shunt occlusion, bacteremia, or pulmonary hemorrhage. We describe two cases complicated by large pseudoaneurysm formation, following systemic-to-pulmonary artery shunt operations. The patients in question had recurrent pulmonary hemorrhage. Both underwent successful placement of covered coronary artery stents.
Objective: Conotruncal heart defects represent 10%-15% of congenital heart diseases and mostly in... more Objective: Conotruncal heart defects represent 10%-15% of congenital heart diseases and mostly include tetralogy of Fallot, pulmonary atresia with ventricular septal defect, truncus arteriosus, and interrupted aortic arch. Methods: This study aimed to investigate the prevalence of 22q11.2 deletion (Del22) with fluorescent in situ hybridization analysis among children followed with conotruncal heart defects. In 104 cases with conotruncal heart defects, the 22q11.2 region was screened for deletion through the fluorescent in situ hybridization analysis using a probe specific to this region. Results: The fluorescent in situ hybridization analysis performed in patients with conotruncal heart defects showed that Del22 was present in 3 cases in Group I (70 pts) with isolated cardiopathy (4.3%), 2 cases in Group II (29 pts) with cardiopathy + dysmorphism (6.9%), 2 cases in Group III (2 pts) with cardiopathy + immunodeficiency + dysmorphism (100%), and 1 case in Group IV (3 pts) with cardiopathy + immunodeficiency (33.3%) (P < .05). Eight (7.5%) of 104 patients with conotruncal heart defects were found to have Del22. Conclusions: The results obtained from the present study are compatible with the literature. The clinical manifestation of Del22 is extremely variable. With additional abnormalities such as immunodeficiency and dysmorphic features, Del22 positivity was increasing statistically.
The internal jugular vein is not a typical vascular access line during the percutaneous closure o... more The internal jugular vein is not a typical vascular access line during the percutaneous closure of an atrial septal defect. We report the closure of a double atrial septal defect with a single device, using a transjugular venous approach, in a child with an inferior vena cava obstructed by a thrombosis due to previous cardiac catheterization. That the transjugular venous approach can be used as a possible alternative during the transcatheter closure of an atrial septal defect in children, when the inferior vena cava access is not possible.
Kalp hızı değişkenliği (KHD) kalbin nöral aktivitesini değerlendiren non invaziv bir indekstir. D... more Kalp hızı değişkenliği (KHD) kalbin nöral aktivitesini değerlendiren non invaziv bir indekstir. Diyabetli yetişkinlerde çeşitli kalp hızı değişkenliği anormallikleri tespit edilmiştir. Bununla birlikte diyabetli çocuklarda KHD konusunda az sayıda veri vardır. Yöntem: Bu çalışmada 12 sağlıklı çocuk ve 18 diyabetli çocuğun pediyatrik kardiyoloji ünitesinde daha önceden var olan Holter monitorizasyon kayıtlarından KHD değerlendirildi. Çalışma ve kontrol grubunda 6 zaman bağımlı; (ortalama NN intervalleri, NN intervallerinin standart deviasyonu (SDNN), NN intervallerinin standart deviasyonlarının ortalaması (SDANN), SDNN indeksi, ardışık normal NN intervalleri arasındaki farkların karekökü (RMSSD), 50 milisaniyeyi aşan ardışık NN intervalleri arasındaki farkın yüzdesi (PNN50)) ve 3 frekans bağımlı; VLF (Very low frequency), LF (Low frequency) ve HF (High frequency), parametre değerlendirilerek KHD analizleri yapıldı. Bulgular: Çalışmamızda çalışma grubunda RMSSD, SDNN indeksi ve SDSD parametrelerinde kontrol grubuna göre anlamlı farklılık bulundu. Ancak frekans bağımlı analizlerde anlamlı bir fark görülmedi. Sonuç: Sonuç olarak asemptomatik diyabetik otonomik nöropatili çocuklarda KHD kardiyak otonomik nöropatiye işaret edebilir. Anahtar Kelimeler: Tip 1 diyabetes mellitus, kalp hızı değişkenliği, diyabetik otonom nöropati ABSTRACT Objective: Heart rate variability (HRV) is a noninvasive index of the neural activity of the heart. Although it is also influenced by the sympathetic activity of the heart, HRV is essentially determined by the vagal stimulation of the heart. Several HRV abnormalities have been described in adults with diabetes mellitus. However, there are few data on HRV in children with diabetes mellitus. Methods: In this study, HRV was evaluated from preexisting Holter monitoring records in pediatric cardiology unit of 12 healthy children and 18 diabetic children. All had 12 channel electrocardiography and normal standard cardiac calculating six time-domain (mean N-N interval (NN), standard deviation of the N-N intervals (SDANN), SDNN indexes, RMSSD, PNN50), and three frequency-domain (low frequency [LF], high frequency [HF] and very low frequency (VLF) indexes. In the analysis of the diabetic and control population we found statistically differences in RMSSD, SDNN and SDSD parameters. Results: In our study, significant differences were found in RMSSD, SDNN index and SDSD parameters in the study group compared to the control group. However, there was no significant difference in frequency dependent analysis. Conclusion: Our results HRV can be interpreted as evidence of cardiac autonomic neuropathy in diabetic children with asymptomatic diabetic autonomic neuropathy.
We present the successful transcatheter closure of the perforation of the cardiac wall from atria... more We present the successful transcatheter closure of the perforation of the cardiac wall from atrial appendage in a 1-year-old girl. Although open-heart surgical repair has been the primary option, percutaneous device closure should always be considered before surgery.
We report a retrograde approach for the successful closure of large left coronary artery fistulas... more We report a retrograde approach for the successful closure of large left coronary artery fistulas in the cases of two children using the Amplatzer vascular plug. This method simplified the procedure by eliminating the need for making an arteriovenous loop.
Childhood obesity is considered as one of the most common illness threating public health. Obesit... more Childhood obesity is considered as one of the most common illness threating public health. Obesity is one of the basic life threatening factor causing coronary heart diseases, hypertension, dyslipidemia, insulin resistance and metabolic syndrome. In detailed clinical studies it has been shown that this type of illness, which mostly showing clinical findings in adult age, is based in the childhood. The aim of this study was to evaluate the prevalence of metabolic syndrome in childhood obesity. Insulin resistance was found in 33 patients (50%); dyslipidemia in 49 patients (74%) and hypertension in 18 patients (27%). Metabolic syndrome was observed in 28 (42%) patients. As consequence, metabolic syndrome frequency was very high in obese children.
Myocardial infarction is extremely rare in children. However, chest pain suspected to be cardiac ... more Myocardial infarction is extremely rare in children. However, chest pain suspected to be cardiac in origin by the parents is a very common presenting symptom in pediatric emergency services. In this case, an electrocardiogram is very important in the differential diagnosis of cardiogenic complaints and should be carefully considered.
Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology, 2020
OBJECTIVE The aim of this study was to use tissue Doppler imaging to evaluate the left atrial sys... more OBJECTIVE The aim of this study was to use tissue Doppler imaging to evaluate the left atrial systolic and the left ventricular (LV) diastolic function as well as the left atrial ejection force in children who underwent transcatheter closure of a secundum atrial septal defect (ASD). METHODS Tissue Doppler measurements of the left atrial ejection force, the mitral valve, and left atrial volume were performed before the ASD closure procedure, and on the 1st day, 10th day, and 1st and 3rd months after the procedure in 56 patients and in 28 healthy controls. RESULTS There was a significant decrease in the septal and lateral a' velocities on the first day (p<0.05). There was a statistically significant increase in the septal e'/a' parameters at the third month compared with the initial measurements. The left atrial ejection force was lower in patients with an ASD than in the healthy group (10.69±4.94 kdyn, 12.31±4.05 kdyn, respectively), but there was no significant difference (p=0.053). The left atrial ejection force was significantly greater in the patient group 3 months after the procedure, and there was no significant difference compared with the control group. CONCLUSION Improvement in the LV diastolic and left atrial systolic functions was observed in children who underwent transcatheter closure of an ASD. There was no negative effect related to the devices used.
Oxidative stress may contribute to the pathogenesis of congenital heart defects, but the role of ... more Oxidative stress may contribute to the pathogenesis of congenital heart defects, but the role of dynamic thiol/disulphide homeostasis has not been evaluated. The objective of this study was to assess whether there are changes in thiol/disulphide homeostasis and nitric oxide levels in children with tetralogy of Fallot (TOF) and ventricular septal defect (VSD). A total of 47 children with congenital heart defects (24 TOF and 23 VSD) and 47 healthy age- and sex-matched controls were included in this study. Serum total thiol and native thiol levels were measured using a novel automatic spectrophotometric method. The amount of dynamic disulphide bonds and related ratios were calculated from these values. Serum nitric oxide levels were detected using a chemiluminescence assay. We found that the average native thiol, total thiol, and disulphide levels were decreased in patients with VSD when compared with healthy individuals (p < 0.001, p < 0.001, and p < 0.01, respectively). Whil...
Pulmonary artery aneurysm is a rare condition. Poststenotic pulmonary artery dilatation and aneur... more Pulmonary artery aneurysm is a rare condition. Poststenotic pulmonary artery dilatation and aneurysm may occur in congenital valvular pulmonary stenosis. We present an 11-year old girl referred to our clinic due to cardiac murmur detected by a physician during evaluation for back pain. We have noted mild congenital pulmonary stenosis and aneurysmatic dilatation of the main pulmonary artery (pulmonary artery diameter 5.6 cm) and performed pulmonary balloon valvuloplasty. Poststenotic aneurysmal dilatation secondary to congenital valvular pulmonary stenosis is a rare clinical entity. Balloon valvuloplasty is a safe and effective treatment method if there is no pulmonary hypertension or congenital heart disease with left-to-right shunt.
Isolated strains were identified as L. paracasei subsp. paracasei (41 strains), L. fermentum (24 ... more Isolated strains were identified as L. paracasei subsp. paracasei (41 strains), L. fermentum (24 strains), L. rhamnosus (11 strains), L.casei (17 strains), Lactobacillus spp. (11 strains) based on 16S rDNA sequence analysis. Almost all strains of L.casei/L.paracasei subsp. paracasei, L.rhamnosus and several strains of L. fermentum were able to produce hydrogen sulfide. Majority of isolates demonstrated an antibacterial activity against E. coli ATCC 25922, E. coli O157:H7, L. monocytogenes, S. Enteritidis, S. aureus. Our study demonstrated some important strains of Lactic acid bacteria isolated from baby faeces.
Uploads
Papers by Osman Başpınar