Following publication of the original article [1], the authors identified that the collaborating ... more Following publication of the original article [1], the authors identified that the collaborating authors part of the collaborating author group CCCC Consortium was missing. The collaborating author group is available and included as Additional file 1 in this article.
Background The role of neuromuscular blocking agents (NMBAs) in coronavirus disease 2019 (COVID-1... more Background The role of neuromuscular blocking agents (NMBAs) in coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) is not fully elucidated. Therefore, we aimed to investigate in COVID-19 patients with moderate-to-severe ARDS the impact of early use of NMBAs on 90-day mortality, through propensity score (PS) matching analysis. Methods We analyzed a convenience sample of patients with COVID-19 and moderate-to-severe ARDS, admitted to 244 intensive care units within the COVID-19 Critical Care Consortium, from February 1, 2020, through October 31, 2021. Patients undergoing at least 2 days and up to 3 consecutive days of NMBAs (NMBA treatment), within 48 h from commencement of IMV were compared with subjects who did not receive NMBAs or only upon commencement of IMV (control). The primary objective in the PS-matched cohort was comparison between groups in 90-day in-hospital mortality, assessed through Cox proportional hazard modeling. Secondary objectives were...
Indonesian Journal of Anesthesiology and Reanimation
Introduction: Heart disease is one of the most common causes of maternal death. The incidence has... more Introduction: Heart disease is one of the most common causes of maternal death. The incidence has increased since women with congenital and acquired heart disease reached fertile age. The circulation system changes during pregnancy which are induced by changes in the progesterone. The changes in progesterone levels increase heart work and cause death in pregnant women. Objective: This report aims to elaborate on the administration of nitrates as the management of labor in rheumatic heart disease (RHD). Case Report: A 27-year-old woman complained of shortness of breath and wanted to give birth. The patient was 38 weeks pregnant and had a history of heart disease. Antero-posterior chest radiography examination showed pulmonary edema and cardiomegaly. The patient was examined using echocardiography before spontaneous labor and was diagnosed as pregnant with rheumatic heart disease. As an emergency management, the patient was given painless spontaneous labor. The patient was given nitra...
Supplemental material, sj-jpg-1-aan-10.1177_0218492321998523 for Methylene blue for vasoplegic sy... more Supplemental material, sj-jpg-1-aan-10.1177_0218492321998523 for Methylene blue for vasoplegic syndrome in cardiopulmonary bypass surgery: A systematic review and meta-analysis by Fajar Perdhana, Nabila A Kloping, Andro P Witarto, David Nugraha, Niwanda Yogiswara, Kevin Luke, Yudhistira P Kloping and Nancy M Rehatta in Asian Cardiovascular & Thoracic Annals
Indonesian Journal of Tropical and Infectious Disease, 2017
Ventilator-associated pneumonia (VAP) remains a problem with the highest cos, morbidity and morta... more Ventilator-associated pneumonia (VAP) remains a problem with the highest cos, morbidity and mortalityt in the Intensive Care Unit (ICU). The correlation between mechanical ventilation and pneumonia is considered as common sense, yet scientific evidence to support this statement is still needed. This research aims to analyze the bacterial colony grows in mechanical ventilation circuit and those grew in the patient’s sputum culture. We performed an observational study. Samples for bacterial culture were taken from ventilator circuit and patient sputum on Day-0, Day-3 and Day-7. Sputum samplings are collected using double catheter tracheal aspiration technique; Results are then analyzed with Chi-square test. While the similarity of bacteria species in ventilator circuit to patient’s sputum is analyzed with Binomial test. Two samples are dropped out immediately due to the rate of bacterial growth on Day-0. Bacterial colony growth in ventilator circuit shows a significant difference on D...
Background To evaluate the benefit of methylene blue as an adjunct treatment by assessing hemodyn... more Background To evaluate the benefit of methylene blue as an adjunct treatment by assessing hemodynamic, morbidity rate, intensive care unit length of stay, and mortality rate outcomes in adult patients with vasoplegic syndrome. Methods A systematic search through electronic databases including Pubmed, Embase, Scopus, and Medline for studies assessing the use of methylene blue in patients with vasoplegic syndrome compared to control treatments. The Newcastle–Ottawa Scale tool was used for observational studies, and Jadad Scale was used for controlled trials to assess the risk of bias. Results This systematic review included six studies for qualitative synthesis and five studies for quantitative synthesis. Pooled analysis revealed that mean arterial pressure, systemic vascular resistance, heart rate, and hospital stay were not statistically significant in methylene blue administration compared to control. However, administration of methylene blue in vasoplegic syndrome patients signifi...
Introduction: The incidence of postoperative CABG AKI in Indonesia, one of which is in the city o... more Introduction: The incidence of postoperative CABG AKI in Indonesia, one of which is in the city of Surabaya, is known to reach 69.8%. For this reason, this study was prepared with the aim of analyzing the risk factors of Acute Kidney Injury Incidence following coronary artery bypass graft with cardiopulmonary bypass. Method: The study conducted a prospective analytic study on CABG patients with the CPB technique without a history of previous kidney disease at a hospital in Indonesia in the period 2020. Results: Through the results of the study, it was found that 14 people were diagnosed as AKI after surgery, of which 11 were men. On the other hand, it is also known that AKI patients also experience a longer duration of CPB and also lower plasma osmolarity Conclusion: Of all the factors it is known that eGFR is an independent risk factor for AKI.
Tetrallogy of Fallot (TOF) didefinisikan sebagai kondisi penyakit jantung kongenital yang ditanda... more Tetrallogy of Fallot (TOF) didefinisikan sebagai kondisi penyakit jantung kongenital yang ditandai dengan adanya obstruksi right ventricle outflow tract (RVOTO) baik stenosis pada supravalvar, valvar dan subvalvar, adanya ventricle septal defect (VSD), dextroposisi dari aorta dan hipertrofi ventrikel kanan. Kondisi ini diperberat dengan kardiomiopati dilatatif yang menyebabkan pasien jatuh pada keadaan gagal jantung dan pembentukan trombus multipel di semua ruang jantung. Tantangan perioperatif adalah terjadinya tet spell pada periode pre CardioPulmonary By pass (CPB), dan depresi kontraktilitas dapat menyebabkan gagal jantung. Pasca operasi beresiko tinggi untuk terjadi low cardiac output syndrome. Anak usia 2 tahun 10 bulan dengan diagnosis TOF dan kardiomiopati dilatatif disertai pembentukan trombus multipel yang menjalani prosedur total koreksi, dengan penyulit penyerta gagal jantung yang membaik dengan terapi medikamentosa, fungsi ventrikel kiri dan ventrikel kanan yang turun. ...
Predictions regarding damaged land access by a serial earthquake in Lombok, West Nusa Tenggara in... more Predictions regarding damaged land access by a serial earthquake in Lombok, West Nusa Tenggara in 2018, was the background of the Rumah Sakit Terapung Ksatria Airlangga (RSTKA), being sent. RSTKA is phinisi ship with an operating theatre and other healthcare facilities. The earthquake was not accompanied by a tsunami, so the dock was suitable to be used for leaning. The study analyzes patient data in RSTKA, and as an evaluation of field hospitals. This study used observational descriptive design. Obtained 1601 patients with disease distribution classified as trauma and non-trauma. A number of patients who came to RSTKA were volatile. The number of cases recorded was more than the number of patients because some patients had more than one health problem. Trauma cases recorded 121 cases (6.7%) while non-trauma 1679 cases (93.3%). Non-trauma cases have increased rapidly since the fourth day. The trauma case was dominated by soft tissue injury 57.02%. Non-trauma cases were dominated by ...
Right ventricular dysfunction and failure receive much less attention than the left ventricular f... more Right ventricular dysfunction and failure receive much less attention than the left ventricular failure. Right ventricular dysfunction or failure is associated with increased mortality rates in cardiac surgery, surgical cases other than cardiac surgery and also in patients treated in the ICU. The purpose of this article review was to describe the anatomy, physiology and pathophysiology of right ventricular failure, its detection and diagnosis, and management considerations from anesthetic point of view, including preoperative, intraoperative and postoperative stages. Cardiac surgery may result in right ventricular failure. For example, 0.1% post cardiotomy patients experience severe right heart failure and require long-term inotropic support, and so do 2-3% of post-transplant patients, and 20-30% of patients installed with instrument in his left heart. Therefore, anesthesiologists play a major role in perioperative and postoperative intensive care and are obliged to comprehend the n...
Following publication of the original article [1], the authors identified that the collaborating ... more Following publication of the original article [1], the authors identified that the collaborating authors part of the collaborating author group CCCC Consortium was missing. The collaborating author group is available and included as Additional file 1 in this article.
Background The role of neuromuscular blocking agents (NMBAs) in coronavirus disease 2019 (COVID-1... more Background The role of neuromuscular blocking agents (NMBAs) in coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) is not fully elucidated. Therefore, we aimed to investigate in COVID-19 patients with moderate-to-severe ARDS the impact of early use of NMBAs on 90-day mortality, through propensity score (PS) matching analysis. Methods We analyzed a convenience sample of patients with COVID-19 and moderate-to-severe ARDS, admitted to 244 intensive care units within the COVID-19 Critical Care Consortium, from February 1, 2020, through October 31, 2021. Patients undergoing at least 2 days and up to 3 consecutive days of NMBAs (NMBA treatment), within 48 h from commencement of IMV were compared with subjects who did not receive NMBAs or only upon commencement of IMV (control). The primary objective in the PS-matched cohort was comparison between groups in 90-day in-hospital mortality, assessed through Cox proportional hazard modeling. Secondary objectives were...
Indonesian Journal of Anesthesiology and Reanimation
Introduction: Heart disease is one of the most common causes of maternal death. The incidence has... more Introduction: Heart disease is one of the most common causes of maternal death. The incidence has increased since women with congenital and acquired heart disease reached fertile age. The circulation system changes during pregnancy which are induced by changes in the progesterone. The changes in progesterone levels increase heart work and cause death in pregnant women. Objective: This report aims to elaborate on the administration of nitrates as the management of labor in rheumatic heart disease (RHD). Case Report: A 27-year-old woman complained of shortness of breath and wanted to give birth. The patient was 38 weeks pregnant and had a history of heart disease. Antero-posterior chest radiography examination showed pulmonary edema and cardiomegaly. The patient was examined using echocardiography before spontaneous labor and was diagnosed as pregnant with rheumatic heart disease. As an emergency management, the patient was given painless spontaneous labor. The patient was given nitra...
Supplemental material, sj-jpg-1-aan-10.1177_0218492321998523 for Methylene blue for vasoplegic sy... more Supplemental material, sj-jpg-1-aan-10.1177_0218492321998523 for Methylene blue for vasoplegic syndrome in cardiopulmonary bypass surgery: A systematic review and meta-analysis by Fajar Perdhana, Nabila A Kloping, Andro P Witarto, David Nugraha, Niwanda Yogiswara, Kevin Luke, Yudhistira P Kloping and Nancy M Rehatta in Asian Cardiovascular & Thoracic Annals
Indonesian Journal of Tropical and Infectious Disease, 2017
Ventilator-associated pneumonia (VAP) remains a problem with the highest cos, morbidity and morta... more Ventilator-associated pneumonia (VAP) remains a problem with the highest cos, morbidity and mortalityt in the Intensive Care Unit (ICU). The correlation between mechanical ventilation and pneumonia is considered as common sense, yet scientific evidence to support this statement is still needed. This research aims to analyze the bacterial colony grows in mechanical ventilation circuit and those grew in the patient’s sputum culture. We performed an observational study. Samples for bacterial culture were taken from ventilator circuit and patient sputum on Day-0, Day-3 and Day-7. Sputum samplings are collected using double catheter tracheal aspiration technique; Results are then analyzed with Chi-square test. While the similarity of bacteria species in ventilator circuit to patient’s sputum is analyzed with Binomial test. Two samples are dropped out immediately due to the rate of bacterial growth on Day-0. Bacterial colony growth in ventilator circuit shows a significant difference on D...
Background To evaluate the benefit of methylene blue as an adjunct treatment by assessing hemodyn... more Background To evaluate the benefit of methylene blue as an adjunct treatment by assessing hemodynamic, morbidity rate, intensive care unit length of stay, and mortality rate outcomes in adult patients with vasoplegic syndrome. Methods A systematic search through electronic databases including Pubmed, Embase, Scopus, and Medline for studies assessing the use of methylene blue in patients with vasoplegic syndrome compared to control treatments. The Newcastle–Ottawa Scale tool was used for observational studies, and Jadad Scale was used for controlled trials to assess the risk of bias. Results This systematic review included six studies for qualitative synthesis and five studies for quantitative synthesis. Pooled analysis revealed that mean arterial pressure, systemic vascular resistance, heart rate, and hospital stay were not statistically significant in methylene blue administration compared to control. However, administration of methylene blue in vasoplegic syndrome patients signifi...
Introduction: The incidence of postoperative CABG AKI in Indonesia, one of which is in the city o... more Introduction: The incidence of postoperative CABG AKI in Indonesia, one of which is in the city of Surabaya, is known to reach 69.8%. For this reason, this study was prepared with the aim of analyzing the risk factors of Acute Kidney Injury Incidence following coronary artery bypass graft with cardiopulmonary bypass. Method: The study conducted a prospective analytic study on CABG patients with the CPB technique without a history of previous kidney disease at a hospital in Indonesia in the period 2020. Results: Through the results of the study, it was found that 14 people were diagnosed as AKI after surgery, of which 11 were men. On the other hand, it is also known that AKI patients also experience a longer duration of CPB and also lower plasma osmolarity Conclusion: Of all the factors it is known that eGFR is an independent risk factor for AKI.
Tetrallogy of Fallot (TOF) didefinisikan sebagai kondisi penyakit jantung kongenital yang ditanda... more Tetrallogy of Fallot (TOF) didefinisikan sebagai kondisi penyakit jantung kongenital yang ditandai dengan adanya obstruksi right ventricle outflow tract (RVOTO) baik stenosis pada supravalvar, valvar dan subvalvar, adanya ventricle septal defect (VSD), dextroposisi dari aorta dan hipertrofi ventrikel kanan. Kondisi ini diperberat dengan kardiomiopati dilatatif yang menyebabkan pasien jatuh pada keadaan gagal jantung dan pembentukan trombus multipel di semua ruang jantung. Tantangan perioperatif adalah terjadinya tet spell pada periode pre CardioPulmonary By pass (CPB), dan depresi kontraktilitas dapat menyebabkan gagal jantung. Pasca operasi beresiko tinggi untuk terjadi low cardiac output syndrome. Anak usia 2 tahun 10 bulan dengan diagnosis TOF dan kardiomiopati dilatatif disertai pembentukan trombus multipel yang menjalani prosedur total koreksi, dengan penyulit penyerta gagal jantung yang membaik dengan terapi medikamentosa, fungsi ventrikel kiri dan ventrikel kanan yang turun. ...
Predictions regarding damaged land access by a serial earthquake in Lombok, West Nusa Tenggara in... more Predictions regarding damaged land access by a serial earthquake in Lombok, West Nusa Tenggara in 2018, was the background of the Rumah Sakit Terapung Ksatria Airlangga (RSTKA), being sent. RSTKA is phinisi ship with an operating theatre and other healthcare facilities. The earthquake was not accompanied by a tsunami, so the dock was suitable to be used for leaning. The study analyzes patient data in RSTKA, and as an evaluation of field hospitals. This study used observational descriptive design. Obtained 1601 patients with disease distribution classified as trauma and non-trauma. A number of patients who came to RSTKA were volatile. The number of cases recorded was more than the number of patients because some patients had more than one health problem. Trauma cases recorded 121 cases (6.7%) while non-trauma 1679 cases (93.3%). Non-trauma cases have increased rapidly since the fourth day. The trauma case was dominated by soft tissue injury 57.02%. Non-trauma cases were dominated by ...
Right ventricular dysfunction and failure receive much less attention than the left ventricular f... more Right ventricular dysfunction and failure receive much less attention than the left ventricular failure. Right ventricular dysfunction or failure is associated with increased mortality rates in cardiac surgery, surgical cases other than cardiac surgery and also in patients treated in the ICU. The purpose of this article review was to describe the anatomy, physiology and pathophysiology of right ventricular failure, its detection and diagnosis, and management considerations from anesthetic point of view, including preoperative, intraoperative and postoperative stages. Cardiac surgery may result in right ventricular failure. For example, 0.1% post cardiotomy patients experience severe right heart failure and require long-term inotropic support, and so do 2-3% of post-transplant patients, and 20-30% of patients installed with instrument in his left heart. Therefore, anesthesiologists play a major role in perioperative and postoperative intensive care and are obliged to comprehend the n...
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