TRPM7

TRPM7
Identifiers
Aliases	TRPM7, ALSPDC, CHAK, CHAK1, LTRPC7, LTrpC-7, TRP-PLIK, transient receptor potential cation channel subfamily M member 7
External IDs	OMIM: 605692; MGI: 1929996; HomoloGene: 9774; GeneCards: TRPM7; OMA:TRPM7 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	50,686,797 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	126,718,150 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; Achilles tendon; ; cardiac muscle tissue of right atrium; ; epithelium of colon; ; sural nerve; ; cartilage tissue; ; testicle; ; gastric mucosa; ; right lobe of liver; ; buccal mucosa cell;
	Top expressed in
	molar; ; Rostral migratory stream; ; tail of embryo; ; Gonadal ridge; ; parotid gland; ; saccule; ; epithelium of small intestine; ; pineal gland; ; atrium; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; myosin binding; metal ion binding; kinase activity; protein serine/threonine kinase activity; ion channel activity; actin binding; ATP binding; calcium channel activity;
Cellular component	integral component of membrane; membrane; ruffle; plasma membrane;
Biological process	cellular magnesium ion homeostasis; calcium-dependent cell-matrix adhesion; programmed cell death; phosphorylation; actomyosin structure organization; cation transport; ion transport; protein tetramerization; protein phosphorylation; calcium ion transmembrane transport; protein autophosphorylation; necroptosis; calcium ion transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	54822
	58800
	ENSG00000092439
	ENSMUSG00000027365
	Q96QT4
	Q923J1
	NM_001301212; NM_017672
	NM_001164325; NM_021450
	NP_001288141; NP_060142
	NP_001157797; NP_067425
	Wikidata
View/Edit Human	View/Edit Mouse

Transient receptor potential cation channel, subfamily M, member 7, also known as TRPM7, is a human gene encoding a protein of the same name.

Function

TRPs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRPM7 is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.^[5]

Interactions

TRPM7 has been shown to interact with PLCB1^[6] and PLCB2.^[6]

Clinical relevance

Patients with pathogenic variants in the TRPM7 gene suffer from hypomagnesemia, seizures and developmental delay.^[7]^[8]

Defects in this gene have been associated with magnesium deficiency in human microvascular endothelial cells.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000092439 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027365 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: TRPM7 transient receptor potential cation channel, subfamily M, member 7".
^ ^a ^b Runnels LW, Yue L, Clapham DE (May 2002). "The TRPM7 channel is inactivated by PIP(2) hydrolysis". Nat. Cell Biol. 4 (5): 329–36. doi:10.1038/ncb781. PMID 11941371. S2CID 21592843.
^ Vargas-Poussou R, Claverie-Martin F, Prot-Bertoye C, Carotti V, van der Wijst J, Perdomo-Ramirez A, Fraga-Rodriguez GM, Hureaux M, Bos C, Latta F, Houillier P, Hoenderop JG, de Baaij JH (2023). "Possible role for rare TRPM7 variants in patients with hypomagnesaemia with secondary hypocalcaemia". Nephrology Dialysis Transplantation. 38 (3): 679–690. doi:10.1093/ndt/gfac182. PMC 9976740. PMID 35561741.
^ Bosman W, Butler KM, Chang CA, Ganapathi M, Guzman E, Latta F, Chung WK, Claverie-Martin F, Davis JM, Hoenderop JG, de Baaij JH (2024). "Pathogenic heterozygous TRPM7 variants and hypomagnesemia with developmental delay". Clinical Kidney Journal. sfae211 (8): sfae211. doi:10.1093/ckj/sfae211. PMC 11295107. PMID 39099563.
^ Baldoli E, Maier JA (2012). "Silencing TRPM7 mimics the effects of magnesium deficiency in human microvascular endothelial cells". Angiogenesis. 15 (1): 47–57. doi:10.1007/s10456-011-9242-0. PMID 22183257. S2CID 16274084.

External links

TRPM7+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000092439 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027365 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Entrez Gene: TRPM7 transient receptor potential cation channel, subfamily M, member 7".

[pmid11941371-6] Runnels LW, Yue L, Clapham DE (May 2002). "The TRPM7 channel is inactivated by PIP(2) hydrolysis". Nat. Cell Biol. 4 (5): 329–36. doi:10.1038/ncb781. PMID 11941371. S2CID 21592843.

[doi.10.1093/ndt/gfac182-7] Vargas-Poussou R, Claverie-Martin F, Prot-Bertoye C, Carotti V, van der Wijst J, Perdomo-Ramirez A, Fraga-Rodriguez GM, Hureaux M, Bos C, Latta F, Houillier P, Hoenderop JG, de Baaij JH (2023). "Possible role for rare TRPM7 variants in patients with hypomagnesaemia with secondary hypocalcaemia". Nephrology Dialysis Transplantation. 38 (3): 679–690. doi:10.1093/ndt/gfac182. PMC 9976740. PMID 35561741.

[doi.10.1093/ckj/sfae211-8] Bosman W, Butler KM, Chang CA, Ganapathi M, Guzman E, Latta F, Chung WK, Claverie-Martin F, Davis JM, Hoenderop JG, de Baaij JH (2024). "Pathogenic heterozygous TRPM7 variants and hypomagnesemia with developmental delay". Clinical Kidney Journal. sfae211 (8): sfae211. doi:10.1093/ckj/sfae211. PMC 11295107. PMID 39099563.

[doi.10.1007/s10456-011-9242-0-9] Baldoli E, Maier JA (2012). "Silencing TRPM7 mimics the effects of magnesium deficiency in human microvascular endothelial cells". Angiogenesis. 15 (1): 47–57. doi:10.1007/s10456-011-9242-0. PMID 22183257. S2CID 16274084.

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