MMS22L

MMS22L
Identifiers
Aliases	MMS22L, C6orf167, dJ39B17.2, MMS22 like, DNA repair protein
External IDs	OMIM: 615614; MGI: 2684980; HomoloGene: 18874; GeneCards: MMS22L; OMA:MMS22L - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	97,283,217 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	24,602,950 bp
RNA expression pattern
	Top expressed in
	testicle; ; ventricular zone; ; ganglionic eminence; ; bone marrow; ; bone marrow cells; ; gonad; ; corpus callosum; ; stromal cell of endometrium; ; tonsil; ; Achilles tendon;
	Top expressed in
	ventricular zone; ; tail of embryo; ; medial ganglionic eminence; ; epiblast; ; secondary oocyte; ; zygote; ; genital tubercle; ; primary oocyte; ; endocardial cushion; ; abdominal wall;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	nuclear replication fork; MCM complex; nucleus; FACT complex; nucleoplasm; cytosol;
Biological process	double-strand break repair via homologous recombination; DNA repair; replication fork processing; cellular response to DNA damage stimulus;
	Sources:Amigo / QuickGO
Orthologs
	253714
	212377
	ENSG00000146263
	ENSMUSG00000045751
	Q6ZRQ5
	B1AUR6
	NM_198468; NM_001350599; NM_001350600
	NM_199467
	NP_940870; NP_001337528; NP_001337529
	NP_955761
	Wikidata
View/Edit Human	View/Edit Mouse

Methyl methanesulfonate-sensitivity protein 22-like also known as MMS22-like, DNA repair protein is a protein that in humans is encoded by the MMS22L gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000146263 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045751 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MMS22-like, DNA repair protein".

Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Duro E, Lundin C, Ask K, Sanchez-Pulido L, MacArtney TJ, Toth R, Ponting CP, Groth A, Helleday T, Rouse J (Nov 2010). "Identification of the MMS22L-TONSL complex that promotes homologous recombination". Molecular Cell. 40 (4): 632–44. doi:10.1016/j.molcel.2010.10.023. PMID 21055984.
O'Connell BC, Adamson B, Lydeard JR, Sowa ME, Ciccia A, Bredemeyer AL, Schlabach M, Gygi SP, Elledge SJ, Harper JW (Nov 2010). "A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability". Molecular Cell. 40 (4): 645–57. doi:10.1016/j.molcel.2010.10.022. PMC 3006237. PMID 21055985.
O'Donnell L, Panier S, Wildenhain J, Tkach JM, Al-Hakim A, Landry MC, Escribano-Diaz C, Szilard RK, Young JT, Munro M, Canny MD, Kolas NK, Zhang W, Harding SM, Ylanko J, Mendez M, Mullin M, Sun T, Habermann B, Datti A, Bristow RG, Gingras AC, Tyers MD, Brown GW, Durocher D (Nov 2010). "The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination". Molecular Cell. 40 (4): 619–31. doi:10.1016/j.molcel.2010.10.024. PMC 3031522. PMID 21055983.
Piwko W, Olma MH, Held M, Bianco JN, Pedrioli PG, Hofmann K, Pasero P, Gerlich DW, Peter M (Dec 2010). "RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells". The EMBO Journal. 29 (24): 4210–22. doi:10.1038/emboj.2010.304. PMC 3018799. PMID 21113133.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000146263 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045751 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MMS22-like, DNA repair protein".

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References

Further reading