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DAD1

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DAD1
Identifiers
AliasesDAD1, OST2, defender against cell death 1
External IDsOMIM: 600243; MGI: 101912; HomoloGene: 1027; GeneCards: DAD1; OMA:DAD1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001344

NM_001113358
NM_010015

RefSeq (protein)

NP_001335

NP_001106829
NP_034145

Location (UCSC)Chr 14: 22.56 – 22.59 MbChr 14: 54.47 – 54.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit DAD1 is an enzyme that in humans is encoded by the DAD1 gene.[5]

Function

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DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes.[5]

Interactions

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DAD1 has been shown to interact with MCL1.[6]

References

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  1. ^ Jump up to: a b c GRCh38: Ensembl release 89: ENSG00000129562Ensembl, May 2017
  2. ^ Jump up to: a b c GRCm38: Ensembl release 89: ENSMUSG00000022174Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jump up to: a b "Entrez Gene: DAD1 defender against cell death 1".
  6. ^ Makishima T, Yoshimi M, Komiyama S, Hara N, Nishimoto T (September 2000). "A subunit of the mammalian oligosaccharyltransferase, DAD1, interacts with Mcl-1, one of the bcl-2 protein family". J. Biochem. 128 (3): 399–405. doi:10.1093/oxfordjournals.jbchem.a022767. PMID 10965038.

Further reading

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