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William Rees Brebner Robertson

William Rees Brebner Robertson (31 May 1881 - 15 March 1941) was an American zoologist and early cytogeneticist who discovered the chromosomal rearrangement named in his honour, Robertsonian translocation, the most common structural chromosomal abnormalities seen in humans that result in syndromes of multiple malformations, including trisomy 13 Patau syndrome and trisomy 21 Down syndrome.[1][2][3][4][5][6][7][8][9][10][11][12]

Born in Manchester, Kansas, he was raised on a farm in Dickinson County in a small family of Scottish ancestry. Fluent in Scottish Gaelic, French and German, as a young boy he developed a keen and enduring interest in grasshoppers that proliferated in his father's fields; seven species of which formed the basis of his 1916 paper in which he described what is known as a Robertsonian translocation (ROB).[2][3][4][12]

Graduating Abilene High School he attended the University of Kansas (A.B., 1906; A.M., 1907), one of Clarence Erwin McClung's eager students of cytology. An Austin Teaching Fellow of Zoology at Harvard University (Ph.D., 1915), he obtained his doctorate in the laboratory of Edward Laurens Mark.[3]

Dr. Robertson was a research scientist of the golden era of classical genetics, a period when the tools were breeding experiments and microscopes. Returning to the University of Kansas as Professor in the Department of Zoology, then moving to the University of Missouri; during the period of 1917-27 Dr. Robertson devoted himself to the extensive breeding of 4,800 turkeys and derived a valuable set of exquisite data, including many skin and feather samples.[3] [1]

Moving to Iowa in 1930, while Dr. Robertson never published on the turkey materials and data, he left them in such order that they were subsequently published in 1943 by his doctoral students. Held in great esteem by the students he inspired with measured and painstaking research practices, he was deceased before the preparation of their manuscript, while Professor in the Anatomy Department of the Medical School of the University of Iowa. Valuable contributions to the understanding of inheritance in these birds were proven in his data.[3] [1]

The final years of his life in Iowa were devoted to teaching, graduate students and further cytogenetics research dealing with the chromosomal relations in pigmy locusts and some larger grasshoppers. He also contributed a chapter on human heredity, "The Biological and Eugenical Background of The Family" to Jung's "Modern Marriage."[3][13]

Dr. Robertson is buried alongside his parents at the Keystone Cemetery in Dickinson County, Kansas; his scientific legacy born of childhood curiosity on its plains.[1] [14]

[2] [3] [4] [5] [6] [7] [8][9] [10] [11] [12] [13] [15]

References

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  1. ^ a b c d Robertson, W. R. B.; Bohren, B. B.; Warren, D. C. (1943). "The Inheritance of Plumage in the Turkey". Journal of Heredity. 34 (8): 246–256. doi:10.1093/oxfordjournals.jhered.a105298.
  2. ^ a b c Robertson, W.R.B. (1916). "Chromosome studies. I. Taxonomic relationships shown in the chromosomes of Tettigidae and Acrididae. V-shaped chromosomes and their significance in Acrididae, Locustidae and Gryllidae: chromosome and variation". Journal of Morphology. 27 (2): 179–331. doi:10.1002/jmor.1050270202. S2CID 86497936.
  3. ^ a b c d e f g Nabors, R.K. (January 30, 1942). "Obituary: William Rees Brebner Robertson (1881-1941)". Science. 95 (2457): 113–114. doi:10.1126/science.95.2457.113. PMID 17795644.
  4. ^ a b c Hartwell, Leland (2011). Genetics From Genes to Genomes, 4e (4 ed.). New York: McGraw-Hill. pp. 443, 454. ISBN 9780073525266.
  5. ^ a b Therman, E (February 1989). "The nonrandom participation of human afrocentric chromosomes in Robertsonian translocations". Annals of Human Genetics. 53 (53(Pt1)): 49–65. doi:10.1111/j.1469-1809.1989.tb01121.x. PMID 2658738. S2CID 1949436.
  6. ^ a b Zhao, WW (May 1, 2015). "Robertsonian Translocations: An Overview of 872 Robertsonian Translocations Identified in a Diagnostic Laboratory in China". PLOS ONE. 10 (5): e0122647. Bibcode:2015PLoSO..1022647Z. doi:10.1371/journal.pone.0122647. PMC 4416705. PMID 25932913.
  7. ^ a b Dolskiy, Alexander A.; Lemskaya, Natalya A.; Maksimova, Yulia V.; Shorina, Asia R.; Kolesnikova, Irina S.; Yudkin, Dmitry V. (2018). "Robertsonian translocation 13/14 associated with rRNA genes overexpression and intellectual disability". Egyptian Journal of Medical Human Genetics. 19 (2): 141–145. doi:10.1016/j.ejmhg.2017.11.002.
  8. ^ a b Engels, Hartmut; Eggermann, Thomas; Caliebe, Almut; Jelska, Anna; Schubert, Regine; Schüler, Herdit M.; Panasiuk, Barbara; Zaremba, Jacek; Latos-BieleńSka, Anna; Jakubowski, Lucjusz; Zerres, Klaus P.; Schwanitz, Gesa; Midro, Alina T. (2008). "Genetic counseling in Robertsonian translocations der(13;14): Frequencies of reproductive outcomes and infertility in 101 pedigrees**". American Journal of Medical Genetics Part A. 146A (20): 2611–2616. doi:10.1002/ajmg.a.32500. PMID 18798317. S2CID 42829871.
  9. ^ a b RACHISAN AL; NICULAE AS; TINTEA I; POP B; MILITARU M; BIZO A; HRUSCA A (2017). "Association of fragile X syndrome, Robertsonian translocation (13, 22) and autism in a child". Clujul Medical. 90 (4): 445–448. doi:10.15386/cjmed-763. PMC 5683837. PMID 29151796.
  10. ^ a b Buoni, S.; Zannolli, R.; MacUcci, F.; Pucci, L.; Mogni, M.; Pierluigi, M.; Fois, A. (2006). "Familial robertsonian 13;14 translocation with mental retardation and epilepsy". Journal of Child Neurology. 21 (6): 531–3. doi:10.1177/08830738060210060701. PMID 16948942. S2CID 44812342.
  11. ^ a b Venkateshwari, A.; Srilekha, A.; Sunitha, T.; Pratibha, N.; Jyothy, A. (2010). "Robertsonian Translocation rob (14;15) (q10:q10) in a Patient with Recurrent Abortions: A Case Report". Journal of Reproduction & Infertility. 11 (3): 197–200. PMC 3719299. PMID 23926490.
  12. ^ a b c R.J.M Gardner, Grant R Sutherland, and Lisa G. Shaffer (Nov 2011). Chromosome Abnormalities and Genetic Counseling (4 ed.) (4 ed.). Oxford University Press. pp. 140–154. ISBN 978-0-19-537533-6.{{cite book}}: CS1 maint: multiple names: authors list (link)
  13. ^ a b Jung, Moses (1940). "Modern Marriage". American Journal of Sociology. 47 (2). New York: F.S. Crofts & Company: 183–230. doi:10.1086/218887.
  14. ^ Bidau, Claudio J.; Martí, Dardo A. (2010). "110 Years of Orthopteran Cytogenetics, the Chromosomal Evolutionary Viewpoint, and Michael White's Signal Contributions to the Field". Journal of Orthoptera Research. 19 (2): 165–182. doi:10.1665/034.019.0202. hdl:11336/59292. S2CID 84319868.
  15. ^ "William Rees Brebner Robertson". Find a Grave.
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