TOMM22

Mitochondrial import receptor subunit TOM22 homolog (hTom22) is a protein that in humans is encoded by the TOMM22 gene.

TOMM22
Identifiers
Aliases	TOMM22, 1C9-2, MST065, MSTP065, TOM22, translocase of outer mitochondrial membrane 22
External IDs	OMIM: 607046; MGI: 2450248; HomoloGene: 10638; GeneCards: TOMM22; OMA:TOMM22 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.1 Start 38,681,957 bp End 38,685,421 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 E1 Start 79,555,062 bp End 79,557,601 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii mucosa of transverse colon rectum ganglionic eminence internal globus pallidus monocyte muscle of thigh apex of heart prefrontal cortex granulocyte Top expressed in spermatid spermatocyte morula neural tube epiblast Mesencephalon ileum ganglionic eminence ventricular zone embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein transmembrane transporter activity protein binding Cellular component mitochondrial outer membrane translocase complex integral component of membrane mitochondrial inner membrane mitochondrial outer membrane integral component of mitochondrial outer membrane membrane mitochondrion Biological process protein transport protein targeting to mitochondrion protein import into mitochondrial matrix intracellular protein transport protein insertion into mitochondrial outer membrane macroautophagy transport positive regulation of apoptotic process protein insertion into mitochondrial membrane protein transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56993 223696 Ensembl ENSG00000100216 ENSMUSG00000022427 UniProt Q9NS69 Q9CPQ3 RefSeq (mRNA) NM_020243 NM_172609 RefSeq (protein) NP_064628 NP_766197 Location (UCSC) Chr 22: 38.68 – 38.69 Mb Chr 15: 79.56 – 79.56 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is an integral membrane protein of the outer mitochondrial membrane. The encoded protein interacts with TOMM20 and TOMM40, and with other proteins forms a complex – the translocase of the outer membrane, to import cytosolic preproteins into the mitochondrion.

See also

• TOMM20
• TOMM40
• TOMM70A

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Suzuki H, Okazawa Y, Komiya T, et al. (2001). "Characterization of rat TOM40, a central component of the preprotein translocase of the mitochondrial outer membrane". J. Biol. Chem. 275 (48): 37930–6. doi:10.1074/jbc.M006558200. PMID 10980201.
• Johnston AJ, Hoogenraad J, Dougan DA, et al. (2003). "Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane". J. Biol. Chem. 277 (44): 42197–204. doi:10.1074/jbc.M205613200. PMID 12198123.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yano M, Terada K, Mori M (2003). "AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins". J. Cell Biol. 163 (1): 45–56. doi:10.1083/jcb.200305051. PMC 2173431. PMID 14557246.
• Yano M, Terada K, Mori M (2004). "Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity". J. Biol. Chem. 279 (11): 10808–13. doi:10.1074/jbc.M311710200. PMID 14699115.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Humphries AD, Streimann IC, Stojanovski D, et al. (2005). "Dissection of the mitochondrial import and assembly pathway for human Tom40". J. Biol. Chem. 280 (12): 11535–43. doi:10.1074/jbc.M413816200. PMID 15644312.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Bellot G, Cartron PF, Er E, et al. (2007). "TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax". Cell Death Differ. 14 (4): 785–94. doi:10.1038/sj.cdd.4402055. PMID 17096026.