Spannocchi is an Italian surname. The surname also belonged to a prominent aristocratic family from Siena, Italy.

  • Tiburzo or Tiburcio Spannocchi (1541–1609), chief engineer to kings Philip II and III of Spain
  • Emil Spannocchi (1916–1992), Austrian military officer
  • Giovanni Bonaventura Spannocchi (1742–1832), Minister of Justice for Kingdom of Italy 1802–1805
  • Angelo Spannocchi (died 1614), Sienese jurist
  • Pandolfo Spannocchi (fl. 17th-century), expert in miniature writing and his grandson of the same name published a collection of poems in 1717

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