Milacemide

Milacemide
Names
	IUPAC name N2-Pentylglycinamide
	Systematic IUPAC name 2-(Pentylamino)acetamide
Identifiers
CAS Number	76990-56-2 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL75838 ;
ChemSpider	48376 ;
MeSH	milacemide
PubChem CID	53569;
UNII	0HXT24RECU ;
CompTox Dashboard (EPA)	DTXSID10227786 ;
	InChI InChI=1S/C7H16N2O/c1-2-3-4-5-9-6-7(8)10/h9H,2-6H2,1H3,(H2,8,10) Key: GJNNXIYZWIZFRH-UHFFFAOYSA-N ;
	SMILES CCCCCNCC(N)=O;
Properties
Chemical formula	C7H16N2O
Molar mass	144.218 g·mol−1
log P	0.754
Related compounds
Related compounds	Tricine
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Milacemide (INN)^[2] is an MAO-B inhibitor and glycine prodrug.^[3] It has been studied for its effects on human memory and as a potential treatment for the symptoms of Alzheimer's disease.^[4] Early clinical trials did not show positive results however,^[3] and the drug is now abandoned and it is sold as a nonprescription drug or supplement. While milacemide is not an amino-acid, it acts similarly to glycine in the brain.^[5]

References

^ "milacemide - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 8 August 2005. Identifiers and Related Records. Retrieved 9 January 2012.
^ "International Nonproprietary Names for Pharmaceutical Substances. Supplement to WHO Chronicle, 1983, Vol. 37, No. 6 (December). Recommended International Nonproprietary Names (Rec. INN): List 23" (PDF). World Health Organization. p. 6. Retrieved 8 January 2016.
^ ^a ^b Dysken, MW; Mendels, J; LeWitt, P; Reisberg, B; Pomara, N; Wood, J; Skare, S; Fakouhi, JD; Herting, RL (May 1992). "Milacemide: a placebo-controlled study in senile dementia of the Alzheimer type". Journal of the American Geriatrics Society. 40 (5): 503–6. doi:10.1111/j.1532-5415.1992.tb02019.x. PMID 1634705. S2CID 34816755.
^ Harris, Carol Turkington ; foreword by Joseph R. (2002). The encyclopedia of the brain and brain disorders (2nd ed.). New York, NY: Facts on File. ISBN 0-8160-4774-X. Archived from the original on 2014-03-03. Retrieved 2017-09-10.{{cite book}}: CS1 maint: multiple names: authors list (link)
^ Theodore I. Lidsky and Jay S. Schneider Phd, Brain Candy (2001). Brain Candy. New York, United States Of America: Simon & Schuster. ISBN 9780743218436.

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[1] "milacemide - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 8 August 2005. Identifiers and Related Records. Retrieved 9 January 2012.

[2] "International Nonproprietary Names for Pharmaceutical Substances. Supplement to WHO Chronicle, 1983, Vol. 37, No. 6 (December). Recommended International Nonproprietary Names (Rec. INN): List 23" (PDF). World Health Organization. p. 6. Retrieved 8 January 2016.

[Dysken-3] Dysken, MW; Mendels, J; LeWitt, P; Reisberg, B; Pomara, N; Wood, J; Skare, S; Fakouhi, JD; Herting, RL (May 1992). "Milacemide: a placebo-controlled study in senile dementia of the Alzheimer type". Journal of the American Geriatrics Society. 40 (5): 503–6. doi:10.1111/j.1532-5415.1992.tb02019.x. PMID 1634705. S2CID 34816755.

[4] Harris, Carol Turkington ; foreword by Joseph R. (2002). The encyclopedia of the brain and brain disorders (2nd ed.). New York, NY: Facts on File. ISBN 0-8160-4774-X. Archived from the original on 2014-03-03. Retrieved 2017-09-10.{{cite book}}: CS1 maint: multiple names: authors list (link)

[5] Theodore I. Lidsky and Jay S. Schneider Phd, Brain Candy (2001). Brain Candy. New York, United States Of America: Simon & Schuster. ISBN 9780743218436.

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Names

IUPAC name N²-Pentylglycinamide
Systematic IUPAC name 2-(Pentylamino)acetamide^[1]
Identifiers
CAS Number	76990-56-2^Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL75838^Y
ChemSpider	48376^Y
MeSH	milacemide
PubChem CID	53569
UNII	0HXT24RECU^Y
CompTox Dashboard (EPA)	DTXSID10227786
InChI InChI=1S/C7H16N2O/c1-2-3-4-5-9-6-7(8)10/h9H,2-6H2,1H3,(H2,8,10)^Y Key: GJNNXIYZWIZFRH-UHFFFAOYSA-N^Y
SMILES CCCCCNCC(N)=O
Properties
Chemical formula	C₇H₁₆N₂O
Molar mass	144.218 g·mol⁻¹
log P	0.754
Related compounds
Related compounds	Tricine
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references