In molecular biology, intercellular adhesion molecules (ICAMs) and vascular cell adhesion molecule-1 (VCAM-1) are part of the immunoglobulin superfamily. They are important in inflammation, immune responses and in intracellular signalling events.[1] The ICAM family consists of five members, designated ICAM-1 to ICAM-5. They are known to bind to leucocyte integrins CD11/CD18 such as LFA-1 and Macrophage-1 antigen, during inflammation and in immune responses. In addition, ICAMs may exist in soluble forms in human plasma, due to activation and proteolysis mechanisms at cell surfaces.
| Intercellular adhesion molecule (ICAM), N-terminal domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 structure of the two amino-terminal domains of human intercellular adhesion molecule-1, icam-1 | |||||||||
| Identifiers | |||||||||
| Symbol | ICAM_N | ||||||||
| Pfam | PF03921 | ||||||||
| Pfam clan | CL0159 | ||||||||
| InterPro | IPR013768 | ||||||||
| SCOP2 | 1zxq / SCOPe / SUPFAM | ||||||||
| Membranome | 219 | ||||||||
| |||||||||
Mammalian intercellular adhesion molecules include:
References
edit- ^ Gahmberg CG, Tolvanen M, Kotovuori P (April 1997). "Leukocyte adhesion--structure and function of human leukocyte beta2-integrins and their cellular ligands". Eur. J. Biochem. 245 (2): 215–32. doi:10.1111/j.1432-1033.1997.00215.x. PMID 9151947.
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