Howard Yuan-Hao Chang (born 1972) is a Taiwan-born American physician-scientist. He is the Virginia and D. K. Ludwig Professor of Cancer Genomics and of Genetics at Stanford University School of Medicine[1] and a Howard Hughes Medical Institute Investigator.[2] He will be the senior vice president of research and the chief scientific officer of Amgen.[3]
Howard Y. Chang | |
|---|---|
| Born | Taipei, Taiwan |
| Alma mater | Harvard University, Massachusetts Institute of Technology |
| Scientific career | |
| Institutions | Stanford University, Amgen |
| Doctoral advisor | David Baltimore |
| Other academic advisors | |
| Howard Y. Chang | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Traditional Chinese | 張元豪 | ||||||||||
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Biography
editChang was born in Taipei, Taiwan, into a family of physicians.[4] His father, Chang Chau-hsiung, was a Taiwanese physician and politician.[5] He studied biochemistry at Harvard University and completed a doctorate in biology at the Massachusetts Institute of Technology and medical degree at Harvard Medical School as part of the "Harvard-MIT physician scientist training program" working in David Baltimore's laboratory.[6] He did his dermatology residency and postdoctoral training at Stanford with Patrick O. Brown. After starting his own lab, his group discovered unexpected transcriptional activity for noncoding DNA and identified HOTAIR which further confirmed the importance of Long non-coding RNAs.[7][8]
He was awarded the 2018 NAS Award in Molecular Biology for "discoveries of long noncoding RNAs and technologies unveiling the noncoding genome."[9] In 2024 he received the King Faisal Prize in Biology[10] and also in 2024 the Albany Medical Center Prize jointly with Adrian R. Krainer and Lynne E. Maquat.[11] He was elected fellow of the American Academy of Arts and Science in 2020.[12]
References
edit- ^ "Howard Y. Chang, MD PhD". Stanford University Neurosciences Institute.
- ^ "Howard Y. Chang, MD, PhD". Howard Hughes Medical Institute. Retrieved January 10, 2020.
- ^ "Amgen taps Stanford's Howard Chang to take CSO reins from R&D chief Jay Bradner". Retrieved 21 November 2024.
- ^ "Curriculum Vitae: Howard Y. Chang". Stanford University. Archived from the original on December 5, 2005. Retrieved July 27, 2018.
- ^ "中研院院士解開「自體免疫疾病」之謎！張昭雄之子張元豪：罪魁禍首是RNA分子「Xist」". The Storm Media (in Chinese (Taiwan)). 4 February 2024. Retrieved 12 October 2024.
- ^ "Howard Y. Chang, MD PhD". Stanford University. Retrieved July 27, 2018.
- ^ Rinn, John L.; Kertesz, Michael; Wang, Jordon K.; Squazzo, Sharon L.; Xu, Xiao; Brugmann, Samantha A.; Goodnough, L. Henry; Helms, Jill A.; Farnham, Peggy J.; Segal, Eran; Chang, Howard Y. (June 2007). "Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs". Cell. 129 (7): 1311–1323. doi:10.1016/j.cell.2007.05.022. PMC 2084369.
- ^ Ahmed, Farooq (13 April 2021). "Profile of Howard Y. Chang". Proceedings of the National Academy of Sciences. 118 (15). doi:10.1073/pnas.2104246118. PMC 8053961.
- ^ "2018 NAS Award in Molecular Biology". National Academy of Sciences. Retrieved January 10, 2020.
- ^ King Faisal Prize 2024
- ^ Albany Medical Center Prize 2024
- ^ "Howard Y. Chang". American Academy of Arts & Sciences. Retrieved 2021-01-09.