HIV Tat-specific factor 1 is a protein that in humans is encoded by the HTATSF1 gene .[ 5] [ 6]
Whereas most DNA sequence-specific transcription factors increase the rate of initiation and interact with enhancer or promoter DNA, human immunodeficiency virus-1 (HIV-1) Tat predominantly stimulates elongation and interacts with the trans-acting responsive (TAR) RNA element. Tat is essential for HIV replication.[ 6]
HTATSF1 has also been shown to be involved in intron retention, and is associated with splicing of mRNAs that encode ribosomal proteins.[ 7] Nanog and KLF2 .[ 7]
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