Glycine dehydrogenase

For other uses, see Glycine dehydrogenase (disambiguation).

In enzymology, a glycine dehydrogenase (EC 1.4.1.10) is an enzyme that catalyzes the chemical reaction

glycine dehydrogenase
Identifiers
EC no.	1.4.1.10
CAS no.	37255-40-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

glycine + H₂O + NAD⁺ $\rightleftharpoons$ glyoxylate + NH₃ + NADH + H⁺

The 3 substrates of this enzyme are glycine, H₂O, and NAD⁺, whereas its 4 products are glyoxylate, NH₃, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glycine:NAD+ oxidoreductase (deaminating).

This should not be confused with:

the glycine dehydrogenase (decarboxylating), which is another name for the Glycine cleavage system P-protein (EC 1.4.4.2).

or the glycine dehydroganse (cyanide forming)(EC 1.4.99.5).

or the glycine dehydrogenase (cytochrome) (EC 1.4.2.1).

References

• GOLDMAN DS, WAGNER MJ (1962). "Enzyme systems in the mycobacteria. XIII. Glycine dehydrogenase and the glyoxylic acid cycle". Biochim. Biophys. Acta. 65 (2): 297–306. doi:10.1016/0006-3002(62)91048-X. PMID 13948749.