Codon reassignment is the biological process via which the genetic code of a cell is changed as a response to the environment. It may be caused by alternative tRNA aminoacylation, in which the cell modifies the target aminoacid of some particular type of transfer-RNA.[1] This process has been identified in bacteria, yeast and human cancer cells.[1]
In human cancer cells, codon reassignment can be triggered by tryptophan depletion, resulting in proteins where the tryptophan aminoacid is substituted by phenylalanine.[1]
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edit- ^ a b c Pataskar, Abhijeet; Champagne, Julien; Nagel, Remco; Kenski, Juliana; Laos, Maarja; Michaux, Justine; Pak, Hui Song; Bleijerveld, Onno B.; Mordente, Kelly; Navarro, Jasmine Montenegro; Blommaert, Naomi (March 2022). "Tryptophan depletion results in tryptophan-to-phenylalanine substitutants". Nature. 603 (7902): 721–727. Bibcode:2022Natur.603..721P. doi:10.1038/s41586-022-04499-2. ISSN 1476-4687. PMC 8942854. PMID 35264796. S2CID 247361552.
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