PDE4A

PDE4A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2QYK, 3I8V, 3TVX
Dynodwyr
Cyfenwau	PDE4A, DPDE2, PDE4, PDE46, phosphodiesterase 4A
Dynodwyr allanol	OMIM: 600126 HomoloGene: 4520 GeneCards: PDE4A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphoric diester hydrolase activity • cAMP binding • GO:0001948, GO:0016582 protein binding • hydrolase activity • 3',5'-cyclic-nucleotide phosphodiesterase activity • metal ion binding • 3',5'-cyclic-AMP phosphodiesterase activity Cydrannau o'r gell • cytoplasm • ruffle membrane • perinuclear region of cytoplasm • cytosol • cell projection • bilen • nucleoplasm • Cellbilen Prosesau biolegol • sensory perception of smell • regulation of cAMP-mediated signaling • cAMP catabolic process • regulation of protein kinase A signaling • GO:0072468 signal transduction • G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5141	n/a
Ensembl	ENSG00000065989	n/a
UniProt	P27815	n/a
RefSeq (mRNA)	NM_001111307 NM_001111308 NM_001111309 NM_001243121 NM_006202	n/a
RefSeq (protein)	NP_001104777 NP_001104778 NP_001104779 NP_001230050 NP_006193	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PDE4A yw PDE4A a elwir hefyd yn Phosphodiesterase 4A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19p13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PDE4A.

• PDE4
• DPDE2
• PDE46

Llyfryddiaeth

• "PGE 2 desensitizes β -agonist effect on human lung fibroblast-mediated collagen gel contraction through upregulating PDE4. ". Mediators Inflamm. 2013. PMID 24227907.
• "Conserved expression and functions of PDE4 in rodent and human heart. ". Basic Res Cardiol. 2011. PMID 21161247.
• "Loss of phosphodiesterase 4 in Parkinson disease: Relevance to cognitive deficits. ". Neurology. 2017. PMID 28701494.
• "Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners. ". Biochem J. 2017. PMID 27993970.
• "Key role of phosphodiesterase 4A (PDE4A) in autophagy triggered by yessotoxin.". Toxicology. 2015. PMID 25576684.