NACA

NACA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3LKX, 3MCB, 3MCE
Dynodwyr
Cyfenwau	NACA, NACA1, skNAC, HSD48, NAC-alpha, nascent polypeptide-associated complex alpha subunit, nascent polypeptide associated complex subunit alpha
Dynodwyr allanol	OMIM: 601234 HomoloGene: 136025 GeneCards: NACA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001105 transcription coactivator activity • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • cnewyllyn cell • nascent polypeptide-associated complex • extracellular exosome Prosesau biolegol • transcription, DNA-templated • GO:0009373 regulation of transcription, DNA-templated • protein transport • regulation of skeletal muscle fiber development • cardiac ventricle development • heart trabecula morphogenesis • positive regulation of cell proliferation involved in heart morphogenesis • GO:0022415 viral process • skeletal muscle tissue regeneration • protein biosynthesis • positive regulation of skeletal muscle tissue growth • negative regulation of striated muscle cell apoptotic process • GO:0015915 transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4666	n/a
Ensembl	ENSG00000196531	n/a
UniProt	Q13765	n/a
RefSeq (mRNA)	NM_001113201 NM_001113202 NM_001113203 NM_005594 NM_001320193 NM_001320194 NM_001365896	n/a
RefSeq (protein)	NP_001106672 NP_001106673 NP_001106674 NP_001307122 NP_001307123 NP_005585 NP_001106672 NP_001106673 NP_001106674 NP_001307122 NP_001307123 NP_005585	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NACA yw NACA a elwir hefyd yn Nascent polypeptide-associated complex subunit alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NACA.

• HSD48
• NACA1
• skNAC
• NAC-alpha

Llyfryddiaeth

• "Overexpression of the skNAC gene in human rhabdomyosarcoma cells enhances their differentiation potential and inhibits tumor cell growth and spreading. ". Clin Exp Metastasis. 2014. PMID 25209525.
• "alphaNAC depletion as an initiator of ER stress-induced apoptosis in hypoxia. ". Cell Death Differ. 2009. PMID 19609276.
• "NACA is a positive regulator of human erythroid-cell differentiation. ". J Cell Sci. 2005. PMID 15784678.
• "Investigation of alpha nascent polypeptide-associated complex functions in a human CD8(+) T cell ex vivo expansion model using antisense oligonucleotides. ". Immunology. 2004. PMID 15196207.
• "Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas.". Bone. 2003. PMID 12689679.