MAP2K5

MAP2K5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2NPT, 2O2V, 4IC7
Dynodwyr
Cyfenwau	MAP2K5, HsT17454, MAPKK5, MEK5, PRKMK5, mitogen-activated protein kinase kinase 5
Dynodwyr allanol	OMIM: 602520 HomoloGene: 115933 GeneCards: MAP2K5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein kinase activity • nucleotide binding • metal ion binding • kinase activity • GO:0001948, GO:0016582 protein binding • protein tyrosine kinase activity • ATP binding • protein serine/threonine kinase activity • MAP kinase kinase activity Cydrannau o'r gell • cytoplasm • cytosol • spindle • cnewyllyn cell • intracellular anatomical structure Prosesau biolegol • negative regulation of chemokine (C-X-C motif) ligand 2 production • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • phosphorylation • positive regulation of epithelial cell proliferation • cellular response to laminar fluid shear stress • cellular response to growth factor stimulus • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of response to cytokine stimulus • MAPK cascade • ERK5 cascade • negative regulation of cell migration involved in sprouting angiogenesis • protein phosphorylation • heart development • positive regulation of cell growth • peptidyl-tyrosine phosphorylation • negative regulation of heterotypic cell-cell adhesion • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • negative regulation of NF-kappaB transcription factor activity • GO:0072468 signal transduction • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • regulation of mitotic cell cycle • stress-activated protein kinase signaling cascade • activation of protein kinase activity • regulation of apoptotic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5607	n/a
Ensembl	ENSG00000137764	n/a
UniProt	Q13163	n/a
RefSeq (mRNA)	NM_001206804 NM_002757 NM_145160 NM_145161 NM_145162	n/a
RefSeq (protein)	NP_001193733 NP_002748 NP_660143	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAP2K5 yw MAP2K5 a elwir hefyd yn Dual-specificity mitogen-activated protein kinase kinase 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q23.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAP2K5.

• MEK5
• MAPKK5
• PRKMK5
• HsT17454

Llyfryddiaeth

• "[Effects of ERK5 MAPK signaling transduction pathway on the inhibition of genistein to breast cancer cells]. ". Wei Sheng Yan Jiu. 2006. PMID 16758967.
• "Identification of mitogen-activated protein kinase kinase as a chemoresistant pathway in MCF-7 cells by using gene expression microarray. ". Surgery. 2002. PMID 12219026.
• "MEK5 overexpression is associated with the occurrence and development of colorectal cancer. ". BMC Cancer. 2016. PMID 27160304.
• "The MAP2K5-linked SNP rs2241423 is associated with BMI and obesity in two cohorts of Swedish and Greek children. ". BMC Med Genet. 2012. PMID 22594783.
• "Mitogen/extracellular signal-regulated kinase kinase-5 promoter region polymorphisms affect the risk of sporadic colorectal cancer in a southern Chinese population.". DNA Cell Biol. 2012. PMID 21861603.