ERBB2

ERBB2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1MFG, 1MFL, 1MW4, 1N8Z, 1QR1, 1S78, 2A91, 2JWA, 2KS1, 2L4K, 3BE1, 3H3B, 3N85, 3PP0, 3RCD, 3MZW, 3WLW, 3WSQ, 4GFU, 4HRL, 4HRM, 4HRN, 2N2A
Dynodwyr
Cyfenwau	ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, erb-b2 receptor tyrosine kinase 2
Dynodwyr allanol	OMIM: 164870 HomoloGene: 3273 GeneCards: ERBB2
EC number	2.7.10.1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• ErbB-3 class receptor binding; • transferase activity; • nucleotide binding; • protein kinase activity; • protein dimerization activity; • growth factor binding; • RNA polymerase I core binding; • kinase activity; • protein C-terminus binding; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • protein heterodimerization activity; • transmembrane receptor protein tyrosine kinase activity; • protein tyrosine kinase activity; • protein phosphatase binding; • ATP binding; • transmembrane signaling receptor activity; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • receptor tyrosine kinase;
Cydrannau o'r gell	• integral component of membrane; • bilen; • myelin sheath; • receptor complex; • Cellbilen; • basolateral plasma membrane; • apical plasma membrane; • perinuclear region of cytoplasm; • endosome membrane; • GO:0016023 cytoplasmic vesicle; • cnewyllyn cell; • cytoplasm; • cytosol; • integral component of plasma membrane; • basal plasma membrane;
Prosesau biolegol	• positive regulation of protein phosphorylation; • peripheral nervous system development; • GO:0009373 regulation of transcription, DNA-templated; • negative regulation of immature T cell proliferation in thymus; • positive regulation of MAP kinase activity; • phosphorylation; • transmembrane receptor protein tyrosine kinase signaling pathway; • positive regulation of epithelial cell proliferation; • cellular response to growth factor stimulus; • wound healing; • oligodendrocyte differentiation; • regulation of angiogenesis; • positive regulation of translation; • transcription, DNA-templated; • nervous system development; • MAPK cascade; • protein phosphorylation; • heart development; • cell surface receptor signaling pathway; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • positive regulation of cell growth; • regulation of microtubule-based process; • neuromuscular junction development; • regulation of ERK1 and ERK2 cascade; • myelination; • protein autophosphorylation; • phosphatidylinositol 3-kinase signaling; • positive regulation of transcription by RNA polymerase I; • cell population proliferation; • positive regulation of transcription by RNA polymerase III; • motor neuron axon guidance; • enzyme linked receptor protein signaling pathway; • GO:0072468 signal transduction; • positive regulation of cell adhesion; • positive regulation of protein targeting to membrane; • ERBB2 signaling pathway; • phosphatidylinositol phosphate biosynthetic process; • GO:1901313 positive regulation of gene expression; • peptidyl-tyrosine phosphorylation; • regulation of cell motility; • cellular response to epidermal growth factor stimulus; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • negative regulation of ERBB signaling pathway; • positive regulation of protein kinase B signaling; • negative regulation of signal transduction; • cell differentiation; • negative regulation of apoptotic process; • positive regulation of ERK1 and ERK2 cascade; • GO:0007243 intracellular signal transduction; • positive regulation of cell population proliferation; • neuron differentiation; • positive regulation of MAPK cascade;
	Sources:Amigo / QuickGO
Orthologau
	2064
	n/a
	ENSG00000141736
	n/a
	P04626
	n/a
	NM_001005862; NM_001289936; NM_001289937; NM_001289938; NM_004448
	n/a
NP_001005862; NP_001276865; NP_001276866; NP_001276867; NP_004439;
	NP_001369711; NP_001369712; NP_001369713; NP_001369714; NP_001369715; NP_001369716; NP_001369717; NP_001369718; NP_001369719; NP_001369720; NP_001369721; NP_001369722; NP_001369723; NP_001369724; NP_001369725; NP_001369726; NP_001369727; NP_001369728; NP_001369729; NP_001369730; NP_001369731; NP_001369732; NP_001369733; NP_001369734; NP_001369735
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ERBB2 yw ERBB2 a elwir hefyd yn Erb-b2 receptor tyrosine kinase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ERBB2.

NEU
NGL
HER2
TKR1
CD340
HER-2
MLN*19
HER-2/neu

Llyfryddiaeth

"Evaluation of Expression of Human Epidermal Growth Factor Receptor 2 (HER2) in Gastric and Gastroesophageal Junction Adenocarcinoma Using IHC and Dual-ISH. ". Anticancer Res. 2018. PMID 29277796.
"Outcome Evaluation of HER2 Breast Cancer Patients with Limited Brain Metastasis. ". Anticancer Res. 2017. PMID 29187495.
"Prognostic value of tumour-infiltrating lymphocytes in small HER2-positive breast cancer. ". Eur J Cancer. 2017. PMID 29154173.
"Quantifying HER-2 expression on circulating tumor cells by ACCEPT. ". PLoS One. 2017. PMID 29084234.
"Vinorelbine Plus Gemcitabine or Cisplatin as First-line Treatment of HER2-negative Advanced Breast Cancer.". Anticancer Res. 2017. PMID 28982882.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ERBB2 - Cronfa NCBI

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[2]