CYP11A1

CYP11A1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3NA1, 3N9Y, 3N9Z, 3NA0
Dynodwyr
Cyfenwau	CYP11A1, CYP11A, CYPXIA1, P450SCC, cytochrome P450 family 11 subfamily A member 1
Dynodwyr allanol	OMIM: 118485 HomoloGene: 37347 GeneCards: CYP11A1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • iron ion binding • metal ion binding • monooxygenase activity • heme binding • GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • oxidoreductase activity • cholesterol monooxygenase (side-chain-cleaving) activity • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • bilen • mitochondrial matrix • mitocondria • mitochondrial inner membrane Prosesau biolegol • vitamin D metabolic process • C21-steroid hormone metabolic process • lipid metabolism • cholesterol metabolic process • C21-steroid hormone biosynthetic process • sterol metabolic process • steroid biosynthetic process • steroid metabolic process • glucocorticoid biosynthetic process • cellular response to peptide hormone stimulus • cortisol metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1583	n/a
Ensembl	ENSG00000140459 ENSG00000288362	n/a
UniProt	P05108	n/a
RefSeq (mRNA)	NM_001099773 NM_000781	n/a
RefSeq (protein)	NP_000772 NP_001093243	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CYP11A1 yw CYP11A1 a elwir hefyd yn Cytochrome P450 family 11 subfamily A member 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q24.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CYP11A1.

• CYP11A
• CYPXIA1
• P450SCC

Llyfryddiaeth

• "A Family-Based Association Study of CYP11A1 and CYP11B1 Gene Polymorphisms With Autism in Chinese Trios. ". J Child Neurol. 2016. PMID 26690694.
• "Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies. ". Biochemistry. 2015. PMID 26603348.
• "CYP11A1 microsatellite (tttta)n polymorphism in PCOS women from South India. ". J Assist Reprod Genet. 2014. PMID 24793009.
• "Transcriptome analysis of MENX-associated rat pituitary adenomas identifies novel molecular mechanisms involved in the pathogenesis of human pituitary gonadotroph adenomas. ". Acta Neuropathol. 2013. PMID 23756599.
• "Abnormal apoptosis of trophoblastic cells is related to the up-regulation of CYP11A gene in placenta of preeclampsia patients.". PLoS One. 2013. PMID 23555723.