CRK Dynodwyr Cyfenwau CRK Dynodwyr allanol OMIM: 164762 HomoloGene: 81850 GeneCards: CRK Ontoleg y genyn Gweithrediad moleciwlaidd • protein-macromolecule adaptor activity • protein domain specific binding • ephrin receptor binding • GO:0001948, GO:0016582 protein binding • enzyme binding • insulin-like growth factor receptor binding • cytoskeletal protein binding • scaffold protein binding • phosphotyrosine residue binding • SH3 domain binding • SH2 domain binding • protein self-association • protein phosphorylated amino acid binding • protein tyrosine kinase binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • Cellbilen • actin cytoskeleton • extracellular exosome • cnewyllyn cell • membrane raft • GO:0009327 protein-containing complex Prosesau biolegol • Fc-gamma receptor signaling pathway involved in phagocytosis • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • ephrin receptor signaling pathway • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • regulation of Rac protein signal transduction • vascular endothelial growth factor receptor signaling pathway • regulation of actin cytoskeleton organization • positive regulation of substrate adhesion-dependent cell spreading • response to yeast • positive regulation of smooth muscle cell migration • response to hepatocyte growth factor • response to hydrogen peroxide • negative regulation of natural killer cell mediated cytotoxicity • cellular response to transforming growth factor beta stimulus • cellular response to nitric oxide • response to peptide • cellular response to nerve growth factor stimulus • cellular response to insulin-like growth factor stimulus • cellular response to endothelin • regulation of cell shape • regulation of signal transduction • positive regulation of cell growth • regulation of protein binding • regulation of wound healing • negative regulation of wound healing • response to cholecystokinin • regulation of cell motility • negative regulation of cell motility • neuron migration • regulation of leukocyte migration • lipid metabolism • dendrite development • cytokine-mediated signaling pathway • hippocampus development • cerebral cortex development • establishment of cell polarity • regulation of cell adhesion mediated by integrin • helper T cell diapedesis • reelin-mediated signaling pathway • regulation of dendrite development • cell chemotaxis • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity • cerebellar neuron development • regulation of T cell migration Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[ 1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn CRK yw CRK a elwir hefyd yn CRK proto-oncogene, adaptor protein (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17p13.3.[ 2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CRK.
"TCR crosslinking promotes Crk adaptor protein binding to tyrosine-phosphorylated CD3ζ chain. ". Biochem Biophys Res Commun . 2017. PMID 28526413 . "17p13.3 microduplication including CRK leads to overgrowth and elevated growth factors: A case report. ". Eur J Med Genet . 2016. PMID 27633569 . "Binding Mechanism of the N-Terminal SH3 Domain of CrkII and Proline-Rich Motifs in cAbl. ". Biophys J . 2016. PMID 27332121 . "Reciprocal regulation of Abl kinase by Crk Y251 and Abi1 controls invasive phenotypes in glioblastoma. ". Oncotarget . 2015. PMID 26473374 . "Long-Range Energetic Changes Triggered by a Proline Switch in the Signal Adapter Protein c-CrkII. ". J Mol Biol . 2015. PMID 26456136 . 
