CRH

CRH
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3EHU, 3EHT, 1GOE
Dynodwyr
Cyfenwau	CRH, CRF, CRH1, corticotropin releasing hormone
Dynodwyr allanol	OMIM: 122560 HomoloGene: 599 GeneCards: CRH
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • hormone activity • corticotropin-releasing hormone receptor 1 binding • corticotropin-releasing hormone receptor 2 binding • GO:0001948, GO:0016582 protein binding • neuropeptide hormone activity • signaling receptor binding • corticotropin-releasing hormone activity Cydrannau o'r gell • cytoplasm • perikaryon • varicosity • extracellular region • soma • extracellular space Prosesau biolegol • adwaith i gocên • response to immobilization stress • positive regulation of cortisol secretion • steroid metabolic process • positive regulation of protein phosphorylation • negative regulation of luteinizing hormone secretion • positive regulation of cell death • associative learning • homeostasis yr ïon • lung development • diterpenoid metabolic process • response to corticosterone • female pregnancy • negative regulation of norepinephrine secretion • adrenal gland development • synaptic transmission, dopaminergic • negative regulation of cell death • negative regulation of gene expression • cellular response to dexamethasone stimulus • positive regulation of corticosterone secretion • response to estrogen • locomotory exploration behavior • regulation of NMDA receptor activity • regulation of serotonin secretion • positive regulation of calcium ion import • glucocorticoid biosynthetic process • GO:1901313 positive regulation of gene expression • positive regulation of digestive system process • genedigaeth • response to pain • positive regulation of circadian sleep/wake cycle, wakefulness • positive regulation of cell population proliferation • hypothalamus development • learning or memory • hormone-mediated apoptotic signaling pathway • positive regulation of insulin secretion involved in cellular response to glucose stimulus • response to ethanol • inflammatory response • negative regulation of circadian sleep/wake cycle, REM sleep • response to ether • positive regulation of behavioral fear response • GO:0072468 signal transduction • adwaith y celloedd i gocên • long-term potentiation • chemical synaptic transmission • negative regulation of epinephrine secretion • negative regulation of glucagon secretion • G protein-coupled receptor signaling pathway • negative regulation of systemic arterial blood pressure • positive regulation of cAMP-mediated signaling • positive regulation of corticotropin secretion Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1392	n/a
Ensembl	ENSG00000147571	n/a
UniProt	P06850	n/a
RefSeq (mRNA)	NM_000756	n/a
RefSeq (protein)	NP_000747	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CRH yw CRH a elwir hefyd yn Corticotropin releasing hormone (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8q13.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CRH.

• CRF
• CRH1

Llyfryddiaeth

• "Promoter Methylation Pattern Controls Corticotropin Releasing Hormone Gene Activity in Human Trophoblasts. ". PLoS One. 2017. PMID 28151936.
• "Differential Activation in Amygdala and Plasma Noradrenaline during Colorectal Distention by Administration of Corticotropin-Releasing Hormone between Healthy Individuals and Patients with Irritable Bowel Syndrome. ". PLoS One. 2016. PMID 27448273.
• "Corticotropin-releasing factor (CRF) system localization in human fetal heart. ". Hormones (Athens). 2016. PMID 27377597.
• "Brain disorders associated with corticotropin-releasing hormone expression in the placenta among children born before the 28th week of gestation. ". Acta Paediatr. 2016. PMID 26331704.
• "Cellular signaling protective against noise-induced hearing loss - A role for novel intrinsic cochlear signaling involving corticotropin-releasing factor?". Biochem Pharmacol. 2015. PMID 26074267.