Akin Osibogun

College of medicine, University of Lagos., Community Health and Primary Care, Faculty Member

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Prof Akin Osibogun is a Professor of Public Health at the College of Medicine, University of Lagos who served as the Chief Medical Director of the 800-bed Lagos University Teaching Hospital from 2006 to 2014. In that capacity, he oversaw the clinical and professional training of undergraduate and postgraduate medical doctors as well as 8 Schools providing basic and post-basic professional training to Nurses, Midwives, Health Information Officers, Dental Nurses, Medical Social Workers among others. He established at the Lagos University Teaching Hospital the first and only School of Basic Dental Nursing in Nigeria.He has had the opportunity of serving as a Short Term Consultant on Health System Strengthening to the WHO Geneva on various dates between 1993 and 2003, Visiting Fellow (Epidemiology) at the Liverpool School of Tropical Medicine in 1994, an International Fellow at the Andrija Stampar School of Public Health, University of Zagreb, Croatia in 1993, a Visiting Lecturer at the Andrija Stampar School of Public Health 1994-1997, and Special Consultant on PHC to the Honourable Minister of Health, Nigeria in 1998/1999. He enjoys his involvement in postgraduate training of health manpower and he currently pursues that as a member of the Faculty at the College of Medicine University of Lagos.

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Efficacy of Hexetidine, Thymol and Hydrogen Peroxide-Containing Oral Antiseptics in Reducing Sars-Cov-2 Virus in the Oral Cavity: A Pilot Study

West Africa Journal of Medicine

Background: Studies have demonstrated the role of sputum as a site of severe acute respiratory sy... more Background: Studies have demonstrated the role of sputum as a site of severe acute respiratory syndrome-coronavirus-2 (SARSCoV-2) transmission. However, there is limited literature on the virucidal efficacy of oral antiseptics against SARS-CoV-2 virus. This study investigated the virucidal efficacy of three oral-antiseptics compared to a placebo-control in the sputum of SARS-CoV-2 infected individuals. Methodology: A pilot study of adults with SARS-CoV-2 positive results, as determined by reverse transcription-polymerase chain reaction (RT-PCR) of <7 days. The oral antiseptics investigated were: Hexetidine (0.1% w/v); Thymol (0.063% w/v) and H2O2(1.5%) compared to de-mineralized sterile water (Placebo-control). The primary outcome measure was the proportion of negative RT-PCR results at 15-mins, 30-mins, 1-hour, 2-hours and 4-hours After Oral antiseptics Interventions (AOI) compared to the placebo-control. Statistical analysis was done using STATA 15.0 software with p-values of &...

High SARS-CoV-2 seroprevalence in Lagos, Nigeria with Robust Antibody and Cellular Immune Responses

Journal of clinical virology plus, Jun 1, 2023

High SARS-CoV-2 seroprevalence in Lagos, Nigeria with robust antibody and cellular responses

medRxiv (Cold Spring Harbor Laboratory), Dec 1, 2022

Background Early evidence suggested that the impact of the COVID-19 pandemic was less severe in A... more Background Early evidence suggested that the impact of the COVID-19 pandemic was less severe in Africa compared to other parts of the world. However, more recent studies indicate higher SARS-CoV-2 infection and COVID-19 mortality rates on the continent than previously documented. Research is needed to better understand SARS-CoV-2 seroprevalence and immunity in Africa. Methods Our collaboration with the Lagos State COVID-19 Taskforce, enabled secondary analyses of immune responses in healthcare workers (HCWs) and Oxford/AstraZeneca COVID-19 vaccine recipients from the general population across 5 local government areas (LGAs) in Lagos State, Nigeria. Western blots were used to simultaneously detect SARS-CoV-2 spike and nucleocapsid (N) antibodies and stimulation of peripheral blood mononuclear cells with N followed by an IFN-γ ELISA was used to examine T cell responses. Findings Antibody data demonstrated high SARS-CoV-2 seroprevalence of 71.6% (96/134) in HCWs and 54.8% (63/115) in the general population. Antibodies directed to only SARS-CoV-2 N, suggesting pre-existing coronavirus immunity, were seen in 10.4% (14/134) of HCWs and 20.0% (23/115) of the general population. T cell data showed that IFN-γ responses against SARS-CoV-2 N were robust in detecting exposure to the virus, demonstrating 87.5% sensitivity and 92.3% specificity. Interpretation All rights reserved. No reuse allowed without permission.

Akin Osibogun

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