Siddhartha Dan

PUNJAB TECHNICAL UNIVERSITY, JALANDHAR, PUNJAB, INDIA, Biotechnology, M.Tech

Followers

Following

Co-authors

Public Views

I'm pursuing M.Tech degree in the field of Biotechnology at I.K Gujral Punjab Technical University, Jalandhar-Punjab. My work is mainly focused on nanobiotechnology and to explore clinical research disease-related works. Formerly Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala (2016-2020), Minister of Human Resource development Student Coordinator (2017-2020), and Institute of Nuclear Medicine and Allied Science (DRDO), Delhi (2019-2020). He has published reviewed papers and chapters in reputed national and international journals and it’s also available online. He also has expertise in animal handling techniques, tissue processing, and histopathology. He is working on wound healing models in vivo. The in vivo models include excision wounds, incision wounds, and radiation burn on rat’s skin to assess the efficacy, toxicity, and molecular mechanism of the prepared formulations behind the wound healing.
Phone: 09817365257
Address: Jharkhand

less

Interests

Uploads

Papers by Siddhartha Dan

Influenza A (H1N1) in India: A systematic review of cases from 2010–2020

Influenza virus (H1N1) caused seasonal influenza, is an acute respiratory infection that spreads ... more Influenza virus (H1N1) caused seasonal influenza, is an acute respiratory infection that spreads to whole worldwide.The first case of influenza A virus pandemics in India came to light in May 2009 in Hyderabad city of Telangana.Human-to-human transmission led to considerable morbidity and mortality within the country until December.The total number of seasonal influenza cases in India from the year 2010 to 31 st July, 2020 is 1,73,488. Decreasing ambient temperature is often associated with influenza weather. The viral particle's ability to survive long term in cold temperatures also plays an important role. Besides, coagulation during winter serves as a co-contributing factor in facilitating the spread of the influenza virus.The environmental temperature leads to physical stress and energy loss due to thermal regulation, which weakens the immune system and thereby increases the host's likelihood of infection. The prevention of epidemics in India was possible only by quick and efficient measures taken by the Government.Soon after cases were registered at Pune, Maharashtra, and other places across the country, steps were taken to revise the guidelines for the control of the disease in India.Classification of cases in health facilities and home environments, classification of cases, providing treatment to appropriate persons, public education, and other appropriate measures proved to be very effective in due course of time. In this paper, we discussed the total cases and mortality due to seasonal influenza virus in the states and union territories in India from the year 2010 to the year 2020.

Download

Scholastic Conspectus Siddhartha Dan, 2021

Indigenous Therapeutics of Alzheimer: A Review of Ayurvedic Herbs from its Ethnobotany to Phytotherapy

Letters in Applied NanoBioScience, 2021

Ayurveda, often known as Ayurvedic medicine, is a customized system of the traditional system of ... more Ayurveda, often known as Ayurvedic medicine, is a customized system of the traditional system of medicine with historical roots in the Indian subcontinent. This alternative medicine system has been used for more than 5,000 years in India, and it is grounded on a holistic view of treatment that stimulates and supports equilibrium in diverse facets of human life: the body, soul, and mind. A great variety of herbs and plants are used in Ayurveda for numerous advantages; however, the popular Ayurvedic medicinal plants and formulations that are used to delay the aging of the human brain and improve memory consist of Ashwagandha (Withania somnifera), Turmeric (Curcuma longa), Brahmi (Bacopa monnieri), Shankhpushpi (Convolvulus pluricaulis, Evolvulus alsinoides, and other species), gotu kola (Centella asiatica), and guggulu (Commiphora mukul and correlated species) and a preparation identified as Brāhmī Ghṛita, containing Brahmi, Vacā (Acorus calamus), Kuṣṭha (Saussurea lappa), Shankhpushp...

Download

Current Perspective on Dominant Negative Mutations: Trends, Scope and Relevance

Biointerface Research in Applied Chemistry, 2020

Despite the advancements in tools and technologies implicated in identifying and characterizing n... more Despite the advancements in tools and technologies implicated in identifying and characterizing novel genes, there are still a significant number of unknown function proteins. Moreover, the practices employed in order to characterize such proteins have proven to be a futile exercise so far because of many limitations associated with such traditional approaches. Dominant-negative mutations have shown great promise in this direction as the introduction of mutation in the target protein may abolish the protein function and inhibit the function of the simultaneously expressed wild-type protein. These dominant mutations have broader applications in biological processes to study various proteins in terms of their functional aspects, etiological factors, and mechanism of action, paving the way to diagnose many dreadful diseases, including cancer. Considering these facts, the current review emphasizes utilizing the full potential of such dominant-negative mutations in deciphering protein fu...

Download

The Case Fatality Rate in COVID-19 Patients With Cardiovascular Disease: Global Health Challenge and Paradigm in the Current Pandemic

Current Pharmacology Reports, 2020

Purpose of Review Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is identified from... more Purpose of Review Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is identified from Wuhan, China, and has spread almost worldwide. Recently, the newly identified SARS-CoV-2 has been confirmed to kill millions of people worldwide and is dangerous to society health, survival, and livelihood. The people with cardiovascular problems are noticed as most common patients of coronavirus disease 2019 (COVID-19). There is a greater risk of mortality and morbidity in these patients than other patients of COVID-19. In the heart, expressed angiotensin-converting enzyme 2 (ACE2) and response effect of hyperactivity with angiotensin II associated to the renin-angiotensin mechanism are key factors of hypertension, atherosclerosis, and congestive heart failure. Recent Findings Mortality rates have been observed about 10.5% cases in patients with cardiovascular disease; however, a mortality rate of 52% was recorded in patients with heart failure, while 12% recovered ultimately. The occupancy of intense injury controlled by troponin elevation was a noteworthy factor in relation to mortality. Among 187 patients infected with SARS-CoV-2, about 35% were diagnosed with cardiovascular disease (CVD) history and 28% with raised troponin. Troponin elevation was identified more frequently (55%) in patients with cardiovascular diseases. Mortality rate in patients without cardiovascular diseases and normal troponin was 7.6%, normal troponin and cardiovascular disease with 13.3%, augmented troponin and without cardiovascular disease 37.5%, however 69.4% among cardiovascular disease and advanced troponin. Summary The study reflected a significant association of case fatality rate (CFR) to COVID-19 patients with cardiovascular diseases which supposed to be the most common dangerous risk factor and health challenge during the current pandemic situation.

Download

Incidence of COVID-19 and Its Correlation between Temperature and Population Density

Toxic Effect of Formaldehyde: A Systematic Review

Synergistic Approach of Graphene Oxide-Silver-Titanium Nanocomposite Film in Oral and Dental Studies: A New Paradigm of Infection Control in Dentistry

Nanoparticles have been used in numerous fields, various branches of science and engineering. The... more Nanoparticles have been used in numerous fields, various branches of science and engineering. These were used as a modification and to enhance the activity such as dentistry and oral investigation. The current survey uncovers that graphene oxide has been used to set up a variety of functionalized nanoparticles and progressed nanocomposites carriers. Graphene oxide shows potential in a variety of research examinations, for instance, tooth bleaching, antimicrobial activity, tooth erosion, teeth implants, toothaches, drug delivery at a specific site. All these usages of graphene oxide to biomedicine are excellent, and consoling Graphene oxide use in dental science has given amazing outcomes in antimicrobial activity, bone tissue building, regenerative dental, advancing dentistry biological materials, and in the treatment of oral cancer. The biocompatibilities of graphene oxide and its nanomaterial make them approaching units in bone regeneration, osseointegration, and cell multiplicati...

Download

Progression in Alzheimer’s Disease Correlates With Epigenetics and Cerebral Formaldehyde: From Potential Hereditary Mechanism and Environmental Factors to Therapeutic Measures

Current Pharmacology Reports

Strategies to Suppress Tumor Angiogenesis and Metastasis, Overcome Multi-Drug Resistance in Cancer, Target Telomerase and Apoptosis Pathways

Handbook of Research on Advancements in Cancer Therapeutics

Cancer has been a worldwide topic in the medical field for a very long time. As angiogenesis is e... more Cancer has been a worldwide topic in the medical field for a very long time. As angiogenesis is essential for tumor growth and metastasis, controlling tumor-associated angiogenesis is a promising tactic in limiting cancer progression. In cancer patients, multidrug resistance (MDR) is most widely used phenomenon by which cancer acquired resistance to chemotherapy. This resistance to chemotherapy occurs due to the formation of insulated tumor microenvironment which remains a major hurdle in the cure of various types of cancer. The mechanisms that cause malignant growth of cells include cell cycle control, signal transduction pathways, apoptosis, telomere stability, and interaction with the extracellular matrix. This chapter focuses on current strategies to suppress tumor angiogenesis for cancer therapy, various mechanisms involved in the development of MDR in cancer cells, which in turn will help us to identify possible strategies to overcome these MDR mechanisms and a variety of proc...

Recent Advancement in SARS-CoV-2 Diagnosis, Treatment, and Vaccine Formulation: a New Paradigm of Nanotechnology in Strategic Combating of COVID-19 Pandemic

Current Pharmacology Reports

Purpose of Review The coronavirus disease-2019 (COVID-19) is a global pandemic which has not been... more Purpose of Review The coronavirus disease-2019 (COVID-19) is a global pandemic which has not been seen in recent history, leaving behind deep socioeconomic damages and huge human losses with the disturbance in the healthcare sector. Despite the tremendous international effort and the launch of various clinical trials for the containment of this pandemic, no effective therapy has been proven yet. Recent Findings This review has highlighted the different traditional therapeutic techniques, along with the potential contribution of nanomedicine against the severe acute respiratory syndrome corovirus-2 (SARS-CoV-2). Repositioning of the drugs, such as remdesivir and chloroquine, is a rapid process for the reach of safe therapeutics, and the related clinical trials have determined effects against COVID-19. Various protein-based SARS-CoV-2 vaccine candidates have successfully entered clinical phases, determining positive results. The self-assembled and metallic nanovaccines mostly based on the antigenic properties of spike (S) protein are also approachable, feasible, and promising techniques for lowering the viral burden. Summary There are number of NP-based diagnostic systems have been reported for coronaviruses (CoVs) and specifically for SARS-CoV-2. However, extensive studies are still necessary and required for the nanoparticle (NP)-based therapy. Keywords COVID-19. SARS-CoV-2. Nanomedicine. Nanovaccines. Nano-based diagnosis This article is part of the Topical Collection on Clinical Pharmacology

Download