SMAP1

SMAP1
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 2CRR
Identifikatori
Aliasi	SMAP1
Vanjski ID-jevi	OMIM: 611372 MGI: 2138261 HomoloGene: 134676 GeneCards: SMAP1
Lokacija gena (čovjek) Hrom. Hromosom 6 (čovjek) Bend 6q13 Početak 70,667,776 bp Kraj 70,862,011 bp
Lokacija gena (miš) Hrom. Hromosom 1 (miš) Bend 1|1 A5 Početak 23,883,927 bp Kraj 23,961,398 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • clathrin binding • vezivanje iona metala • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity Ćelijska komponenta • citoplazma • ćelijska membrana • membrana Biološki proces • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • regulation of clathrin-dependent endocytosis • positive regulation of erythrocyte differentiation Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	60682	98366
Ensembl	ENSG00000112305	ENSMUSG00000026155
UniProt	Q8IYB5	Q91VZ6
RefSeq (mRNK)	NM_001044305 NM_001281439 NM_001281440 NM_021940	NM_001290683 NM_028534 NM_001357395
RefSeq (bjelančevina)	NP_001037770 NP_001268368 NP_001268369 NP_068759	NP_001277612 NP_082810 NP_001344324
Lokacija (UCSC)	Chr 6: 70.67 – 70.86 Mb	Chr 1: 23.88 – 23.96 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Stromski membranski pridruženi protein 1 je protein koji je kod ljudi kodiran genom SMAP1.

Protein kodiran ovim genom sličan je mišjem proteinu 1 povezanom sa stromskom membranom. Ova sličnost sugerira da je ovaj ljudski genski proizvod također tip II membranski glikoprotein uključen u eritropoetsku stimulacijsku aktivnost stromnih ćelija. Alternativna prerada rezultira u više varijanti transkripta koje kodiraju različite izoforme.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 467 aminokiselina, а molekulska težina 50.386 Da.

10		20		30		40		50
MATRSCREKA		QKLNEQHQLI		LSKLLREEDN		KYCADCEAKG		PRWASWNIGV
FICIRCAGIH		RNLGVHISRV		KSVNLDQWTA		EQIQCMQDMG		NTKARLLYEA
NLPENFRRPQ		TDQAVEFFIR		DKYEKKKYYD		KNAIAITNIS		SSDAPLQPLV
SSPSLQAAVD		KNKLEKEKEK		KKEEKKREKE		PEKPAKPLTA		EKLQKKDQQL
EPKKSTSPKK		AAEPTVDLLG		LDGPAVAPVT		NGNTTVPPLN		DDLDIFGPMI
SNPLPATVMP		PAQGTPSAPA		AATLSTVTSG		DLDLFTEQTT		KSEEVAKKQL
SKDSILSLYG		TGTIQQQSTP		GVFMGPTNIP		FTSQAPAAFQ		GFPSMGVPVP
AAPGLIGNVM		GQSPSMMVGM		PMPNGFMGNA		QTGVMPLPQN		VVGPQGGMVG
QMGAPQSKFG		LPQAQQPQWS		LSQMNQQMAG		MSISSATPTA		GFGQPSSTTA
GWSGSSSGQT		LSTQLWK

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

Dopunska literatura

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Tanabe K, Torii T, Natsume W, et al. (2005). "A novel GTPase-activating protein for ARF6 directly interacts with clathrin and regulates clathrin-dependent endocytosis". Mol. Biol. Cell. 16 (4): 1617–28. doi:10.1091/mbc.E04-08-0683. PMC 1073646. PMID 15659652.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Barragan I, Marcos I, Borrego S, Antiñolo G (2006). "Mutation screening of three candidate genes, ELOVL5, SMAP1 and GLULD1 in autosomal recessive retinitis pigmentosa". Int. J. Mol. Med. 16 (6): 1163–7. doi:10.3892/ijmm.16.6.1163. PMID 16273301.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.