MIR7-2

MIR7-2
Identifikatori
Aliasi	MIR7-2
Vanjski ID-jevi	GeneCards: MIR7-2
Lokacija gena (čovjek)
Hrom.	Hromosom 15 (čovjek)
Kraj	88,611,934 bp
Ortolozi
	407044
	n/a
	ENSG00000207703
	n/a
	n; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

MikroRNK 7-2 je nekodirajući genski proizvod, koji je kod ljudi kodiran genom MIR7-2.^[3]

Funkcija

mikroRNK (miRNK) su kratke (20-24 nt) nekodirajuće RNK koje su uključene u posttranskripcijske regulacije ekspresije gena u višećelijskih organizama s utjecajem na stabilnost i translaciju iRNK. miRNK se transkribiraju pomoću RNK-polimeraza II, kao dio zatvorenih i poliadenilovanih primarnih transkripata (pri-miRNK) koji, mogu biti za kodiranje ili nekodiranje proteina. Primarni transkript cijepa enzim Drosha-ribonukleaza III da bi se proizveo približno 70 nt prekursor miRNK matične petlje (pre-miRNK), koji se dalje cijepa citoplazmatskom Dicer-ribonukleazom da bi se stvorili proizvodi: zrela miRNK i antisens miRNK zvijezica (miRNK* ). Zrela miRNK ugrađena je u RNK-inducirani kompleks za utišavanje (RISC), koji prepoznaje ciljane iRNK preko nesavršenog uparivanje baze s miRNK i najčešće rezultira translacijskom inhibicijom ili destabilizacijom ciljne iRNK. RefSeq predstavlja predviđenu matičnu petlju mikroRNK.

Zastupljenost

Organizam	Taksonomija	Gen	Sličnost	Tip	Detalji
Miš (Mus musculus)	Mammalia	Mir7-2	77 (a)	Jedan-na-jedan	10:12627267-126; 7:78888277-78888373
Kokoš (Gallus gallus)	Aves	Gga-mir-7-2	71 (a)	Jedan-na-jedan	10:12627267-12627365
Gušter (Anolis carolinensis)	Reptilia	Aca-mir-7-3	65 (a)	Jedan-na-jedan	GL343844.1:159549-159658
Zebrica (Danio rerio)	Pisces	Dre-mir-7a-1 Dre-mir-7a-2	59 (a) 53 (a)	Jedan-na-mnogo	25:13574416-13574494 7:15327893-15327989

^[4]^[5]^[6]^[7]^[8]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000207703 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MicroRNA 7-2". Pristupljeno 18. 9. 2016.
^ Spatial expression analyses of the putative oncogene ciRS-7 in cancer reshape the microRNA sponge theory. (PMID 32917870) Kristensen LS … Hager H Nature communications 2020
^ MicroRNA-7 targets T-Box 2 to inhibit epithelial-mesenchymal transition and invasiveness in glioblastoma multiforme. (PMID 32861705) Pan CM … Chiu SC Cancer letters 2020
^ MicroRNA-7 Exerts Antiangiogenic Effect on Colorectal Cancer via ERK Signaling. (PMID 30909065) Fan X … Yuan S The Journal of surgical research 2019
^ MicroRNA-7 inhibition protects human osteoblasts from dexamethasone via activation of epidermal growth factor receptor signaling. (PMID 31313024) Fan JB … Zhao JN Molecular and cellular biochemistry 2019
^ Upregulation of microRNA-7 contributes to inhibition of the growth and metastasis of osteosarcoma cells through the inhibition of IGF1R. (PMID 31102265) Zhang Z … Wang G Journal of cellular physiology 2019

Dopunska literatura

Correa-Medina M, Bravo-Egana V, Rosero S, Ricordi C, Edlund H, Diez J, Pastori RL (2009). "MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas". Gene Expr. Patterns. 9 (4): 193–9. doi:10.1016/j.gep.2008.12.003. PMID 19135553.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000207703 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: MicroRNA 7-2". Pristupljeno 18. 9. 2016.

[4] Spatial expression analyses of the putative oncogene ciRS-7 in cancer reshape the microRNA sponge theory. (PMID 32917870) Kristensen LS … Hager H Nature communications 2020

[5] MicroRNA-7 targets T-Box 2 to inhibit epithelial-mesenchymal transition and invasiveness in glioblastoma multiforme. (PMID 32861705) Pan CM … Chiu SC Cancer letters 2020

[6] MicroRNA-7 Exerts Antiangiogenic Effect on Colorectal Cancer via ERK Signaling. (PMID 30909065) Fan X … Yuan S The Journal of surgical research 2019

[7] MicroRNA-7 inhibition protects human osteoblasts from dexamethasone via activation of epidermal growth factor receptor signaling. (PMID 31313024) Fan JB … Zhao JN Molecular and cellular biochemistry 2019

[8] Upregulation of microRNA-7 contributes to inhibition of the growth and metastasis of osteosarcoma cells through the inhibition of IGF1R. (PMID 31102265) Zhang Z … Wang G Journal of cellular physiology 2019

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