S Wikipedije, slobodne enciklopedije
Jedini protein F-kutije 24 je protein koji je kod ljudi kodiran genom FBXO24 .[ 5] [ 6] [ 7]
Dužina polipeptidnog lanca je 580 aminokiselina , а molekulska težina 64.889 Da .[ 8]
10 20 30 40 50 MGEKAVPLLR RRRVKRSCPS CGSELGVEEK RGKGNPISIQ LFPPELVEHI ISFLPVRDLV ALGQTCRYFH EVCDGEGVWR RICRRLSPRL QDQGSGVRPW KRAAILNYTK GLYFQAFGGR RRCLSKSVAP LLAHGYRRFL PTKDHVFILD YVGTLFFLKN ALVSTLGQMQ WKRACRYVVL CRGAKDFASD PRCDTVYRKY LYVLATREPQ EVVGTTSSRA CDCVEVYLQS SGQRVFKMTF HHSMTFKQIV LVGQETQRAL LLLTEEGKIY SLVVNETQLD QPRSYTVQLA LRKVSHYLPH LRVACMTSNQ SSTLYVTDQG GVYFEVHTPG VYRDLFGTLQ AFDPLDQQMP LALSLPAKIL FCALGYNHLG LVDEFGRIFM QGNNRYGQLG TGDKMDRGEP TQVCYLQRPI TLWCGLNHSL VLSQSSEFSK ELLGCGCGAG GRLPGWPKGS ASFVKLQVKV PLCACALCAT RECLYILSSH DIEQHAPYRH LPASRVVGTP EPSLGARAPQ DPGGMAQACE EYLSQIHSCQ TLQDRTEKMK EIVGWMPLMA AQKDFFWEAL DMLQRAEGGG GGVGPPAPET
Ovaj gen kodira člana porodice proteina F-kutije koju karakterizira približno 40-aminokiselinski motiv, F-kutija. Proteini F-kutije čine jednu od četiri podjedinice kompleksa proteinskih ubikvitin -ligaza zvanih SCF (SKP1-culin-F-kutija), koji funkcioniraju u ubikvitinaciji ovisnoj o fosforilaciji . Proteini F-kutije podijeljeni su u tri klase: Fbws koji sadrže domene WD-40, Fbls koji sadrže leucin -bogate ponavljanja i Fbxs koji sadrže ili različite module interakcija protein-protein ili bez prepoznatljivih motiva. Protein kodiran ovim genom pripada klasi Fbx. Alternativna prerada ovog gena generira dvije varijante transkripta .[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000106336 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000089984 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins" . Curr Biol . 9 (20): 1177–9. doi :10.1016/S0960-9822(00)80020-2 PMID 10531035 . S2CID 7467493 . ^ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins" . Curr Biol . 9 (20): 1180–2. doi :10.1016/S0960-9822(00)80021-4 PMID 10531037 . S2CID 14341845 . ^ a b "Entrez Gene: FBXO24 F-box protein 24" .^ "UniProt, O75426" (jezik: англ.). Pristupljeno 25. 9. 2021 .CS1 održavanje: nepoznati jezik (link )
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