CCL11

CCL11
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1EOT, 2EOT, 2MPM
Identifikatori
Aliasi	CCL11
Vanjski ID-jevi	OMIM: 601156 MGI: 103576 HomoloGene: 7929 GeneCards: CCL11
Lokacija gena (čovjek)
Hrom.	Hromosom 17 (čovjek)
Kraj	34,288,334 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	81,953,781 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• cytokine activity; • GO:0001948, GO:0016582 vezivanje za proteine; • chemokine activity; • CCR3 chemokine receptor binding; • protein dimerization activity; • receptor ligand activity; • CCR chemokine receptor binding;
Ćelijska komponenta	• extracellular region; • Vanćelijsko; • intracellular anatomical structure;
Biološki proces	• G protein-coupled receptor signaling pathway; • positive regulation of endothelial cell proliferation; • positive regulation of actin filament polymerization; • response to interleukin-4; • branching involved in mammary gland duct morphogenesis; • monocyte chemotaxis; • actin filament organization; • positive regulation of cell migration; • chemokine-mediated signaling pathway; • response to interleukin-13; • cellular response to tumor necrosis factor; • response to virus; • cellular calcium ion homeostasis; • mast cell chemotaxis; • neutrophil chemotaxis; • positive regulation of angiogenesis; • mammary duct terminal end bud growth; • Hemotaksija; • protein phosphorylation; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • Ćelijska adhezija; • cytoskeleton organization; • cellular response to interleukin-1; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor; • positive regulation of ERK1 and ERK2 cascade; • regulation of cell shape; • cellular response to interferon-gamma; • lymphocyte chemotaxis; • response to radiation; • inflammatory response; • chronic inflammatory response; • GO:0072468 Transdukcija signala; • eosinophil chemotaxis; • antimicrobial humoral immune response mediated by antimicrobial peptide; • regulation of signaling receptor activity; • cytokine-mediated signaling pathway; • ERK1 and ERK2 cascade;
	Izvori:Amigo / QuickGO
Ortolozi
	6356
	20292
	ENSG00000172156
	ENSMUSG00000020676
	P51671
	P48298
	NM_002986
	NM_011330
	NP_002977
	NP_035460
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

CC motivni hemokin 11, znan i kao eozinofilni
hemo-
taksijski protein
i eotaksin-1 je protein koji je kod ljudi kodiran genom CCL11. Ovaj gen ima tri egzona i nalazi se na hromosomu 17.^[5]^[6]

Sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Dužina peptidnog lanca je 97
aminokiselina,
a molekulska težina 10.732 Da.^[7]

10		20		30		40		50
MKVSAALLWL		LLIAAAFSPQ		GLAGPASVPT		TCCFNLANRK		IPLQRLESYR
RITSGKCPQK		AVIFKTKLAK		DICADPKKKW		VQDSMKYLDQ		KSPTPKP

Funkcija

CCL11 je mali citokin koji pripada porodici CC hemokina. CCL11 selektivno regrutuje eozinofile, inducirajući njihovu hemotaksiju, te je zato upleten u alergijske odgovore.^[8]^[9]^[10] Efekti CCL11 posreduju se njegovim vezanjem na receptor povezan sa G-proteinima, poznat kao hemokinski receptor. Hemokinski receptori za koje je CCL11 ligand uključuju CCR2,^[11] CCR3^[5] i CCR5.^[11] Međutim, utvrđeno je da eotaksin-1 (CCL11) ima visok stepen selektivnosti za svoj receptor, tako da je neaktivan na neutrofil imai monocitima, koji ne eksprimiraju CCR3.^[12]

Klinički značaj

Povećani nivoi CCL11 u krvnoj plazmi povezani su sa starenjem miševa i ljudi.^[13] Pored toga, pokazano je da izlaganje mladih miševa CCL11-u ili krvnoj plazmi starijih miševa smanjuje njihovu neurogenezu i kognitivne performanse na ponašanje za koje se smatra da ovise o neurogenezi u hipokampusu.^[13]

U sadašnjih korisnika kanabisa utvrđene su veće koncentracije CCL11 u plazmi, u odnosu na ranije korisnike i one koji nikada nisu koristili. CCL11 je također pronađen u većim koncentracijama kod ljudi koji pate od shizofrenije; kanabis je poznati pokretač shizofrenije.^[14]

Također je biomarker za CTE ili sindroma opojnog udara.^[15]

Tokom upala kostiju, CCL11 i CCR3 su regulirani. To je povezano s povećanjem aktivnosti osteoklasta.^[16]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172156 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020676 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O (Mar 1996). "Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3". The Journal of Biological Chemistry. 271 (13): 7725–30. doi:10.1074/jbc.271.13.7725. PMID 8631813.
^ Hein H, Schlüter C, Kulke R, Christophers E, Schröder JM, Bartels J (Aug 1997). "Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene". Biochemical and Biophysical Research Communications. 237 (3): 537–42. doi:10.1006/bbrc.1997.7169. PMID 9299399.
^ "UniProt, P51671". Pristupljeno 28. 6. 2021.
^ Jose PJ, Griffiths-Johnson DA, Collins PD, Walsh DT, Moqbel R, Totty NF, Truong O, Hsuan JJ, Williams TJ (Mar 1994). "Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation". The Journal of Experimental Medicine. 179 (3): 881–7. doi:10.1084/jem.179.3.881. PMC 2191401. PMID 7509365.
^ Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR (Feb 1996). "Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils". The Journal of Clinical Investigation. 97 (3): 604–12. doi:10.1172/JCI118456. PMC 507095. PMID 8609214.
^ Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD (Apr 1996). "Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia". Nature Medicine. 2 (4): 449–56. doi:10.1038/nm0496-449. PMID 8597956. S2CID 25571283.
^ ^a ^b Ogilvie P, Bardi G, Clark-Lewis I, Baggiolini M, Uguccioni M (Apr 2001). "Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5". Blood. 97 (7): 1920–4. doi:10.1182/blood.V97.7.1920. PMID 11264152.
^ Baggiolini M, Dewald B, Moser B (1997). "Human chemokines: an update". Annual Review of Immunology. 15: 675–705. doi:10.1146/annurev.immunol.15.1.675. PMID 9143704.
^ ^a ^b Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, et al. (Sep 2011). "The ageing systemic milieu negatively regulates neurogenesis and cognitive function". Nature. 477 (7362): 90–4. doi:10.1038/nature10357. PMC 3170097. PMID 21886162.
^ Fernandez-Egea E, Scoriels L, Theegala S, Giro M, Ozanne SE, Burling K, Jones PB (Oct 2013). "Cannabis use is associated with increased CCL11 plasma levels in young healthy volunteers". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 46: 25–8. doi:10.1016/j.pnpbp.2013.06.011. PMID 23820464. S2CID 207410464.
^ Cherry JD, Stein TD, Tripodis Y, Alvarez VE, Huber BR, Au R, Kiernan PT, Daneshvar DH, Mez J, Solomon TM, Alosco ML, McKee AC (2017). "CCL11 is increased in the CNS in chronic traumatic encephalopathy but not in Alzheimer's disease". PLOS ONE. 12 (9): e0185541. doi:10.1371/journal.pone.0185541. PMC 5614644. PMID 28950005. Sažetak – LabEquipment.
^ Kindstedt E, Holm CK, Sulniute R, Martinez-Carrasco I, Lundmark R, Lundberg P (juli 2017). "CCL11, a novel mediator of inflammatory bone resorption". Scientific Reports. 7 (1): 5334. doi:10.1038/s41598-017-05654-w. PMC 5509729. PMID 28706221.

Vanjski linkovi

Lokacija ljudskog genoma CCL11 i stranica sa detaljima o genu CCL11 u UCSC Genome Browseru.

Dopunska literatura

Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD (Apr 1996). "Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia". Nature Medicine. 2 (4): 449–56. doi:10.1038/nm0496-449. PMID 8597956. S2CID 25571283.
Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR (Feb 1996). "Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils". The Journal of Clinical Investigation. 97 (3): 604–12. doi:10.1172/JCI118456. PMC 507095. PMID 8609214.
Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O (Mar 1996). "Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3". The Journal of Biological Chemistry. 271 (13): 7725–30. doi:10.1074/jbc.271.13.7725. PMID 8631813.
Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS (maj 1996). "Cloning, expression, and characterization of the human eosinophil eotaxin receptor". The Journal of Experimental Medicine. 183 (5): 2349–54. doi:10.1084/jem.183.5.2349. PMC 2192548. PMID 8642344.
Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, Gerard N, Gerard C, Sodroski J (Jun 1996). "The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates". Cell. 85 (7): 1135–48. doi:10.1016/S0092-8674(00)81313-6. PMID 8674119. S2CID 16198200.
Ponath PD, Qin S, Post TW, Wang J, Wu L, Gerard NP, Newman W, Gerard C, Mackay CR (Jun 1996). "Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils". The Journal of Experimental Medicine. 183 (6): 2437–48. doi:10.1084/jem.183.6.2437. PMC 2192612. PMID 8676064.
Bartels J, Schlüter C, Richter E, Noso N, Kulke R, Christophers E, Schröder JM (Aug 1996). "Human dermal fibroblasts express eotaxin: molecular cloning, mRNA expression, and identification of eotaxin sequence variants". Biochemical and Biophysical Research Communications. 225 (3): 1045–51. doi:10.1006/bbrc.1996.1292. PMID 8780731.
Garcia-Zepeda EA, Rothenberg ME, Weremowicz S, Sarafi MN, Morton CC, Luster AD (maj 1997). "Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine". Genomics. 41 (3): 471–6. doi:10.1006/geno.1997.4656. PMID 9169149.
Hein H, Schlüter C, Kulke R, Christophers E, Schröder JM, Bartels J (Aug 1997). "Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene". Biochemical and Biophysical Research Communications. 237 (3): 537–42. doi:10.1006/bbrc.1997.7169. PMID 9299399.
Nibbs RJ, Wylie SM, Yang J, Landau NR, Graham GJ (Dec 1997). "Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6". The Journal of Biological Chemistry. 272 (51): 32078–83. doi:10.1074/jbc.272.51.32078. PMID 9405404.
Rubbert A, Combadiere C, Ostrowski M, Arthos J, Dybul M, Machado E, Cohn MA, Hoxie JA, Murphy PM, Fauci AS, Weissman D (Apr 1998). "Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry". Journal of Immunology. 160 (8): 3933–41. PMID 9558100.
Noso N, Bartels J, Mallet AI, Mochizuki M, Christophers E, Schröder JM (Apr 1998). "Delayed production of biologically active O-glycosylated forms of human eotaxin by tumor-necrosis-factor-alpha-stimulated dermal fibroblasts". European Journal of Biochemistry / FEBS. 253 (1): 114–22. doi:10.1046/j.1432-1327.1998.2530114.x. PMID 9578468.
Crump MP, Rajarathnam K, Kim KS, Clark-Lewis I, Sykes BD (Aug 1998). "Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation". The Journal of Biological Chemistry. 273 (35): 22471–9. doi:10.1074/jbc.273.35.22471. PMID 9712872.
Sabroe I, Hartnell A, Jopling LA, Bel S, Ponath PD, Pease JE, Collins PD, Williams TJ (Mar 1999). "Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways". Journal of Immunology. 162 (5): 2946–55. PMID 10072545.
Jinquan T, Quan S, Feili G, Larsen CG, Thestrup-Pedersen K (Apr 1999). "Eotaxin activates T cells to chemotaxis and adhesion only if induced to express CCR3 by IL-2 together with IL-4". Journal of Immunology. 162 (7): 4285–92. PMID 10201960.
Klein RS, Williams KC, Alvarez-Hernandez X, Westmoreland S, Force T, Lackner AA, Luster AD (Aug 1999). "Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS". Journal of Immunology. 163 (3): 1636–46. PMID 10415069.
Blanpain C, Migeotte I, Lee B, Vakili J, Doranz BJ, Govaerts C, Vassart G, Doms RW, Parmentier M (Sep 1999). "CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist". Blood. 94 (6): 1899–905. doi:10.1182/blood.V94.6.1899. PMID 10477718.
Zhang J, Lathbury LJ, Salamonsen LA (Feb 2000). "Expression of the chemokine eotaxin and its receptor, CCR3, in human endometrium". Biology of Reproduction. 62 (2): 404–11. doi:10.1095/biolreprod62.2.404. PMID 10642580. S2CID 28214811.
Kampen GT, Stafford S, Adachi T, Jinquan T, Quan S, Grant JA, Skov PS, Poulsen LK, Alam R (Mar 2000). "Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases". Blood. 95 (6): 1911–7. doi:10.1182/blood.V95.6.1911. PMID 10706854.
Huber MA, Kraut N, Addicks T, Peter RU (Mar 2000). "Cell-type-dependent induction of eotaxin and CCR3 by ionizing radiation". Biochemical and Biophysical Research Communications. 269 (2): 546–52. doi:10.1006/bbrc.2000.2287. PMID 10708591.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172156 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020676 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8631813-5] Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O (Mar 1996). "Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3". The Journal of Biological Chemistry. 271 (13): 7725–30. doi:10.1074/jbc.271.13.7725. PMID 8631813.

[pmid9299399-6] Hein H, Schlüter C, Kulke R, Christophers E, Schröder JM, Bartels J (Aug 1997). "Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene". Biochemical and Biophysical Research Communications. 237 (3): 537–42. doi:10.1006/bbrc.1997.7169. PMID 9299399.

[UniProt-7] "UniProt, P51671". Pristupljeno 28. 6. 2021.

[pmid7509365-8] Jose PJ, Griffiths-Johnson DA, Collins PD, Walsh DT, Moqbel R, Totty NF, Truong O, Hsuan JJ, Williams TJ (Mar 1994). "Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation". The Journal of Experimental Medicine. 179 (3): 881–7. doi:10.1084/jem.179.3.881. PMC 2191401. PMID 7509365.

[pmid8609214-9] Ponath PD, Qin S, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi X, Gonzalo JA, Newman W, Gutierrez-Ramos JC, Mackay CR (Feb 1996). "Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils". The Journal of Clinical Investigation. 97 (3): 604–12. doi:10.1172/JCI118456. PMC 507095. PMID 8609214.

[pmid8597956-10] Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD (Apr 1996). "Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia". Nature Medicine. 2 (4): 449–56. doi:10.1038/nm0496-449. PMID 8597956. S2CID 25571283.

[pmid11264152-11] Ogilvie P, Bardi G, Clark-Lewis I, Baggiolini M, Uguccioni M (Apr 2001). "Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5". Blood. 97 (7): 1920–4. doi:10.1182/blood.V97.7.1920. PMID 11264152.

[pmid9143704-12] Baggiolini M, Dewald B, Moser B (1997). "Human chemokines: an update". Annual Review of Immunology. 15: 675–705. doi:10.1146/annurev.immunol.15.1.675. PMID 9143704.

[pmid21886162-13] Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, et al. (Sep 2011). "The ageing systemic milieu negatively regulates neurogenesis and cognitive function". Nature. 477 (7362): 90–4. doi:10.1038/nature10357. PMC 3170097. PMID 21886162.

[pmid23820464-14] Fernandez-Egea E, Scoriels L, Theegala S, Giro M, Ozanne SE, Burling K, Jones PB (Oct 2013). "Cannabis use is associated with increased CCL11 plasma levels in young healthy volunteers". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 46: 25–8. doi:10.1016/j.pnpbp.2013.06.011. PMID 23820464. S2CID 207410464.

[pmid28950005-15] Cherry JD, Stein TD, Tripodis Y, Alvarez VE, Huber BR, Au R, Kiernan PT, Daneshvar DH, Mez J, Solomon TM, Alosco ML, McKee AC (2017). "CCL11 is increased in the CNS in chronic traumatic encephalopathy but not in Alzheimer's disease". PLOS ONE. 12 (9): e0185541. doi:10.1371/journal.pone.0185541. PMC 5614644. PMID 28950005. Sažetak – LabEquipment.

[pmid28706221-16] Kindstedt E, Holm CK, Sulniute R, Martinez-Carrasco I, Lundmark R, Lundberg P (juli 2017). "CCL11, a novel mediator of inflammatory bone resorption". Scientific Reports. 7 (1): 5334. doi:10.1038/s41598-017-05654-w. PMC 5509729. PMID 28706221.

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