BCAS2

BCAS2
Identifikatori
Aliasi	BCAS2
Vanjski ID-jevi	OMIM: 605783 MGI: 1915433 HomoloGene: 4291 GeneCards: BCAS2
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	114,581,629 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	103,086,482 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• Replikacijski protein A; • catalytic step 2 spliceosome; • spliceosomal complex; • Jedarce; • precatalytic spliceosome; • Prp19 complex; • nukleoplazma; • jedro; • centrosom; • nuclear speck; • U2-type catalytic step 2 spliceosome;
Biološki proces	• RNA splicing, via transesterification reactions; • mRNA processing; • Prerada RNK; • mRNA splicing, via spliceosome;
	Izvori:Amigo / QuickGO
Ortolozi
	10286
	68183
	ENSG00000116752
	ENSMUSG00000005687
	O75934
	Q9D287
	NM_005872
	NM_026602; NM_001356330; NM_001356331
	NP_005863
	NP_080878; NP_001343259; NP_001343260
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Pre-iRNK-preradni faktor SPF27 jest protein koji je kod ljudi kodiran genom BCAS2 sa hromosoma 1.^[5]^[6]^[7]

Amiokiselininska sekvenca

Dužina polipeptidnog lanca je 225 aminokiselina, a molekulska težina 26.131 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAGTGLVAGE	VVVDALPYFD	QGYEAPGVRE	AAAALVEEET	RRYRPTKNYL
SYLTAPDYSA	FETDIMRNEF	ERLAARQPIE	LLSMKRYELP	APSSGQKNDI
TAWQECVNNS	MAQLEHQAVR	IENLELMSQH	GCNAWKVYNE	NLVHMIEHAQ
KELQKLRKHI	QDLNWQRKNM	QLTAGSKLRE	MESNWVSLVS	KNYEIERTIV
QLENEIYQIK	QQHGEANKEN	IRQDF

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116752 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005687 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M (Oct 1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529. S2CID 585778.
^ Nagasaki K, Maass N, Manabe T, Hanzawa H, Tsukada T, Kikuchi K, Yamaguchi K (Aug 1999). "Identification of a novel gene, DAM1, amplified at chromosome 1p13.3-21 region in human breast cancer cell lines". Cancer Lett. 140 (1–2): 219–26. doi:10.1016/S0304-3835(99)00091-9. PMID 10403562.
^ "Entrez Gene: BCAS2 breast carcinoma amplified sequence 2".
^ "UniProt, O75934" (jezik: engleski). Pristupljeno 21. 11. 2021.

Dopunska literatura

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Qi C, Zhu YT, Chang J, et al. (2005). "Potentiation of estrogen receptor transcriptional activity by breast cancer amplified sequence 2". Biochem. Biophys. Res. Commun. 328 (2): 393–8. doi:10.1016/j.bbrc.2004.12.187. PMID 15694360.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Lee S, Ha S, Chung M, et al. (2003). "Mouse DAM1 regulates pro-apoptotic activity of BLK in mammary epithelial cells". Cancer Lett. 188 (1–2): 121–6. doi:10.1016/S0304-3835(02)00055-1. PMID 12406557.
Maass N, Rösel F, Schem C, et al. (2002). "Amplification of the BCAS2 gene at chromosome 1p13.3-21 in human primary breast cancer". Cancer Lett. 185 (2): 219–23. doi:10.1016/S0304-3835(02)00286-0. PMID 12169396.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

Vanjski linkovi

BCAS2 lokacija ljudskog genoma UCSC Genome Browser.

BCAS2 detalji ljudskog genoma u UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116752 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005687 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9731529-5] Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M (Oct 1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529. S2CID 585778.

[pmid10403562-6] Nagasaki K, Maass N, Manabe T, Hanzawa H, Tsukada T, Kikuchi K, Yamaguchi K (Aug 1999). "Identification of a novel gene, DAM1, amplified at chromosome 1p13.3-21 region in human breast cancer cell lines". Cancer Lett. 140 (1–2): 219–26. doi:10.1016/S0304-3835(99)00091-9. PMID 10403562.

[entrez-7] "Entrez Gene: BCAS2 breast carcinoma amplified sequence 2".

[UniProt-8] "UniProt, O75934" (jezik: engleski). Pristupljeno 21. 11. 2021.

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