Papers by Meghraj Singh Baghel
bioRxiv (Cold Spring Harbor Laboratory), Jun 29, 2024
doi: bioRxiv preprint Highlights • Loss of TDP-43 repression of cryptic exons is necessary for ca... more doi: bioRxiv preprint Highlights • Loss of TDP-43 repression of cryptic exons is necessary for caspase 3-dependent endoproteolysis of tau at D421 in the mouse brain and human iPSC-derived cortical neurons. • The level of caspase 3-dependent cleavage of tau is a major determinant of the vulnerability of mouse brain neurons lacking TDP-43. • In a novel mouse model of multiple etiology dementia, TDP-43 loss-of-function exacerbates tauopathy-dependent brain atrophy by sensitizing vulnerable neurons to caspase 3-mediated endoproteolysis of tau to drive tauopathy. • In human tauopathies with co-pathology of TDP-43, dysfunction of TDP-43 may promote caspase 3-dependent cleavage of endogenous tau in vulnerable neurons and exacerbate tauopathy-dependent neurodegeneration.
Biotechnology and Genetic Engineering Reviews
Journal of Neuroscience Research
Mitochondria are one of the essential cellular organelles. Apart from being considered as the pow... more Mitochondria are one of the essential cellular organelles. Apart from being considered as the powerhouse of the cell, mitochondria have been widely known to regulate redox reaction, inflammation, cell survival, cell death, metabolism, etc., and are implicated in the progression of numerous disease conditions including neurodegenerative diseases. Since brain is an energy‐demanding organ, mitochondria and their functions are important for maintaining normal brain homeostasis. Alterations in mitochondrial gene expression, mutations, and epigenetic modification contribute to inflammation and neurodegeneration. Dysregulation of reactive oxygen species production by mitochondria and aggregation of proteins in neurons leads to alteration in mitochondria functions which further causes neuronal death and progression of neurodegeneration. Pharmacological studies have prioritized mitochondria as a possible drug target in the regulation of neurodegenerative diseases. Therefore, the present revi...
Annals of Neurosciences, 2019
Background: Exposure to adverse environmental conditions such as toxic chemicals, viral infection... more Background: Exposure to adverse environmental conditions such as toxic chemicals, viral infections, and even stress during pregnancy or early life may disrupt the development of normal brain and its functioning leading to incidence of neurodevelopmental disorders at later stages of life. Recently, we reported that poly (I:C) exposure altered synaptic plasticity protein level and impaired memory through activation of microglia cells. Purpose: As epigenetic modifications are involved in memory formation, we have studied methylation of DNA and acetylation of histone at promoters of synaptic plasticity genes in the brain of rats exposed to poly (I:C) during early life. Methods: One dose of poly (I:C) (5 mg/kg bw) was intraperitoneally injected to rat pups on postnatal seventh day. A set of pups exposed to vehicle was included as control. In order to assess methylation of DNA and acetylation of histone at synaptic plasticity gene promoter, we performed qPCR after methylated DNA immunopre...
Neurobiology of Learning and Memory, 2018
exposure to poly (I:C) impairs learning and memory through changes in synaptic plasticity gene ex... more exposure to poly (I:C) impairs learning and memory through changes in synaptic plasticity gene expression in developing rat brain,
Models, Molecules and Mechanisms in Biogerontology, 2019
With global rise in elderly population, there is an increase in the incidence of age-related neur... more With global rise in elderly population, there is an increase in the incidence of age-related neurological problems. Hence, achieving healthy aging is a great challenge for scientists, medical practitioners, and social workers. Aging is characterized by enormous remarkable changes in the brain at morphological, cellular, biochemical, and physiological levels leading to cognitive impairment. A key player in this process is reactive oxygen species (ROS) which causes intracellular damage leading to progressive loss of control over biological homeostasis, oxidative stress, and thereby degeneration of different neurons in the brain. Such neurodegeneration is a crucial feature of aging as well as age-related neurological disorders. Therefore, understanding the processes leading to aging and associated neurological problems will help to develop the new therapeutic avenues. The cognitive processes during aging and age-associated neurological disorders are regulated by epigenetic modification...
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Papers by Meghraj Singh Baghel