The individual members of the Turkish Asthma Control Test (TACT) Study Group should have been lis... more The individual members of the Turkish Asthma Control Test (TACT) Study Group should have been listed as full co-authors in the original publication. All authors are listed in this erratum.
The novel coronavirus pandemic poses a major global threat to public health. Our knowledge concer... more The novel coronavirus pandemic poses a major global threat to public health. Our knowledge concerning every aspect of COVID-19 is evolving rapidly, given the increasing data from all over the world. In this narrative review, the Turkish Thoracic Society Early Career Taskforce members aimed to provide a summary on recent literature regarding epidemiology, clinical findings, diagnosis, treatment, prevention, and control of COVID-19. Studies revealed that the genetic sequence of the novel coronavirus showed significant identity to SARS-CoV and MERS-CoV. Angiotensin-converting enzyme 2 receptor is an important target of the SARS-CoV-2 while entering an organism. Smokers were more likely to develop the disease and have a higher risk for ICU admission. The mean incubation period was 6.4 days, whereas asymptomatic transmission was reported up to 25 days after infection. Fever and cough were the most common symptoms, and cardiovascular diseases and hypertension were reported to be the most ...
Summary Castleman's disease is a rare lymphoproliferative disorder, which usually occurs in ... more Summary Castleman's disease is a rare lymphoproliferative disorder, which usually occurs in the chest. The localized form, which is the most common, is often asymptomatic, but can cause nonspecific thoracic symptoms such as cough and dyspnea. Surgical removal is the ...
Introduction: The effects of pesticide application on the health of the individuals living in the... more Introduction: The effects of pesticide application on the health of the individuals living in the same environment should be considered as a public health problem.Objective: We aimed to compare respiratory complaints and respiratory functions of people living in agricultural areas, before and after pesticide application which cause air pollution. Materials and Methods: Two hundred and fifty two individuals (144 women, 108 men) living in Sanliurfa Province in Turkey (widespread cotton farming area) were asked about respiratory and systemic complaints, lung function tests were applied. After administration of pesticide, 66 individuals were examined. PM2.5 (μgr / m3) and PM10 (μgr / m3) were measured. Results: The mean values of PM2.5 (7.9 μg / m3 and 13.0 μg / m3, p Conclusion: Pesticide administration leads to decrease in respiratory function and increase in respiratory complaints of adults living in the area.
In the present study, we aimed to evaluate the morphological and functional characteristics in sy... more In the present study, we aimed to evaluate the morphological and functional characteristics in symptomatic and asymptomatic smokers in comparison to nonsmokers in order to gain better understanding of the pathogenesis and early diagnosis of Chronic Obstructive Pulmonary Disease (COPD). A Randomized, double-blind, placebo -controlled, parallel-group trial vas performed. A total of 50 male patients (40 smokers and 10 non-smokers) who completed a questionnaire, between the ages of 18-60 (mean age 32), were included the study. Of the smokers, 23 were symptomatic, and 17 were asymptomatic. High-resolution computerized tomography (HRCT) and pulmonary function tests (PFTs) were performed in all cases. In the evaluation of all smokers, a comparison of the PFTs and morphological changes revealed a significant correlation between all morphological parameters and ΔN2/l. Although a relationship was found between the smoking score and the closing volume (CV), ΔN2/l and anatomic dead space (ADS) ...
Background Denim sandblasting-induced silicosis is a recently identified occupational disease. Ai... more Background Denim sandblasting-induced silicosis is a recently identified occupational disease. Aims In this study, we aimed to evaluate pulmonary and radiological changes in the long-term follow-up of former denim sandblasters. Methods Ninety former denim sandblasters were followed from 2007 to 2018. Chest X-rays were evaluated according to the International Labour Organization (ILO) classification. Baseline and final data were compared. Silicosis prevalence, radiological progression and pulmonary dysfunction were evaluated. Results All of the sandblasters were men. Their mean age was 34 ± 5 years, mean follow-up time was 9 ± 2 years (mean time since initial exposure: 17 ± 2 years) and mean duration of exposure was 34 ± 25 months. Rates of radiological progression and decline in pulmonary during follow-up were 63% and 39%, respectively. During follow-up, all patients were diagnosed with silicosis. All workers who were ILO category 0 at baseline (n = 26, 29%) progressed to higher cat...
Background: Many laboratory parameters have been associated with morbidity and mortality in SARS-... more Background: Many laboratory parameters have been associated with morbidity and mortality in SARS-CoV-2 (COVID-19), which emerged in an animal market in Wuhan, China in December 2019 and has infected over 20 million people. This study investigated the relationship between serum interleukin (IL)-18, IL-1 receptor antagonist (IL-1Ra), and alpha defensin levels and the clinical course and prognosis of COVID-19. Materials and Methods: This study included 100 patients who were admitted to the chest diseases department and intensive care unit of our hospital and diagnosed with COVID-19 by real-time polymerase chain reaction (PCR) of nasopharyngeal swab samples between March 24 and May 31, 2020. The control group consisted of 50 nonsymptomatic health workers with negative real-time PCR results in routine COVID-19 screening in our hospital. Results: Serum alpha defensin, IL-1Ra, and IL-18 levels were significantly higher in patients who developed macrophage activation syndrome (MAS) and acute respiratory distress syndrome (ARDS) compared to patients who did not (p < .001 for all). Alpha defensin, IL-1Ra, and IL-18 levels were significantly higher in COVID-19 patients with and without MAS or ARDS when compared to the control group (p < .001 for all). When the 9 patients who died were compared with the 91 surviving patients, IL-1Ra and IL-18 levels were found to be significantly higher in the nonsurvivors (p < .001). Conclusion: Our findings of correlations between alpha defensin and levels of IL-1Ra and IL-18, which were previously shown to be useful in COVID-19 treatment and follow-up, indicates that it may also be promising in treatment.
Silica particles induce lung inflammation and fibrosis. Here we show that stimulator of interfero... more Silica particles induce lung inflammation and fibrosis. Here we show that stimulator of interferon genes (STING) is essential for silica-induced lung inflammation. In mice, silica induces lung cell death and self-dsDNA release in the bronchoalveolar space that activates STING pathway. Degradation of extracellular self-dsDNA by DNase I inhibits silica-induced STING activation and the downstream type I IFN response. Patients with silicosis have increased circulating dsDNA and CXCL10 in sputum, and patients with fibrotic interstitial lung disease display STING activation and CXCL10 in the lung. In vitro, while mitochondrial dsDNA is sensed by cGAS-STING in dendritic cells, in macrophages extracellular dsDNA activates STING independent of cGAS after silica exposure. These results reveal an essential function of STING-mediated self-dsDNA sensing after silica exposure, and identify DNase I as a potential therapy for silica-induced lung inflammation.
Cite this article as: Bayram M, Akgün M. If you know the enemy and your weapons, you need not fea... more Cite this article as: Bayram M, Akgün M. If you know the enemy and your weapons, you need not fear the management of chronic obstructive pulmonary disease.
Primary ciliary dyskinesia (PCD) is a chronic, inherited disease characterized by ciliary dysfunc... more Primary ciliary dyskinesia (PCD) is a chronic, inherited disease characterized by ciliary dysfunction leading to defects in mucociliary clearance, thus causing upper and lower respiratory problems such as sinusitis and bronchiectasis as well as infertility. Diagnostic workup includes a combination of different techniques such as nasal nitric oxide measurement, high-speed video microscopy analysis, electron microscopy, and genetic analysis because there is no single gold standard due to the genetic and phenotypic heterogeneity of the disease [1,2]. Due to the chronic nature of the disease, difficulty in expectorating respiratory secretions, chronic presence of symptoms such as productive cough, and requirement of daily treatment, this disease poses a burden on the patients and their families. PCD negatively impacts quality of life (QOL) because of disease complications as well as treatment burden. Moreover, treatment adherence decreases with time in patients, which might further deteriorate prognosis [3].
Denim sandblasting has recently been defined as a cause of silicosis. Silicosis a progressive fib... more Denim sandblasting has recently been defined as a cause of silicosis. Silicosis a progressive fibrotic lung disease and may develop or progress with time even after exposure to silica has stopped. However, there is no previous study showing the course of silicosis due to denim sandblasting among former denim sandblasters. We aimed to determine whether there was a radiological progression of diseases and new cases that fit diagnostic criteria of silicosis according to ILO classification among former denim sandblasters who were evaluated in 2007 and had no further exposure to silica dust during four year of follow-up period. Secondly, we aimed to investigate loss of pulmonary function and mortality rate among this population. We also aimed to determine whether there was an association between radiological progression, loss of pulmonary function and mortality and predetermined risk factors including exposure duration, seniority at work and number of workplace they worked. The study inc...
evaluation of treatment response in patients with non-resectable hepatic alveolar echinococcosis ... more evaluation of treatment response in patients with non-resectable hepatic alveolar echinococcosis using computed tomography via the Cavalieri method.
Snoring is a common complaint, especially among the elderly individuals. In the treatment of snor... more Snoring is a common complaint, especially among the elderly individuals. In the treatment of snoring, many options, surgical or nonsurgical, are available. In this randomized study, we used a modiWed technique including some components of radiofrequency-assisted uvulopalatoplasty (RAUP) and Uvulopalatopharyngoplasty UPPP (modiWed-RAUP, MRAUP) and RAUP in a control group. A total of 60 patients (58 male and 2 female), 30 in each group (MRAUP and RAUP groups), with an average age of 38 § 9 years were included in the study. In the MRAUP group, in addition to the modiWed surgery, preoperative steroid injection was used as a preemptive analgesic and preincisional steroid injection and closure of the edges of the incision were performed to achieve better relief of pain. Snoring score, pain at rest and during swallowing, analgesic consumption and speech score were evaluated using standard 10 cm visual analog scales (VAS). Operation time and other complications were recorded. The patients in the MRAUP group had better pain scores, both at rest and during swallowing, and less analgesic consumption. Although operation time was longer in the MRAUP group compared to that of the RAUP group, snoring score, evaluated from day 1 to the 6th month after operation, was signiWcantly better in the MRAUP group. Postoperative speech scores at each visit were similar in both groups. In the MRAUP group, 87% of the patients (26 patients) had a Wnal VAS for snoring below 3, while in the RAUP group 63% of the patients (19 patients) were below 3 on the scale (P < 0.05). Thus, MRAUP seems to be a promising technique for surgery as a treatment for snoring.
We aimed to assess whether there was a correlation between the apnea-hypopnea index (AHI), desatu... more We aimed to assess whether there was a correlation between the apnea-hypopnea index (AHI), desaturation time under 90% (DTU-90), and mean saturation (MS) levels and the parameters associated with tissue hypoxia. Materials and methods: A total of 144 subjects were included in the study. Blood C-reactive protein levels, blood uric acid levels, and urine microalbumin levels were measured and the urine uric acid/creatinine ratio and urine microalbumin/creatinine ratio were calculated. Results: Our study results suggest that MS and DTU-90, as well as the AHI, are correlated with the parameters reflecting hypoxemia and the other events secondary to hypoxia. Conclusion: MS and DTU-90 may reflect the severity of disease and may be used in the first evaluation of a patient with suspicion of obstructive sleep apnea before full polysomnography monitorization. Because they were not much better correlated with the parameters than the AHI, it is difficult to make a claim for their use as the only tool, or their replacement of the AHI, in the evaluation of patients with suspected obstructive sleep apnea.
coronavirus disease (COVID-19) spread rapidly around the world, with over 3 million confirmed cas... more coronavirus disease (COVID-19) spread rapidly around the world, with over 3 million confirmed cases by the end of April 2020. In the majority of infected patients, COVID-19 is either asymptomatic or presents with mild symptoms such as loss of taste and smell, sore throat, fatigue and joint pain. However, it can have a much more severe course in older people, patients with hypertension (HT), and conditions that can impair immunity such as diabetes mellitus (DM), HIV, long-term immunosuppressive therapy and pregnancy. 1 While many comorbidities have been associated with COVID-19 mortality, there are also laboratory diagnostic tests associated with early poor prognosis. Of these, the most frequently used parameters are D-dimer, ferritin, leukopenia, fibrinogen, prothrombin time and IL-6 level. These parameters alone are not effective in directing
Macrophage activation syndrome (MAS) is one of the main causes of morbidity and mortality in pati... more Macrophage activation syndrome (MAS) is one of the main causes of morbidity and mortality in patients with coronavirus disease 2019 (COVID-19). This study aimed to investigate the relationship between the pentraxin 3 (PTX3) gene polymorphisms rs2305619 (281A/G) and rs1840680 (1449A/G) and the development of MAS in patients with COVID-19. The study included a total of 94 patients aged 18-45 who were diagnosed as having COVID-19 between June and December 2020. PTX3 281A/G and 1449A/G polymorphism frequencies were evaluated. PTX3 281A/G allele and genotype frequencies did not deviate from Hardy-Weinberg (HW) equilibrium in the MAS or non-MAS group (χ 2 : 0.049, df: 2, p = 0.976, χ 2 : 0.430, df: 2, How to cite this article: Kerget F, Kerget B, Kahraman ÇY, et al. Evaluation of the relationship between pentraxin 3 (PTX3) rs2305619 (281A/G) and rs1840680 (1449A/G) polymorphisms and the clinical course of COVID-19.
The individual members of the Turkish Asthma Control Test (TACT) Study Group should have been lis... more The individual members of the Turkish Asthma Control Test (TACT) Study Group should have been listed as full co-authors in the original publication. All authors are listed in this erratum.
The novel coronavirus pandemic poses a major global threat to public health. Our knowledge concer... more The novel coronavirus pandemic poses a major global threat to public health. Our knowledge concerning every aspect of COVID-19 is evolving rapidly, given the increasing data from all over the world. In this narrative review, the Turkish Thoracic Society Early Career Taskforce members aimed to provide a summary on recent literature regarding epidemiology, clinical findings, diagnosis, treatment, prevention, and control of COVID-19. Studies revealed that the genetic sequence of the novel coronavirus showed significant identity to SARS-CoV and MERS-CoV. Angiotensin-converting enzyme 2 receptor is an important target of the SARS-CoV-2 while entering an organism. Smokers were more likely to develop the disease and have a higher risk for ICU admission. The mean incubation period was 6.4 days, whereas asymptomatic transmission was reported up to 25 days after infection. Fever and cough were the most common symptoms, and cardiovascular diseases and hypertension were reported to be the most ...
Summary Castleman's disease is a rare lymphoproliferative disorder, which usually occurs in ... more Summary Castleman's disease is a rare lymphoproliferative disorder, which usually occurs in the chest. The localized form, which is the most common, is often asymptomatic, but can cause nonspecific thoracic symptoms such as cough and dyspnea. Surgical removal is the ...
Introduction: The effects of pesticide application on the health of the individuals living in the... more Introduction: The effects of pesticide application on the health of the individuals living in the same environment should be considered as a public health problem.Objective: We aimed to compare respiratory complaints and respiratory functions of people living in agricultural areas, before and after pesticide application which cause air pollution. Materials and Methods: Two hundred and fifty two individuals (144 women, 108 men) living in Sanliurfa Province in Turkey (widespread cotton farming area) were asked about respiratory and systemic complaints, lung function tests were applied. After administration of pesticide, 66 individuals were examined. PM2.5 (μgr / m3) and PM10 (μgr / m3) were measured. Results: The mean values of PM2.5 (7.9 μg / m3 and 13.0 μg / m3, p Conclusion: Pesticide administration leads to decrease in respiratory function and increase in respiratory complaints of adults living in the area.
In the present study, we aimed to evaluate the morphological and functional characteristics in sy... more In the present study, we aimed to evaluate the morphological and functional characteristics in symptomatic and asymptomatic smokers in comparison to nonsmokers in order to gain better understanding of the pathogenesis and early diagnosis of Chronic Obstructive Pulmonary Disease (COPD). A Randomized, double-blind, placebo -controlled, parallel-group trial vas performed. A total of 50 male patients (40 smokers and 10 non-smokers) who completed a questionnaire, between the ages of 18-60 (mean age 32), were included the study. Of the smokers, 23 were symptomatic, and 17 were asymptomatic. High-resolution computerized tomography (HRCT) and pulmonary function tests (PFTs) were performed in all cases. In the evaluation of all smokers, a comparison of the PFTs and morphological changes revealed a significant correlation between all morphological parameters and ΔN2/l. Although a relationship was found between the smoking score and the closing volume (CV), ΔN2/l and anatomic dead space (ADS) ...
Background Denim sandblasting-induced silicosis is a recently identified occupational disease. Ai... more Background Denim sandblasting-induced silicosis is a recently identified occupational disease. Aims In this study, we aimed to evaluate pulmonary and radiological changes in the long-term follow-up of former denim sandblasters. Methods Ninety former denim sandblasters were followed from 2007 to 2018. Chest X-rays were evaluated according to the International Labour Organization (ILO) classification. Baseline and final data were compared. Silicosis prevalence, radiological progression and pulmonary dysfunction were evaluated. Results All of the sandblasters were men. Their mean age was 34 ± 5 years, mean follow-up time was 9 ± 2 years (mean time since initial exposure: 17 ± 2 years) and mean duration of exposure was 34 ± 25 months. Rates of radiological progression and decline in pulmonary during follow-up were 63% and 39%, respectively. During follow-up, all patients were diagnosed with silicosis. All workers who were ILO category 0 at baseline (n = 26, 29%) progressed to higher cat...
Background: Many laboratory parameters have been associated with morbidity and mortality in SARS-... more Background: Many laboratory parameters have been associated with morbidity and mortality in SARS-CoV-2 (COVID-19), which emerged in an animal market in Wuhan, China in December 2019 and has infected over 20 million people. This study investigated the relationship between serum interleukin (IL)-18, IL-1 receptor antagonist (IL-1Ra), and alpha defensin levels and the clinical course and prognosis of COVID-19. Materials and Methods: This study included 100 patients who were admitted to the chest diseases department and intensive care unit of our hospital and diagnosed with COVID-19 by real-time polymerase chain reaction (PCR) of nasopharyngeal swab samples between March 24 and May 31, 2020. The control group consisted of 50 nonsymptomatic health workers with negative real-time PCR results in routine COVID-19 screening in our hospital. Results: Serum alpha defensin, IL-1Ra, and IL-18 levels were significantly higher in patients who developed macrophage activation syndrome (MAS) and acute respiratory distress syndrome (ARDS) compared to patients who did not (p < .001 for all). Alpha defensin, IL-1Ra, and IL-18 levels were significantly higher in COVID-19 patients with and without MAS or ARDS when compared to the control group (p < .001 for all). When the 9 patients who died were compared with the 91 surviving patients, IL-1Ra and IL-18 levels were found to be significantly higher in the nonsurvivors (p < .001). Conclusion: Our findings of correlations between alpha defensin and levels of IL-1Ra and IL-18, which were previously shown to be useful in COVID-19 treatment and follow-up, indicates that it may also be promising in treatment.
Silica particles induce lung inflammation and fibrosis. Here we show that stimulator of interfero... more Silica particles induce lung inflammation and fibrosis. Here we show that stimulator of interferon genes (STING) is essential for silica-induced lung inflammation. In mice, silica induces lung cell death and self-dsDNA release in the bronchoalveolar space that activates STING pathway. Degradation of extracellular self-dsDNA by DNase I inhibits silica-induced STING activation and the downstream type I IFN response. Patients with silicosis have increased circulating dsDNA and CXCL10 in sputum, and patients with fibrotic interstitial lung disease display STING activation and CXCL10 in the lung. In vitro, while mitochondrial dsDNA is sensed by cGAS-STING in dendritic cells, in macrophages extracellular dsDNA activates STING independent of cGAS after silica exposure. These results reveal an essential function of STING-mediated self-dsDNA sensing after silica exposure, and identify DNase I as a potential therapy for silica-induced lung inflammation.
Cite this article as: Bayram M, Akgün M. If you know the enemy and your weapons, you need not fea... more Cite this article as: Bayram M, Akgün M. If you know the enemy and your weapons, you need not fear the management of chronic obstructive pulmonary disease.
Primary ciliary dyskinesia (PCD) is a chronic, inherited disease characterized by ciliary dysfunc... more Primary ciliary dyskinesia (PCD) is a chronic, inherited disease characterized by ciliary dysfunction leading to defects in mucociliary clearance, thus causing upper and lower respiratory problems such as sinusitis and bronchiectasis as well as infertility. Diagnostic workup includes a combination of different techniques such as nasal nitric oxide measurement, high-speed video microscopy analysis, electron microscopy, and genetic analysis because there is no single gold standard due to the genetic and phenotypic heterogeneity of the disease [1,2]. Due to the chronic nature of the disease, difficulty in expectorating respiratory secretions, chronic presence of symptoms such as productive cough, and requirement of daily treatment, this disease poses a burden on the patients and their families. PCD negatively impacts quality of life (QOL) because of disease complications as well as treatment burden. Moreover, treatment adherence decreases with time in patients, which might further deteriorate prognosis [3].
Denim sandblasting has recently been defined as a cause of silicosis. Silicosis a progressive fib... more Denim sandblasting has recently been defined as a cause of silicosis. Silicosis a progressive fibrotic lung disease and may develop or progress with time even after exposure to silica has stopped. However, there is no previous study showing the course of silicosis due to denim sandblasting among former denim sandblasters. We aimed to determine whether there was a radiological progression of diseases and new cases that fit diagnostic criteria of silicosis according to ILO classification among former denim sandblasters who were evaluated in 2007 and had no further exposure to silica dust during four year of follow-up period. Secondly, we aimed to investigate loss of pulmonary function and mortality rate among this population. We also aimed to determine whether there was an association between radiological progression, loss of pulmonary function and mortality and predetermined risk factors including exposure duration, seniority at work and number of workplace they worked. The study inc...
evaluation of treatment response in patients with non-resectable hepatic alveolar echinococcosis ... more evaluation of treatment response in patients with non-resectable hepatic alveolar echinococcosis using computed tomography via the Cavalieri method.
Snoring is a common complaint, especially among the elderly individuals. In the treatment of snor... more Snoring is a common complaint, especially among the elderly individuals. In the treatment of snoring, many options, surgical or nonsurgical, are available. In this randomized study, we used a modiWed technique including some components of radiofrequency-assisted uvulopalatoplasty (RAUP) and Uvulopalatopharyngoplasty UPPP (modiWed-RAUP, MRAUP) and RAUP in a control group. A total of 60 patients (58 male and 2 female), 30 in each group (MRAUP and RAUP groups), with an average age of 38 § 9 years were included in the study. In the MRAUP group, in addition to the modiWed surgery, preoperative steroid injection was used as a preemptive analgesic and preincisional steroid injection and closure of the edges of the incision were performed to achieve better relief of pain. Snoring score, pain at rest and during swallowing, analgesic consumption and speech score were evaluated using standard 10 cm visual analog scales (VAS). Operation time and other complications were recorded. The patients in the MRAUP group had better pain scores, both at rest and during swallowing, and less analgesic consumption. Although operation time was longer in the MRAUP group compared to that of the RAUP group, snoring score, evaluated from day 1 to the 6th month after operation, was signiWcantly better in the MRAUP group. Postoperative speech scores at each visit were similar in both groups. In the MRAUP group, 87% of the patients (26 patients) had a Wnal VAS for snoring below 3, while in the RAUP group 63% of the patients (19 patients) were below 3 on the scale (P < 0.05). Thus, MRAUP seems to be a promising technique for surgery as a treatment for snoring.
We aimed to assess whether there was a correlation between the apnea-hypopnea index (AHI), desatu... more We aimed to assess whether there was a correlation between the apnea-hypopnea index (AHI), desaturation time under 90% (DTU-90), and mean saturation (MS) levels and the parameters associated with tissue hypoxia. Materials and methods: A total of 144 subjects were included in the study. Blood C-reactive protein levels, blood uric acid levels, and urine microalbumin levels were measured and the urine uric acid/creatinine ratio and urine microalbumin/creatinine ratio were calculated. Results: Our study results suggest that MS and DTU-90, as well as the AHI, are correlated with the parameters reflecting hypoxemia and the other events secondary to hypoxia. Conclusion: MS and DTU-90 may reflect the severity of disease and may be used in the first evaluation of a patient with suspicion of obstructive sleep apnea before full polysomnography monitorization. Because they were not much better correlated with the parameters than the AHI, it is difficult to make a claim for their use as the only tool, or their replacement of the AHI, in the evaluation of patients with suspected obstructive sleep apnea.
coronavirus disease (COVID-19) spread rapidly around the world, with over 3 million confirmed cas... more coronavirus disease (COVID-19) spread rapidly around the world, with over 3 million confirmed cases by the end of April 2020. In the majority of infected patients, COVID-19 is either asymptomatic or presents with mild symptoms such as loss of taste and smell, sore throat, fatigue and joint pain. However, it can have a much more severe course in older people, patients with hypertension (HT), and conditions that can impair immunity such as diabetes mellitus (DM), HIV, long-term immunosuppressive therapy and pregnancy. 1 While many comorbidities have been associated with COVID-19 mortality, there are also laboratory diagnostic tests associated with early poor prognosis. Of these, the most frequently used parameters are D-dimer, ferritin, leukopenia, fibrinogen, prothrombin time and IL-6 level. These parameters alone are not effective in directing
Macrophage activation syndrome (MAS) is one of the main causes of morbidity and mortality in pati... more Macrophage activation syndrome (MAS) is one of the main causes of morbidity and mortality in patients with coronavirus disease 2019 (COVID-19). This study aimed to investigate the relationship between the pentraxin 3 (PTX3) gene polymorphisms rs2305619 (281A/G) and rs1840680 (1449A/G) and the development of MAS in patients with COVID-19. The study included a total of 94 patients aged 18-45 who were diagnosed as having COVID-19 between June and December 2020. PTX3 281A/G and 1449A/G polymorphism frequencies were evaluated. PTX3 281A/G allele and genotype frequencies did not deviate from Hardy-Weinberg (HW) equilibrium in the MAS or non-MAS group (χ 2 : 0.049, df: 2, p = 0.976, χ 2 : 0.430, df: 2, How to cite this article: Kerget F, Kerget B, Kahraman ÇY, et al. Evaluation of the relationship between pentraxin 3 (PTX3) rs2305619 (281A/G) and rs1840680 (1449A/G) polymorphisms and the clinical course of COVID-19.
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