Antibodies and Antibody Derivatives: New Partners in HIV Eradication Strategies (Q58572618)

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2 May 2020

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Antibodies and Antibody Derivatives: New Partners in HIV Eradication Strategies (English)

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human immunodeficiency virus infectious disease

2 May 2020

main subject

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Retroviridae infectious disease

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RNA virus infectious disease

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neutralizing antibody

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1

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2 May 2020

Julià Blanco

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Bonaventura Clotet Sala

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Bonaventura Clotet

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language of work or name

English

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publication date

23 October 2018

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Frontiers in Immunology

10 references

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27 November 2019

13 December 2019

28 April 2020

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Creative Commons Attribution 4.0 International

2 May 2020

copyright license

9 references

19 October 2019

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1 July 2020

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27 October 2020

19 January 2021

HIV-1 cell-to-cell transmission and broadly neutralizing antibodies

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cites work

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A single injection of crystallizable fragment domain-modified antibodies elicits durable protection from SHIV infection.

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Impact of intensification with raltegravir on HIV-1-infected individuals receiving monotherapy with boosted PIs.

30 November 2018

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Tackling HIV Persistence: Pharmacological versus CRISPR-Based Shock Strategies.

30 November 2018

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Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice.

30 November 2018

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Aging in HIV-Infected Subjects: A New Scenario and a New View

30 November 2018

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The role of latency reversal agents in the cure of hiv: A review of current data.

30 November 2018

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Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: A Phase 1 open-label clinical trial in healthy adults.

30 November 2018

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Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells.

30 November 2018

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Recent progress in immune-based interventions to prevent HIV-1 transmission to children

30 November 2018

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eCD4-Ig promotes ADCC activity of sera from HIV-1-infected patients

30 November 2018

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Basis and Statistical Design of the Passive HIV-1 Antibody Mediated Prevention (AMP) Test-of-Concept Efficacy Trials

30 November 2018

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The Neutralizing Antibody Response To the HIV-1 Env Protein.

30 November 2018

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HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study.

30 November 2018

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Memory B cell dysregulation in HIV-1-infected individuals.

30 November 2018

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Immunologic Insights on the Membrane Proximal External Region: A Major Human Immunodeficiency Virus Type-1 Vaccine Target.

30 November 2018

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Control of the HIV-1 DNA Reservoir Is Associated In Vivo and In Vitro with NKp46/NKp30 (CD335 CD337) Inducibility and Interferon Gamma Production by Transcriptionally Unique NK Cells

30 November 2018

1 reference

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The role of novel immunotherapies in non-Hodgkin lymphoma

30 November 2018

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Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

30 November 2018

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Landscape review of current HIV 'kick and kill' cure research - some kicking, not enough killing.

30 November 2018

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Potent In Vivo NK Cell-mediated Elimination of HIV-1-Infected Cells Mobilized by a gp120-bispecific and Hexavalent Broadly Neutralizing Fusion Protein.

30 November 2018

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Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latency

30 November 2018

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Early antibody therapy can induce long-lasting immunity to SHIV

30 November 2018

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Promise and problems associated with the use of recombinant AAV for the delivery of anti-HIV antibodies

30 November 2018

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HIV-Specific Granzyme B-Secreting but Not Gamma Interferon-Secreting T Cells Are Associated with Reduced Viral Reservoirs in Early HIV Infection.

30 November 2018

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Use of broadly neutralizing antibodies for HIV-1 prevention

30 November 2018

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Antibody 10-1074 suppresses viremia in HIV-1-infected individuals

30 November 2018

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Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.

30 November 2018

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Envelope-specific antibodies and antibody-derived molecules for treating and curing HIV infection

30 November 2018

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The Latent Reservoir for HIV-1: How Immunologic Memory and Clonal Expansion Contribute to HIV-1 Persistence

30 November 2018

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HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption

30 November 2018

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Engineered Bispecific Antibodies with Exquisite HIV-1-Neutralizing Activity

30 November 2018

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30 November 2018

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Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo

30 November 2018

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Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

30 November 2018

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A comprehensive review of the neonatal Fc receptor and its application in drug delivery.

30 November 2018

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Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques

30 November 2018

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Macrophages and HIV-1: An Unhealthy Constellation

30 November 2018

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Bryostatin-1 for latent virus reactivation in HIV-infected patients on antiretroviral therapy

30 November 2018

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Replication of Human Herpesviruses Is Associated with Higher HIV DNA Levels during Antiretroviral Therapy Started at Early Phases of HIV Infection.

30 November 2018

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Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection

30 November 2018

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Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study

30 November 2018

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Residual inflammation and viral reservoirs: alliance against an HIV cure

30 November 2018

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Immune correlates of vaccine protection against HIV-1 acquisition

30 November 2018

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Activation and lysis of human CD4 cells latently infected with HIV-1

30 November 2018

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Host Anti-antibody Responses Following Adeno-associated Virus-mediated Delivery of Antibodies Against HIV and SIV in Rhesus Monkeys

30 November 2018

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Antiviral Monoclonal Antibodies: Can They Be More Than Simple Neutralizing Agents?

30 November 2018

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Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial

30 November 2018

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Glycan modulation and sulfoengineering of anti-HIV-1 monoclonal antibody PG9 in plants.

30 November 2018

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Dual-Affinity Re-Targeting proteins direct T cell-mediated cytolysis of latently HIV-infected cells

30 November 2018

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The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo

30 November 2018

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Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults

30 November 2018

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Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.

30 November 2018

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HIV-1 gp120 as a therapeutic target: navigating a moving labyrinth

30 November 2018

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AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

30 November 2018

1 reference

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Vectored antibody gene delivery for the prevention or treatment of HIV infection

30 November 2018

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Understanding HIV latency: the road to an HIV cure

30 November 2018

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Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

30 November 2018

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In vitro and in vivo modifications of recombinant and human IgG antibodies

30 November 2018

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Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy

30 November 2018

1 reference

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Lessons from the RV144 Thai phase III HIV-1 vaccine trial and the search for correlates of protection

30 November 2018

1 reference

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Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity

30 November 2018

1 reference

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Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo

30 November 2018

1 reference

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Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice

30 November 2018

1 reference

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Enhanced neonatal Fc receptor function improves protection against primate SHIV infection

30 November 2018

1 reference

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Broadly neutralizing antibodies that inhibit HIV-1 cell to cell transmission

30 November 2018

1 reference

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Intensification of a raltegravir-based regimen with maraviroc in early HIV-1 infection

30 November 2018

1 reference

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Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys

30 November 2018

1 reference

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Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia

30 November 2018

1 reference

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Isolation of HIV-1-reactive antibodies using cell surface-expressed gp160Δc(BaL.).

30 November 2018

1 reference

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Early but limited effects of raltegravir intensification on CD4 T cell reconstitution in HIV-infected patients with an immunodiscordant response to antiretroviral therapy.

30 November 2018

1 reference

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Neutralizing antibodies to HIV-1 induced by immunization.

30 November 2018

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Attacking the HIV reservoir from the immune and viral perspective

30 November 2018

1 reference

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Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

30 November 2018

1 reference

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Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies

30 November 2018

1 reference

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HIV therapy by a combination of broadly neutralizing antibodies in humanized mice.

30 November 2018

1 reference

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Raltegravir intensification shows differing effects on CD8 and CD4 T cells in HIV-infected HAART-suppressed individuals with poor CD4 T-cell recovery

30 November 2018

1 reference

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Evasion from NK cell-mediated immune responses by HIV-1

30 November 2018

1 reference

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Cell-cell transmission enables HIV-1 to evade inhibition by potent CD4bs directed antibodies

30 November 2018

1 reference

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Isotype and glycoform selection for antibody therapeutics

30 November 2018

1 reference

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Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation

30 November 2018

1 reference

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Treatment intensification with raltegravir in subjects with sustained HIV-1 viraemia suppression: a randomized 48-week study.

30 November 2018

1 reference

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Increasing the potency and breadth of an HIV antibody by using structure-based rational design

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

Safety and efficacy of HIV hyperimmune globulin for prevention of mother-to-child HIV transmission in HIV-1-infected pregnant women and their infants in Kampala, Uganda (HIVIGLOB/NVP STUDY).

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

Fc-glycosylation influences Fcγ receptor binding and cell-mediated anti-HIV activity of monoclonal antibody 2G12.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

Antigp41 antibodies fail to block early events of virological synapses but inhibit HIV spread between T cells

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

Fc receptor but not complement binding is important in antibody protection against HIV.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

FcRn: the neonatal Fc receptor comes of age.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

Experimental approaches to the study of HIV-1 latency

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

Depletion of latent HIV-1 infection in vivo: a proof-of-concept study

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

Relationship between the size of the human immunodeficiency virus type 1 (HIV-1) reservoir in peripheral blood CD4+ T cells and CD4+:CD8+ T cell ratios in aviremic HIV-1-infected individuals receiving long-term highly active antiretroviral therapy

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

A phase I trial with two human monoclonal antibodies (hMAb 2F5, 2G12) against HIV-1.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

Reservoirs for HIV-1: mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

Persistence of HIV-1 Transcription in Peripheral-Blood Mononuclear Cells in Patients Receiving Potent Antiretroviral Therapy

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

Efficacy of zidovudine and human immunodeficiency virus (HIV) hyperimmune immunoglobulin for reducing perinatal HIV transmission from HIV-infected women with advanced disease: results of Pediatric AIDS Clinical Trials Group protocol 185.

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

IgG-Fc-mediated effector functions: molecular definition of interaction sites for effector ligands and the role of glycosylation

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

Safety and pharmacokinetics of hyperimmune anti-human immunodeficiency virus (HIV) immunoglobulin administered to HIV-infected pregnant women and their newborns. Pediatric AIDS Clinical Trials Group Protocol 185 Pharmacokinetic Study Group

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

Passive immunotherapy in the treatment of advanced human immunodeficiency virus infection

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1

30 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6205993

Passive immunization with the anti-HIV-1 human monoclonal antibody (hMAb) 4E10 and the hMAb combination 4E10/2F5/2G12

30 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/30405624

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

HIV infection results in clonal expansions containing integrations within pathogenesis-related biological pathways

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/30405624

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

1 reference

https://pubmed.ncbi.nlm.nih.gov/30405624

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3389/FIMMU.2018.02429

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30405624%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30405624%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

PubMed publication ID

30405624

1 reference