Loss of neurofibromin is associated with activation of RAS/MAPK and PI3-K/AKT signaling in a neurofibromatosis 1 astrocytoma. (Q55475127)

12 July 2018

title

Loss of neurofibromin is associated with activation of RAS/MAPK and PI3-K/AKT signaling in a neurofibromatosis 1 astrocytoma. (English)

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12 July 2018

author name string

Lau N

1

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12 July 2018

Feldkamp MM

2

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12 July 2018

Roncari L

3

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12 July 2018

Loehr AH

4

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12 July 2018

Shannon P

5

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12 July 2018

Gutmann DH

6

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12 July 2018

Guha A

7

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publication date

1 September 2000

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12 July 2018

Journal of Neuropathology & Experimental Neurology

published in

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12 July 2018

volume

59

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12 July 2018

issue

9

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12 July 2018

page(s)

759-767

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12 July 2018

cDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product

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AN UNIDENTIFIED VIRUS WHICH CAUSES THE RAPID PRODUCTION OF TUMOURS IN MICE.

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Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop.

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Proliferation of human malignant astrocytomas is dependent on Ras activation

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Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders

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The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2.

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Expression of activated epidermal growth factor receptors, Ras-guanosine triphosphate, and mitogen-activated protein kinase in human glioblastoma multiforme specimens

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Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis

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21 January 2018

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Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis

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Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells

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21 January 2018

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

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Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

21 January 2018

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Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation

21 January 2018

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Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/JNEN/59.9.759

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12 July 2018

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12 July 2018