Caveolin-1 inhibits cell detachment-induced p53 activation and anoikis by upregulation of insulin-like growth factor-I receptors and signaling. (Q40481718)

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English	Caveolin-1 inhibits cell detachment-induced p53 activation and anoikis by upregulation of insulin-like growth factor-I receptors and signaling.	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Caveolin-1 inhibits cell detachment-induced p53 activation and anoikis by upregulation of insulin-like growth factor-I receptors and signaling. (English)

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

author name string

Dana Ravid

1

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Sharon Maor

2

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Haim Werner

3

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Mordechai Liscovitch

4

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Europe PubMed Central

PubMed publication ID

20 September 2017

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publication date

1 February 2005

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

24

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

1338-1347

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

The IGF‐1 receptor in cancer biology

1 reference

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A system for stable expression of short interfering RNAs in mammalian cells

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Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation

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Role of caveolin and caveolae in insulin signaling and diabetes

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Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue

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Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice

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Mitogenic signaling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase.

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CEACAM6 cross-linking induces caveolin-1-dependent, Src-mediated focal adhesion kinase phosphorylation in BxPC3 pancreatic adenocarcinoma cells

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Reciprocal regulation of neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo. Implications for human breast cancer

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Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth

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Genes encoding human caveolin-1 and -2 are co-localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers

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Human caveolin-1 and caveolin-2 are closely linked genes colocalized with WI-5336 in a region of 7q31 frequently deleted in tumors

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Cellular tumorigenicity in nude mice: correlation with cell growth in semi-solid medium.

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Disruption of epithelial cell-matrix interactions induces apoptosis

1 reference

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21 January 2018

Anoikis mechanisms

1 reference

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21 January 2018

Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade

1 reference

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Expression of caveolin-1 and -2 in differentiating PC12 cells and dorsal root ganglion neurons: caveolin-2 is up-regulated in response to cell injury

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Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

1 reference

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Molecular mechanisms of "detachment-induced apoptosis--Anoikis".

1 reference

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21 January 2018

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

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Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis

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A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain

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Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

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Reduction of caveolin and caveolae in oncogenically transformed cells

1 reference

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Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A.

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Multiple functions of caveolin-1.

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The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells

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Targeting the PI3K-Akt pathway in human cancer: rationale and promise

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Loss of Matrix Adhesion Triggers Rapid Transformation-Selective Apoptosis in Fibroblasts

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Essential role of caveolae in interleukin-6- and insulin-like growth factor I-triggered Akt-1-mediated survival of multiple myeloma cells

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Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor

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Caveolin-1, a putative tumour suppressor gene

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7 January 2021

based on heuristic

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Caveolae: from cell biology to animal physiology

1 reference

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21 January 2018

Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles

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Expression of an IGF-I receptor dominant negative mutant induces apoptosis, inhibits tumorigenesis and enhances chemosensitivity in Ewing's sarcoma cells.

1 reference

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Caspase-8 activation and bid cleavage contribute to MCF7 cellular execution in a caspase-3-dependent manner during staurosporine-mediated apoptosis

1 reference

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Caveolin-1 is regulated by c-myc and suppresses c-myc-induced apoptosis

1 reference

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21 January 2018

Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts

1 reference

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Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice

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The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways.

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21 January 2018

Caveolin is an activator of insulin receptor signaling

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Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs

1 reference

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Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide

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Caveolin-1 inhibits anchorage-independent growth, anoikis and invasiveness in MCF-7 human breast cancer cells

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Up-regulation of caveolae and caveolar constituents in multidrug-resistant cancer cells

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Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells

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The role of the insulin-like growth factor system in human cancer

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Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities

1 reference

24 May 2022

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Identifiers

10.1038/SJ.ONC.1208337

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

ResearchGate publication ID

0 references

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