Oxidative stress in Alzheimer's disease: Primary villain or physiological by-product? (Q38121221)

PubMed publication ID

23849337

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23849337%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

Oxidative stress in Alzheimer's disease: Primary villain or physiological by-product? (English)

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12 May 2020

0 references

1

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12 May 2020

Paul K Witting

series ordinal

4

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12 May 2020

author name string

Belal Chami

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6837641&resulttype=core&format=json

12 May 2020

Priscilla Youssef

series ordinal

3

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12 May 2020

publication date

1 January 2013

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PubMed publication ID

23849337

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23849337%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

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12 May 2020

volume

18

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12 May 2020

issue

4

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12 May 2020

page(s)

134-141

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

12 May 2020

cites work

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Alzheimer's disease pathologic cascades: who comes first, what drives what

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Neuropathological stageing of Alzheimer-related changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Trafficking and proteolytic processing of APP

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Intracellular amyloid-beta in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Alzheimer's disease: the amyloid cascade hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Alzheimer's disease: synaptic dysfunction and Abeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Alzheimer's disease: redox dysregulation as a common denominator for diverse pathogenic mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

NO signaling in the CNS: from the physiological to the pathological

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Metal dyshomeostasis and oxidative stress in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Alzheimer neuropathologic alterations in aged cognitively normal subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Frequency of Stages of Alzheimer-Related Lesions in Different Age Categories

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Reduced mitochondrial coupling in vivo alters cellular energetics in aged mouse skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Extracellular redox state: refining the definition of oxidative stress in aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

The mitochondrial theory of aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse-prone 8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Free radical-mediated oxidation of free amino acids and amino acid residues in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Oxidative stress hypothesis in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Role of oxidative stress in the progression of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

RNA damage and surveillance under oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Lipid peroxidation and neurodegenerative disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Oxidative stress and amyloid-beta pathology in normal individuals with a maternal history of Alzheimer's

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Alzheimer's amyloid beta-peptide (1-42): involvement of methionine residue 35 in the oxidative stress and neurotoxicity properties of this peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Amyloid-β peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Nitric oxide signaling in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Mitochondrial β-amyloid in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Redox-active iron mediates amyloid-beta toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Iron, zinc and copper in the Alzheimer's disease brain: A quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Detection and localization of markers of oxidative stress by in situ methods: application in the study of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Free heme toxicity and its detoxification systems in human

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Copper promotes the trafficking of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Physiological and pathological aspects of Abeta in iron homeostasis via 5'UTR in the APP mRNA and the therapeutic use of iron-chelators

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

The cerebrocortical areas in normal brain aging and in Alzheimer's disease: noticeable differences in the lipid peroxidation level and in antioxidant defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Oxidative stress in the progression of Alzheimer disease in the frontal cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Impact of gender on upregulation of antioxidant defence mechanisms in Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Lipid peroxidation and antioxidant enzyme activities in vascular and Alzheimer dementias.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Regional brain activity of free radical defense enzymes in autopsy samples from patients with Alzheimer's disease and from nondemented controls

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Superoxide dismutase SOD1, encoded on chromosome 21, but not SOD2 is overexpressed in brains of patients with Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Amyloid beta-peptide (1-40)-mediated oxidative stress in cultured hippocampal neurons. Protein carbonyl formation, CK BB expression, and the level of Cu, Zn, and Mn SOD mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Oxidative damage is the earliest event in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Neuronal RNA oxidation in Alzheimer's disease and Down's syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Comparison of clinical characteristics between familial and non-familial early onset Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

NADPH oxidases: novel therapeutic targets for neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Amyloid-β: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-β

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2F1351000213Y.0000000052

Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin

21 January 2018

1 reference

12 December 2020

Metal protein attenuating compounds for the treatment of Alzheimer's disease

1 reference

12 December 2020

The pathological process underlying Alzheimer's disease in individuals under thirty

1 reference

12 December 2020

Vitamin E for Alzheimer's dementia and mild cognitive impairment

1 reference

12 December 2020

Oxidative damage to RNA in neurodegenerative diseases

1 reference

12 December 2020

Is there a neuropathology difference between mild cognitive impairment and dementia?

1 reference

12 December 2020

The brain in Down syndrome

1 reference

12 December 2020

Alzheimer's disease and antioxidant therapy: how long how far?

1 reference

12 December 2020

A critical review of vitamin C for the prevention of age-related cognitive decline and Alzheimer's disease

1 reference

12 December 2020

Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

1 reference

12 December 2020

Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease.

1 reference

12 December 2020

Selenium and Alzheimer's Disease: A Systematic Review

1 reference

12 December 2020

Increased Expression but Reduced Activity of Antioxidant Enzymes in Alzheimer's Disease

1 reference

12 December 2020

Evidence of neuronal oxidative damage in Alzheimer's disease.

1 reference

12 December 2020

Localization of manganese superoxide dismutase in the cerebral cortex and hippocampus of Alzheimer-type senile dementia

1 reference

12 December 2020

Metal protein attenuating compounds for the treatment of Alzheimer's dementia

1 reference

12 December 2020

10.1179/1351000213Y.0000000052

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6837641&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6837641&resulttype=core&format=json

12 May 2020

PubMed publication ID

23849337

1 reference