Clinical Implication of p53 Mutation in Lung Cancer (Q35127312)

6 August 2017

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title

Clinical implication of p53 mutation in lung cancer (English)

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6 August 2017

Clinical Implication of p53 Mutation in Lung Cancer (English)

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Applied Microbiology and Biotechnology

2 January 2024

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2 January 2024

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2 January 2024

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2 January 2024

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2 January 2024

2

Wafik S. El-Deiry

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12746555

2 January 2024

author name string

Barbara G. Campling

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12746555

2 January 2024

language of work or name

English

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12746555

2 January 2024

publication date

1 June 2003

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full work available at URL

6 August 2017

http://www.springerlink.com/index/pdf/10.1385/MB:24:2:141

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2 January 2024

published in

Molecular Biotechnology

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6 August 2017

volume

24

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6 August 2017

issue

2

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6 August 2017

page(s)

141-156

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Allele-specific loss in chromosome 9p loci in preneoplastic lesions accompanying non-small-cell lung cancers

6 August 2017

cites work

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12 December 2020

Comparative analysis of p53 gene mutations and protein accumulation in human non-small-cell lung cancer

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Analysis of p53 antibodies in patients with various cancers define B-cell epitopes of human p53: distribution on primary structure and exposure on protein surface

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Use of the single strand conformation polymorphism technique and PCR to detect p53 gene mutations in small cell lung cancer

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Prognostic significance of serum p53 antibodies in squamous cell carcinoma of the lung

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Increased expression of mutant forms of p53 oncogene in primary lung cancer

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Correlation of abnormal RB, p16ink4a, and p53 expression with 3p loss of heterozygosity, other genetic abnormalities, and clinical features in 103 primary non-small cell lung cancers

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Nuclear p53 overexpression is an independent prognostic parameter in node-negative non-small cell lung carcinoma

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Lung carcinoma in former smokers

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Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering.

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12 December 2020

p53 antibodies in the sera of lung cancer patients: comparison with p53 mutation in the tumour tissue

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12 December 2020

Prognostic value of serum p53 antibodies in patients with resected non-small cell lung cancer

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12 December 2020

p53 protein in non-small cell lung cancer as quantitated by enzyme-linked immunosorbent assay: relation to prognosis

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12 December 2020

Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.

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12 December 2020

p53 mutations in defined structural and functional domains are related to poor clinical outcome in non-small cell lung cancer patients

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12 December 2020

Serum anti-p53 autoantibodies in primary resected non-small-cell lung carcinoma

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12 December 2020

Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse

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12 December 2020

A specific spectrum of p53 mutations in lung cancer from smokers: review of mutations compiled in the IARC p53 database

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Anti-p53 antibodies in sera from patients with chronic obstructive pulmonary disease can predate a diagnosis of cancer.

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The p53 tumour suppressor gene

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12 December 2020

p53 expression in normal and dysplastic bronchial epithelium and in lung carcinomas

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12 December 2020

Prognostic significance of abnormal p53 accumulation in primary, resected non-small-cell lung cancers

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12 December 2020

Thymocyte apoptosis induced by p53-dependent and independent pathways.

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12 December 2020

Aberrant p53 expression predicts clinical resistance to cisplatin-based chemotherapy in locally advanced non-small cell lung cancer

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12 December 2020

The utility of p53 immunostaining of transbronchial biopsy specimens of lung cancer: p53 overexpression predicts poor prognosis and chemoresistance in advanced non-small cell lung cancer

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12 December 2020

Accumulation of p53 protein as a possible predictor of response to adjuvant combination chemotherapy with cyclophosphamide, methotrexate, fluorouracil, and prednisone for breast cancer

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12 December 2020

p53 mutations increase resistance to ionizing radiation

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12 December 2020

The p53 gene is very frequently mutated in small-cell lung cancer with a distinct nucleotide substitution pattern

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12 December 2020

Rapid p53 sequence analysis in primary lung cancer using an oligonucleotide probe array

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12 December 2020

Detection of antibodies against the cellular protein p53 in sera from patients with breast cancer

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12 December 2020

Immunohistochemical detection of p53 in non-small-cell lung cancer

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12 December 2020

A comparative study of p53 gene mutations, protein accumulation, and response to cisplatin-based chemotherapy in advanced ovarian carcinoma

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12 December 2020

p53 Mutation and MDM2 amplification in human soft tissue sarcomas

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12 December 2020

Mutations of the p53 Gene as a Predictor of Poor Prognosis in Patients With Non-Small-Cell Lung Cancer

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12 December 2020

Altered retinoblastoma and p53 protein status in non-small cell carcinoma of the lung: potential synergistic effects on prognosis

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12 December 2020

ATM: a mediator of multiple responses to genotoxic stress

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12 December 2020

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.

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12 December 2020

Clinical implications of the p53 tumor-suppressor gene

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12 December 2020

High frequency of somatically acquired p53 mutations in small-cell lung cancer cell lines and tumors

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12 December 2020

p53 protein accumulates frequently in early bronchial neoplasia.

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12 December 2020

p53 in non-small-cell lung cancer.

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12 December 2020

Accumulation of p53 protein correlates with a poor prognosis in human lung cancer

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12 December 2020

Bcl-2 protein: a prognostic factor inversely correlated to p53 in non-small-cell lung cancer

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12 December 2020

p53 mutations and exposure to environmental tobacco smoke in a multicenter study on lung cancer.

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12 December 2020

Molecular pathologic substaging in 244 stage I non-small-cell lung cancer patients: clinical implications

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12 December 2020

A biologic risk model for stage I lung cancer: immunohistochemical analysis of 408 patients with the use of ten molecular markers

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12 December 2020

Prevalence of serum antibodies against the p53 tumor suppressor gene protein in various cancers

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12 December 2020

p53 is required for radiation-induced apoptosis in mouse thymocytes

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12 December 2020

Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer

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12 December 2020

Prognostic significance of p53 and ras gene abnormalities in lung adenocarcinoma patients with stage I disease after curative resection.

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12 December 2020

p53 immunostaining positivity is associated with reduced survival and is imperfectly correlated with gene mutations in resected non-small cell lung cancer. A preliminary report of LCSG 871

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12 December 2020

Effective treatment of early endobronchial cancer with regional administration of liposome-p53 complexes

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12 December 2020

p53 and chemosensitivity

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12 December 2020

P53 auto-antibodies in non-small cell lung cancer patients can predict increased life expectancy after radiotherapy

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12 December 2020

Tumor surveillance via the ARF-p53 pathway.

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12 December 2020

Predictive survival markers in patients with surgically resected non-small cell lung carcinoma

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12 December 2020

Aberrations of the p53 tumor suppressor gene in human non-small cell carcinomas of the lung

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12 December 2020

Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome?

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12 December 2020

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12 December 2020

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

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12 December 2020

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

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12 December 2020

Wild-type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesions

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12 December 2020

IARC p53 mutation database: a relational database to compile and analyze p53 mutations in human tumors and cell lines. International Agency for Research on Cancer

1 reference

12 December 2020

p53 exon 5 mutations as a prognostic indicator of shortened survival in non-small-cell lung cancer

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12 December 2020

Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer

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12 December 2020

p53 mutations in non-small-cell lung cancers occurring in individuals without a past history of active smoking

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12 December 2020

Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small-cell lung carcinoma

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12 December 2020

Prognostic significance of p53 and ras p21 expression in nonsmall cell lung cancer

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12 December 2020

Measurement and evaluation of serum anti-p53 antibody levels in patients with lung cancer at its initial presentation: a prospective study

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12 December 2020

Frequent TP53 gene alterations (mutation, allelic loss, nuclear accumulation) in primary non-small cell lung cancer

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12 December 2020

A dose-response relationship between the frequency of p53 mutations and tobacco consumption in lung cancer patients

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12 December 2020

Clonal genetic alterations in the lungs of current and former smokers

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12 December 2020

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

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12 December 2020

K-ras mutations are a relatively late event in the pathogenesis of lung carcinomas

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12 December 2020

Screening patients for heterozygous p53 mutations using a functional assay in yeast

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12 December 2020

Relationship of p53 overexpression and up-regulation of proliferating cell nuclear antigen with the clinical course of non-small cell lung cancer

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12 December 2020

Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers

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12 December 2020

Targeting of lung cancer mutational hotspots by polycyclic aromatic hydrocarbons

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12 December 2020

The prognostic significance of accumulation of p53 protein in stage III non-small cell lung cancer treated by radiotherapy

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12 December 2020

p53: a frequent target for genetic abnormalities in lung cancer.

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12 December 2020

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

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12 December 2020

p21 expression as a predictor for favorable prognosis in squamous cell carcinoma of the lung

1 reference

12 December 2020

Prognostic significance of p53 protein expression and DNA ploidy in surgically treated non-small cell lung carcinomas

1 reference

12 December 2020

The TP53 genotype but not immunohistochemical result is predictive of response to cisplatin-based neoadjuvant therapy in stage III non-small cell lung cancer

1 reference

12 December 2020

Expression of p53 oncoprotein in non-small-cell lung cancer: a favorable prognostic factor

1 reference

12 December 2020

bcl-2 and p53 protein expression in non-small cell lung cancers: correlation with survival time.

1 reference

12 December 2020

Immunohistochemical study of p53 in human lung carcinomas.

1 reference

12 December 2020

Serum Anti-p53 Antibodies and Prognosis of Patients With Small-Cell Lung Cancer

1 reference

12 December 2020

Development of antibodies against p53 in lung cancer patients appears to be dependent on the type of p53 mutation

1 reference

12 December 2020

Molecular Damage in the Bronchial Epithelium of Current and Former Smokers

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12 December 2020

Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene

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12 December 2020

Apoptotic death of tumor cells correlates with chemosensitivity, independent of p53 or bcl-2

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12 December 2020

p53 mutations in non-small cell lung cancer in Japan: association between mutations and smoking

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12 December 2020

The relationship of p53 immunostaining to survival in carcinoma of the lung

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12 December 2020

p53 mutations do not predict response to paclitaxel in metastatic nonsmall cell lung carcinoma

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12 December 2020

Serum p53 antibodies as early markers of lung cancer

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12 December 2020

Tumors associated with p53 germline mutations: a synopsis of 91 families.

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12 December 2020

Correlations between intrinsic chemoresistance and HER-2/neu gene expression, p53 gene mutations, and cell proliferation characteristics in non-small cell lung cancer cell lines

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12 December 2020

Presence of serum anti-p53 antibodies is associated with pleural effusion and poor prognosis in lung cancer patients

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12 December 2020

Analyses of p53 antibodies in sera of patients with lung carcinoma define immunodominant regions in the p53 protein

1 reference

12 December 2020

Association between cigarette smoking and mutation of the p53 gene in squamous-cell carcinoma of the head and neck

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12 December 2020

p53 Antibodies in the sera of patients with various types of cancer: a review

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12 December 2020

Gender differences in p53 mutational status in small cell lung cancer

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12 December 2020

A prognostic model of recurrence and death in stage I non-small cell lung cancer utilizing presentation, histopathology, and oncoprotein expression.

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12 December 2020

Mutations in exon 7 and 8 of p53 as poor prognostic factors in patients with non-small cell lung cancer

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12 December 2020

p53 mutations predict non-small cell lung carcinoma response to radiotherapy

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12 December 2020

Recurrence and death in non-small cell lung carcinomas: a prognostic model using pathological parameters, microvessel count, and gene protein products.

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12 December 2020

Germ-line p53 mutations predispose to a wide spectrum of early-onset cancers.

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12 December 2020

Clinical implications of p53 autoantibodies in the sera of patients with non-small-cell lung cancer

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12 December 2020

Detection of oncogene mutations in sputum precedes diagnosis of lung cancer.

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12 December 2020

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

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12 December 2020

Immunocytochemical markers in stage I lung cancer: relevance to prognosis

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12 December 2020

Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma

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12 December 2020

Cell suicide for beginners

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12 December 2020

K-ras and p53 mutations are an independent unfavourable prognostic indicator in patients with non-small-cell lung cancer

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12 December 2020

Surfing the p53 network

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12 December 2020

Alcohol consumption and cigarette smoking increase the frequency of p53 mutations in non-small cell lung cancer

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12 December 2020

p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features

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12 December 2020

Vascular endothelial growth factor, wild-type p53, and angiogenesis in early operable non-small cell lung cancer

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12 December 2020

High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints

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12 December 2020

Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation

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12 December 2020

Prognostic significance of p53 mutations and 3p deletions in primary resected non-small cell lung cancer

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12 December 2020

Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.

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12 December 2020

p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents

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12 December 2020

Identifiers

DOI

10.1385/MB:24:2:141

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Dimensions Publication ID

6 August 2017

1013696485

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Fatcat ID

release_mbjd3mdiknhpfczh3ty5xacwva

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Fatcat

https://api.fatcat.wiki/v0/release/mbjd3mdiknhpfczh3ty5xacwva

24 November 2022

mapped directly with Wikidata item

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