Glucosylceramide synthase, a factor in modulating drug resistance, is overexpressed in metastatic breast carcinoma (Q33683147)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21617856%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

title

Glucosylceramide synthase, a factor in modulating drug resistance, is overexpressed in metastatic breast carcinoma (English)

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2 February 2020

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1

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2 February 2020

author name string

Gauri A Patwardhan

2

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2 February 2020

Ping Xie

3

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2 February 2020

Xin Gu

4

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2 February 2020

Armando E Giuliano

5

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2 February 2020

Myles C Cabot

6

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2 February 2020

publication date

23 May 2011

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International Journal of Oncology

2 February 2020

published in

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2 February 2020

volume

39

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2 February 2020

issue

2

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2 February 2020

page(s)

425-431

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Suppression of Glucosylceramide Synthase Restores p53-Dependent Apoptosis in Mutant p53 Cancer Cells

2 February 2020

cites work

1 reference

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Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling

21 June 2018

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Direct assessment of P-glycoprotein efflux to determine tumor response to chemotherapy.

21 June 2018

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Assessment of an RNA interference screen-derived mitotic and ceramide pathway metagene as a predictor of response to neoadjuvant paclitaxel for primary triple-negative breast cancer: a retrospective analysis of five clinical trials

21 June 2018

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Anthracycline- and/or taxane-resistant breast cancer: results of a literature review to determine the clinical challenges and current treatment trends

21 June 2018

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A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis

21 June 2018

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Co-suppression of MDR1 (multidrug resistance 1) and GCS (glucosylceramide synthase) restores sensitivity to multidrug resistance breast cancer cells by RNA interference (RNAi).

21 June 2018

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VEGF recruits lactosylceramide to induce endothelial cell adhesion molecule expression and angiogenesis in vitro and in vivo

21 June 2018

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A role for ceramide in driving cancer cell resistance to doxorubicin.

21 June 2018

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Principles of bioactive lipid signalling: lessons from sphingolipids

21 June 2018

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Overview of resistance to systemic therapy in patients with breast cancer

21 June 2018

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Overexpression of glucosylceramide synthase in associated with multidrug resistance of leukemia cells

21 June 2018

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Modulation of multidrug resistance efflux pump activity to overcome chemoresistance in cancer

21 June 2018

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The glycosphingolipid globotriaosylceramide in the metastatic transformation of colon cancer

21 June 2018

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Biologically active sphingolipids in cancer pathogenesis and treatment

21 June 2018

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Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy.

21 June 2018

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Sphingolipid metabolism enzymes as targets for anticancer therapy

21 June 2018

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Ceramide synthesis and metabolism as a target for cancer therapy.

21 June 2018

1 reference

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Radiation and ceramide-induced apoptosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4037863

Possible role of ceramide as an indicator of chemoresistance: decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia

21 June 2018

1 reference

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Molecular and pharmacological strategies to overcome multidrug resistance

21 June 2018

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Updates on functions of ceramide in chemotherapy-induced cell death and in multidrug resistance

21 June 2018

1 reference

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Multidrug resistance in cancer: role of ATP-dependent transporters

21 June 2018

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Role of ceramide in mediating the inhibition of telomerase activity in A549 human lung adenocarcinoma cells

21 June 2018

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Targeting ceramide metabolism--a strategy for overcoming drug resistance

21 June 2018

1 reference

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Glycosylation of ceramide potentiates cellular resistance to tumor necrosis factor-alpha-induced apoptosis

21 June 2018

1 reference

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Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells

21 June 2018

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Ganglioside GD1alpha functions in the adhesion of metastatic tumor cells to endothelial cells of the target tissue.

21 June 2018

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Accumulation of glucosylceramides in multidrug-resistant cancer cells

21 June 2018

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The sphingomyelin cycle and the second messenger function of ceramide.

21 June 2018

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P-glycoprotein, multidrug resistance and tumor progression

21 June 2018

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Glucosylceramide is synthesized at the cytosolic surface of various Golgi subfractions

21 June 2018

1 reference

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Prognostic relevance of glucosylceramide synthase (GCS) expression in breast cancer

21 June 2018

1 reference

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Microarray gene-expression profiling to predict lymph node metastasis in penile carcinoma.

30 October 2018

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A CERTain role for ceramide in taxane-induced cell death.

30 October 2018

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Ceramide glycosylation potentiates cellular multidrug resistance

30 October 2018

1 reference

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Gene signatures of progression and metastasis in renal cell cancer

30 October 2018

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12 December 2020

Up-regulation of glucosylceramide synthase in urinary bladder neoplasms

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12 December 2020

Apoptosis and cancer chemotherapy

1 reference

12 December 2020

Glucosylceramide: a marker for multiple-drug resistant cancers

1 reference

12 December 2020

Ceramide and apoptosis

1 reference

12 December 2020

Identifiers

DOI

10.3892/IJO.2011.1052

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21617856%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21617856%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

PubMed publication ID

21617856

1 reference