Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer (Q29616379)

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20 December 2019

review article

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title

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer (English)

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20 December 2019

author name string

Peter M Siegel

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1

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30 April 2017

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1 November 2003

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20 December 2019

published in

Nature Reviews Cancer

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volume

3

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20 December 2019

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11

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20 December 2019

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807-821

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Mechanisms of TGF-beta signaling from cell membrane to the nucleus

20 December 2019

cites work

1 reference

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

31 March 2020

1 reference

Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus

31 March 2020

1 reference

A distinct nuclear localization signal in the N terminus of Smad 3 determines its ligand-induced nuclear translocation

31 March 2020

1 reference

Formation of a stable heterodimer between Smad2 and Smad4

31 March 2020

1 reference

Crystal Structure of a Phosphorylated Smad2

31 March 2020

1 reference

Stoichiometry of active smad-transcription factor complexes on DNA

31 March 2020

1 reference

A transcriptional partner for MAD proteins in TGF-beta signalling

31 March 2020

1 reference

OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways

31 March 2020

1 reference

Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta

31 March 2020

1 reference

A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells.

31 March 2020

1 reference

Transcriptional control by the TGF-beta/Smad signaling system

31 March 2020

1 reference

E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

31 March 2020

1 reference

Regulation of cell proliferation by Smad proteins

31 March 2020

1 reference

Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity

31 March 2020

1 reference

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

31 March 2020

1 reference

Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7

31 March 2020

1 reference

Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

31 March 2020

1 reference

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

31 March 2020

1 reference

Ubiquitin-dependent degradation of TGF-beta-activated smad2.

31 March 2020

1 reference

Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription

31 March 2020

1 reference

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

31 March 2020

1 reference

TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses

31 March 2020

1 reference

Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses

31 March 2020

1 reference

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

31 March 2020

1 reference

Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

31 March 2020

1 reference

Smad-dependent GADD45beta expression mediates delayed activation of p38 MAP kinase by TGF-beta

31 March 2020

1 reference

TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest

31 March 2020

1 reference

Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

31 March 2020

1 reference

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

31 March 2020

1 reference

Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells

31 March 2020

1 reference

Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways

31 March 2020

1 reference

Oncogenic ras represses transforming growth factor-beta /Smad signaling by degrading tumor suppressor Smad4.

31 March 2020

1 reference

Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1

31 March 2020

1 reference

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

31 March 2020

1 reference

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

31 March 2020

1 reference

Concerted action of TGF-beta 1 and its type II receptor in control of epidermal homeostasis in transgenic mice

31 March 2020

1 reference

Development of gene-switch transgenic mice that inducibly express transforming growth factor beta1 in the epidermis

31 March 2020

1 reference

Conditional epidermal expression of TGFbeta 1 blocks neonatal lethality but causes a reversible hyperplasia and alopecia

31 March 2020

1 reference

TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis

31 March 2020

1 reference

Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice

31 March 2020

1 reference

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro

31 March 2020

1 reference

Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane

31 March 2020

1 reference

Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis

31 March 2020

1 reference

Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors

31 March 2020

1 reference

Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated

31 March 2020

1 reference

Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression

31 March 2020

1 reference

Transforming growth factor beta and cyclosporin A inhibit the inducible activity of the interleukin-2 gene in T cells through a noncanonical octamer-binding site

31 March 2020

1 reference

Transforming growth factor-beta promotes 'death by neglect' in post-activated human T cells

31 March 2020

1 reference

Transforming growth factor-beta in T-cell biology

31 March 2020

1 reference

Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells

31 March 2020

1 reference

Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation

31 March 2020

1 reference

Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4.

31 March 2020

1 reference

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism

31 March 2020

1 reference

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta

31 March 2020

1 reference

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

31 March 2020

1 reference

Repression of p15INK4b expression by Myc through association with Miz-1

31 March 2020

1 reference

TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

31 March 2020

1 reference

Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

31 March 2020

1 reference

Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta

31 March 2020

1 reference

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

31 March 2020

1 reference

The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2

31 March 2020

1 reference

Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins

31 March 2020

1 reference

Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-beta-mediated epithelial cell growth suppression.

31 March 2020

1 reference

Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells

31 March 2020

1 reference

TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinase

31 March 2020

1 reference

Activin/TGF-beta induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP.

31 March 2020

1 reference

Transforming growth factor-beta 1 suppresses serum deprivation-induced death of A549 cells through differential effects on c-Jun and JNK activities

31 March 2020

1 reference

Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1

31 March 2020

1 reference

A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif

31 March 2020

1 reference

TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation

31 March 2020

1 reference

Mechanisms of TGF-beta-mediated apoptosis

31 March 2020

1 reference

TGF-beta signaling in tumor suppression and cancer progression

31 March 2020

1 reference

TGFbeta signaling in growth control, cancer, and heritable disorders

31 March 2020

1 reference

TGF-beta signaling: positive and negative effects on tumorigenesis

31 March 2020

1 reference

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

31 March 2020

1 reference

Microsatellite instability and mutated type II transforming growth factor-beta receptor gene in gliomas.

31 March 2020

1 reference

Analyses of microsatellite instability and the transforming growth factor-beta receptor type II gene mutation in sporadic breast cancer and their correlation with clinicopathological features

31 March 2020

1 reference

Gene mutation of transforming growth factor beta1 type II receptor in hepatocellular carcinoma

31 March 2020

1 reference

TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice

31 March 2020

1 reference

Mammary tumor suppression by transforming growth factor beta 1 transgene expression

31 March 2020

1 reference

Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis

31 March 2020

1 reference

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

31 March 2020

1 reference

Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis

31 March 2020

1 reference

Mutations in the SMAD4/DPC4 gene in juvenile polyposis

31 March 2020

1 reference

Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice.

31 March 2020

1 reference

Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

31 March 2020

1 reference

Serrated adenomas and mixed polyposis caused by a splice acceptor deletion in the mouse Smad4 gene

31 March 2020

1 reference

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

31 March 2020

1 reference

Smad3 mutant mice develop metastatic colorectal cancer

31 March 2020

1 reference

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

31 March 2020

1 reference

Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction

31 March 2020

1 reference

Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases.

31 March 2020

1 reference

Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects

31 March 2020

1 reference

TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis

31 March 2020

1 reference

TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development

31 March 2020

1 reference

A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance

31 March 2020

1 reference

Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells

31 March 2020

1 reference

Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype

31 March 2020

1 reference

The Smad3 Protein Is Involved in TGF- Inhibition of Class II Transactivator and Class II MHC Expression

31 March 2020

1 reference

Immunoregulatory role of transforming growth factor beta (TGF-beta) in development of killer cells: comparison of active and latent TGF-beta 1

31 March 2020

1 reference

Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer

31 March 2020

1 reference

Regulation of the proinflammatory effects of Fas ligand (CD95L).

31 March 2020

1 reference

Expression of growth factors, growth-inhibiting factors, and their receptors in invasive breast cancer. II: Correlations with proliferation and angiogenesis

31 March 2020

1 reference

Transforming growth factor-beta1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma

31 March 2020

1 reference

Extracellular domain of TGFbeta type III receptor inhibits angiogenesis and tumor growth in human cancer cells

31 March 2020

1 reference

Involvement of CTGF, a hypertrophic chondrocyte-specific gene product, in tumor angiogenesis

31 March 2020

1 reference

A multigenic program mediating breast cancer metastasis to bone

31 March 2020

1 reference

Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia

31 March 2020

1 reference

TGFbeta2 and TGFbeta3 have separate and sequential activities during epithelial-mesenchymal cell transformation in the embryonic heart.

31 March 2020

1 reference

Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction

31 March 2020

1 reference

Transforming growth factor-beta 3 is required for secondary palate fusion

31 March 2020

1 reference

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells

31 March 2020

1 reference

TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors

31 March 2020

1 reference

Metastasis is driven by sequential elevation of H-ras and Smad2 levels.

31 March 2020

1 reference

Epithelial-mesenchymal transitions in tumour progression

31 March 2020

1 reference

The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion

31 March 2020

1 reference

Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.

31 March 2020

1 reference

The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition

31 March 2020

1 reference

Slug is an essential target of TGFbeta2 signaling in the developing chicken heart.

31 March 2020

1 reference

Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program

31 March 2020

1 reference

Targeting the TGF beta signaling network in human neoplasia

31 March 2020

1 reference

Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542

31 March 2020

1 reference

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

31 March 2020

1 reference

Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1.

31 March 2020

1 reference

Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation.

31 March 2020

1 reference

Overexpression of a kinase-deficient transforming growth factor-beta type II receptor in mouse mammary stroma results in increased epithelial branching

31 March 2020

1 reference

Expression of a dominant-negative type II transforming growth factor beta (TGF-beta) receptor in the epidermis of transgenic mice blocks TGF-beta-mediated growth inhibition

31 March 2020

1 reference

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

31 March 2020

1 reference

TGF-beta1 effects on proliferation of rat intestinal epithelial cells are due to inhibition of cyclin D1 expression

31 March 2020

1 reference

Transforming growth factor-beta mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells

31 March 2020

1 reference

Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas

31 March 2020

1 reference

Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions

31 March 2020

1 reference

The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice.

31 March 2020

1 reference

Effect of transforming growth factor-beta 1 on proliferation and death of rat prostatic cells

31 March 2020

1 reference

Absence of proximal duct apoptosis in the ventral prostate of transgenic mice carrying the C3(1)-TGF-beta type II dominant negative receptor.

31 March 2020

1 reference

Inhibition of capillary morphogenesis and associated apoptosis by dominant negative mutant transforming growth factor-beta receptors.

31 March 2020

1 reference

Transforming growth factor-beta1 induces apoptosis in vascular endothelial cells by activation of mitogen-activated protein kinase

31 March 2020

1 reference

Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable

31 March 2020

1 reference

Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease

31 March 2020

1 reference

Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor beta II receptor

31 March 2020

1 reference

Blockade of transforming growth factor beta/Smad signaling in T cells by overexpression of Smad7 enhances antigen-induced airway inflammation and airway reactivity

31 March 2020

1 reference

Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines

31 March 2020

1 reference

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20 December 2019

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