Pak to the future (Q28142927)

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

Europe PubMed Central

title

Pak to the future (English)

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author name string

S Bagrodia

series ordinal

1

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R A Cerione

series ordinal

2

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language of work or name

English

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publication date

September 1999

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published in

Trends in Cell Biology

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volume

9

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issue

9

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page(s)

350-5

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cites work

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Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways

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PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

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Pheromone signalling and polarized morphogenesis in yeast

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A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.

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Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation

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Genetic evidence for Pak1 autoinhibition and its release by Cdc42.

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Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A.

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PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

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Does Vav bind to F‐actin through a CH domain?

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A novel regulator of p21-activated kinases

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alphaPix stimulates p21-activated kinase activity through exchange factor-dependent and -independent mechanisms

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beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein

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Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling

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ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src.

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Identification of a new Pyk2 target protein with Arf-GAP activity

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7 January 2021

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

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Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck.

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A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids.

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Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2

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Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity

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Caspase-mediated activation of PAK2 during apoptosis: proteolytic kinase activation as a general mechanism of apoptotic signal transduction?

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7 January 2021

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

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7 January 2021

Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade

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RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase

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Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

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Membrane targeting of p21-activated kinase 1(PAK1) induces neurite outgrowth from PC12 cells

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7 January 2021

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

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Molecular mechanisms of nonmuscle myosin-II regulation

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Kinases, myosin phosphatase and Rho proteins: curiouser and curiouser

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Activation of Rac and Cdc42 by integrins mediates cell spreading

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Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (gamma-PAK)

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7 January 2021

Inhibition of myosin light chain kinase by p21-activated kinase

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7 January 2021

Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)

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Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

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7 January 2021

p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts

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7 January 2021

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

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7 January 2021

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

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Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation

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7 January 2021

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

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Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway

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RAS and RAF-1 form a signalling complex with MEK-1 but not MEK-2.

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A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function

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7 January 2021

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

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7 January 2021

The complexity of Raf-1 regulation

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Phosphorylation of Raf-1 Serine 338-Serine 339 Is an Essential Regulatory Event for Ras-Dependent Activation and Biological Signaling

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7 January 2021

Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms

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7 January 2021

Kinase-Deficient Pak1 Mutants Inhibit Ras Transformation of Rat-1 Fibroblasts

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7 January 2021

A role for Pak protein kinases in Schwann cell transformation

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7 January 2021

A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK

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7 January 2021

PAK3 mutation in nonsyndromic X-linked mental retardation

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7 January 2021

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7 January 2021