FoxL2 and Smad3 coordinately regulate follistatin gene transcription (Q24655444)

2

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Nicholas J Justice

3

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Wylie W Vale

4

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Wolfgang H Fischer

5

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Louise M Bilezikjian

Journal of Biological Chemistry

6

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language of work or name

English

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publication date

20 March 2009

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published in

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volume

284

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issue

12

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page(s)

7631-45

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cites work

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Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium

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Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function

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The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome

7 April 2017

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Multistep signaling requirements for pituitary organogenesis in vivo

7 April 2017

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Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes

7 April 2017

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Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

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Follistatin suppresses the production of experimental multiple-organ metastasis by small cell lung cancer cells in natural killer cell-depleted SCID mice

7 April 2017

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A Smad-binding element in intron 1 participates in activin-dependent regulation of the follistatin gene

7 April 2017

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Biological activity of follistatin isoforms and follistatin-like-3 is dependent on differential cell surface binding and specificity for activin, myostatin, and bone morphogenetic proteins

7 April 2017

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The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance

7 April 2017

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The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein

7 April 2017

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Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search

7 April 2017

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Signal transduction by the TGF-beta superfamily

7 April 2017

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Spectrum of FOXL2 gene mutations in blepharophimosis-ptosis-epicanthus inversus (BPES) families demonstrates a genotype--phenotype correlation

7 April 2017

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Follistatin: a multifunctional regulatory protein

7 April 2017

1 reference

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Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2

7 April 2017

1 reference

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Smad4 and FAST-1 in the assembly of activin-responsive factor

7 April 2017

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Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development

7 April 2017

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The role of FAST-1 and Smads in transcriptional regulation by activin during early Xenopus embryogenesis

7 April 2017

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Follistatin gene expression in the ovary and extragonadal tissues

7 April 2017

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Specificity and versatility in tgf-beta signaling through Smads

7 April 2017

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Forkhead transcription factors: key players in development and metabolism

7 April 2017

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Proteomic analysis of conditioned media from the PC3, LNCaP, and 22Rv1 prostate cancer cell lines: discovery and validation of candidate prostate cancer biomarkers

7 April 2017

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FOXL2 in the pituitary: molecular, genetic, and developmental analysis

28 September 2017

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Foxl2 function in ovarian development.

28 September 2017

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Antagonists of activin signaling: mechanisms and potential biological applications

28 September 2017

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Regulation of gonadotropin subunit gene transcription

28 September 2017

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Autocrine/paracrine regulation of pituitary function by activin, inhibin and follistatin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658057

Recognition of phosphorylated-Smad2-containing complexes by a novel Smad interaction motif

28 September 2017

1 reference

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Rat anterior pituitary folliculostellate cells are targets of interleukin-1beta and a major source of intrapituitary follistatin

28 September 2017

1 reference

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GnRH pulse frequency modulation of gonadotropin subunit gene transcription in normal gonadotropes-assessment by primary transcript assay provides evidence for roles of GnRH and follistatin

28 September 2017

1 reference

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Roles of activin and its signal transduction mechanisms in reproductive tissues

28 September 2017

1 reference

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Pituitary activin receptor subtypes and follistatin gene expression in female rats: differential regulation by activin and follistatin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658057

Primary structure of the human follistatin precursor and its genomic organization

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658057

Structural characterization of follistatin: a novel follicle-stimulating hormone release-inhibiting polypeptide from the gonad

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658057

Follistatin binds to both activin and inhibin through the common subunit

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658057

Follistatin gene expression in the pituitary: localization in gonadotropes and folliculostellate cells in diestrous rats

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658057

Multiple defects and perinatal death in mice deficient in follistatin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658057

Overexpression of mouse follistatin causes reproductive defects in transgenic mice.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658057

Expression and Localization of Activin Subunits and Follistatins in Tissues from Men with High Grade Prostate Cancer

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658057

Increased follistatin (activin-binding protein) gene expression in rat anterior pituitary tissue after ovariectomy may be mediated by pituitary activin

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658057

Molecular heterogeneity of follistatin, an activin-binding protein. Higher affinity of the carboxyl-terminal truncated forms for heparan sulfate proteoglycans on the ovarian granulosa cell

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658057

Activin-binding protein from rat ovary is follistatin

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658057

Evidence for an autocrine role of activin B within rat anterior pituitary cultures

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658057

Activin-binding protein is present in pituitary

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658057

Immunohistochemical Localization of Follistatin in Rat Tissues

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658057

Intracellular Responses to Gonadotropin-Releasing Hormone in a Clonal Cell Line of the Gonadotrope Lineage

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658057

Regulation of steady-state follistatin mRNA levels in rat granulosa cells in vitro

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658057

Identification of 34 novel and 56 known FOXL2 mutations in patients with Blepharophimosis syndrome.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658057

Differential functional effects of novel mutations of the transcription factor FOXL2 in BPES patients

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658057

Design and cloning of lentiviral vectors expressing small interfering RNAs

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658057

Probability-based evaluation of peptide and protein identifications from tandem mass spectrometry and SEQUEST analysis: the human proteome

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658057

Forkhead l2 is expressed in the ovary and represses the promoter activity of the steroidogenic acute regulatory gene

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658057

Evidence That Pituitary Adenylate Cyclase Activating Polypeptide Suppresses Follicle-Stimulating Hormone-β Messenger Ribonucleic Acid Levels by Stimulating Follistatin Gene Transcription1

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658057

Activin-A regulates follistatin secretion from cultured rat anterior pituitary cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2658057

Activin effects on neoplastic proliferation of human pituitary tumors

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19106105

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The isolation of polypeptides with FSH suppressing activity from bovine follicular fluid which are structurally different to inhibin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19106105

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Gonadotropin-releasing hormone regulates follicle-stimulating hormone-beta gene expression through an activin/follistatin autocrine or paracrine loop

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19106105