Nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 (Q21987765)

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mammalian protein found in Mus musculus
  • nuclear factor of activated T-cells, cytoplasmic 2
  • T-cell transcription factor NFAT1
  • NFAT pre-existing subunit
  • NF-ATp
  • Nfatc2
edit
Language Label Description Also known as
English
Nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
mammalian protein found in Mus musculus
  • nuclear factor of activated T-cells, cytoplasmic 2
  • T-cell transcription factor NFAT1
  • NFAT pre-existing subunit
  • NF-ATp
  • Nfatc2

Statements

molecular function
RNA polymerase II cis-regulatory region sequence-specific DNA binding
determination method or standard
IDA
5 references
retrieved
21 June 2018
stated in
NFATc2-mediated repression of cyclin-dependent kinase 4 expression
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60591&geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
21 June 2018
stated in
Nuclear factor of activated T cells (NFAT) is involved in the depolarization-induced activation of growth hormone-releasing hormone gene transcription in vitro
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60591&geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
21 June 2018
stated in
Isolation of the cyclosporin-sensitive T cell transcription factor NFATp
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60591&geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
21 June 2018
stated in
Identification and characterization of a novel nuclear factor of activated T-cells-1 isoform expressed in mouse brain
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60591&geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
21 June 2018
stated in
Sequential involvement of NFAT and Egr transcription factors in FasL regulation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60591&geneProductId=UniProtKB:Q60591
determination method or standard
IDA
protein binding
determination method or standard
IPI
5 references
retrieved
14 February 2019
stated in
Lysine 313 of T-box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T-bet
GOA
curator
UniProt
UniProt protein ID
Q60591
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IPI
retrieved
14 February 2019
stated in
NFAT Binding and Regulation of T Cell Activation by the Cytoplasmic Scaffolding Homer Proteins
GOA
curator
UniProt
UniProt protein ID
Q60591
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IPI
retrieved
14 February 2019
stated in
The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation
GOA
curator
UniProt
UniProt protein ID
Q60591
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IPI
retrieved
14 February 2019
stated in
An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2
GOA
curator
UniProt
UniProt protein ID
Q60591
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IPI
retrieved
14 February 2019
stated in
Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IPI
RNA polymerase II cis-regulatory region sequence-specific DNA binding
determination method or standard
IBA
IDA
5 references
retrieved
14 February 2019
stated in
NFATc2-mediated repression of cyclin-dependent kinase 4 expression
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
14 February 2019
stated in
Sequential involvement of NFAT and Egr transcription factors in FasL regulation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
14 February 2019
stated in
Isolation of the cyclosporin-sensitive T cell transcription factor NFATp
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
14 February 2019
stated in
Nuclear factor of activated T cells (NFAT) is involved in the depolarization-induced activation of growth hormone-releasing hormone gene transcription in vitro
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IBA
cell component
cytoplasm
determination method or standard
IDA
IEA
ISO
8 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q60591
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IEA
retrieved
14 February 2019
stated in
Defective T cell development and function in calcineurin A beta -deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
14 February 2019
stated in
Nuclear factor of activated T cells (NFAT) is involved in the depolarization-induced activation of growth hormone-releasing hormone gene transcription in vitro
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
14 February 2019
stated in
Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
14 February 2019
stated in
Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
14 February 2019
stated in
Dynamic response diversity of NFAT isoforms in individual living cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IDA
nucleus
determination method or standard
IDA
IEA
ISO
11 references
retrieved
21 June 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60591&geneProductId=UniProtKB:Q60591
determination method or standard
ISO
retrieved
21 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q60591
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60591&geneProductId=UniProtKB:Q60591
determination method or standard
IEA
retrieved
21 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60591&geneProductId=UniProtKB:Q60591
determination method or standard
IEA
retrieved
21 June 2018
stated in
An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2
GOA
curator
UniProt
UniProt protein ID
Q60591
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60591&geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
21 June 2018
stated in
Impairment of endothelial-mesenchymal transformation during atrioventricular cushion formation in Tmem100 null embryos
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60591&geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
21 June 2018
stated in
Calcium/NFAT signalling promotes early nephrogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60591&geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
21 June 2018
stated in
Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60591&geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
21 June 2018
stated in
The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60591&geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
21 June 2018
stated in
Isolation of the cyclosporin-sensitive T cell transcription factor NFATp
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60591&geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
21 June 2018
stated in
Nuclear factor of activated T cells (NFAT) is involved in the depolarization-induced activation of growth hormone-releasing hormone gene transcription in vitro
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60591&geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
21 June 2018
stated in
Dynamic response diversity of NFAT isoforms in individual living cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60591&geneProductId=UniProtKB:Q60591
determination method or standard
IDA
nucleus
determination method or standard
IBA
IDA
IEA
ISO
12 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q60591
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IEA
retrieved
14 February 2019
stated in
An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2
GOA
curator
UniProt
UniProt protein ID
Q60591
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
14 February 2019
stated in
Calcium/NFAT signalling promotes early nephrogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
14 February 2019
stated in
Nuclear factor of activated T cells (NFAT) is involved in the depolarization-induced activation of growth hormone-releasing hormone gene transcription in vitro
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
14 February 2019
stated in
Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
14 February 2019
stated in
Isolation of the cyclosporin-sensitive T cell transcription factor NFATp
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
14 February 2019
stated in
Dynamic response diversity of NFAT isoforms in individual living cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
14 February 2019
stated in
The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
14 February 2019
stated in
Impairment of endothelial-mesenchymal transformation during atrioventricular cushion formation in Tmem100 null embryos
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IBA
cytosol
determination method or standard
IBA
IDA
IEA
ISO
TAS
6 references
retrieved
14 February 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
TAS
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
ISO
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IEA
retrieved
14 February 2019
stated in
Isolation of the cyclosporin-sensitive T cell transcription factor NFATp
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
14 February 2019
stated in
Normal function of the transcription factor NFAT1 in wasted mice. Chromosome localization of NFAT1 gene
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IBA
biological process
positive regulation of transcription by RNA polymerase II
determination method or standard
IDA
IGI
7 references
retrieved
21 June 2018
stated in
A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60591&geneProductId=UniProtKB:Q60591
determination method or standard
IGI
retrieved
21 June 2018
stated in
Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60591&geneProductId=UniProtKB:Q60591
determination method or standard
IGI
retrieved
21 June 2018
stated in
Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60591&geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
21 June 2018
stated in
Nuclear factor of activated T cells (NFAT) is involved in the depolarization-induced activation of growth hormone-releasing hormone gene transcription in vitro
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60591&geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
21 June 2018
stated in
Isolation of the cyclosporin-sensitive T cell transcription factor NFATp
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60591&geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
21 June 2018
stated in
Identification and characterization of a novel nuclear factor of activated T-cells-1 isoform expressed in mouse brain
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60591&geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
21 June 2018
stated in
Sequential involvement of NFAT and Egr transcription factors in FasL regulation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60591&geneProductId=UniProtKB:Q60591
determination method or standard
IDA
positive regulation of transcription by RNA polymerase II
determination method or standard
IBA
IDA
IGI
6 references
retrieved
14 February 2019
stated in
A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IGI
retrieved
14 February 2019
stated in
Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IGI
retrieved
14 February 2019
stated in
Sequential involvement of NFAT and Egr transcription factors in FasL regulation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
14 February 2019
stated in
Isolation of the cyclosporin-sensitive T cell transcription factor NFATp
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
14 February 2019
stated in
Nuclear factor of activated T cells (NFAT) is involved in the depolarization-induced activation of growth hormone-releasing hormone gene transcription in vitro
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60591
determination method or standard
IBA

Identifiers

RefSeq protein ID
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21987765&oldid=2023401310"