ADAM metallopeptidase domain 10 (Q21113783)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14672

disintegrin domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14672

Metallopeptidase, catalytic domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14672

ADAMTS/ADAMTS-like

1 reference

Transporter Classification Database ID

8.A.77.1.4

2 October 2019

hierarchical database ID heuristic

Peptidase M12B, ADAM/reprolysin, protein family

1 reference

ADAM10/ADAM17 catalytic domain, protein family

1 reference

Disintegrin domain, protein family

1 reference

Peptidase M12B, propeptide family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

1 reference

9 May 2019

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

1 reference

9 May 2019

integrin binding

1 reference

9 May 2019

Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

peptidase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

1 reference

9 May 2019

protein binding

5 references

9 May 2019

Astroprincin (FAM171A1, C10orf38): A regulator of human cell shape and invasive growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

signaling receptor binding

1 reference

9 May 2019

MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

1 reference

9 May 2019

metallopeptidase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

6 references

9 May 2019

9 May 2019

Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

metalloendopeptidase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14672&geneProductId=UniProtKB:O14672

5 references

1 January 2018

1 January 2018

Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14672&geneProductId=UniProtKB:O14672

1 January 2018

Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14672&geneProductId=UniProtKB:O14672

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14672&geneProductId=UniProtKB:O14672

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14672&geneProductId=UniProtKB:O14672

metalloendopeptidase activity

Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

endopeptidase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

4 references

9 May 2019

ISS

9 May 2019

TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

cell component

postsynaptic density

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

focal adhesion

1 reference

9 May 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O14672

perinuclear endoplasmic reticulum

1 reference

9 May 2019

TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

Golgi-associated vesicle

1 reference

9 May 2019

ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

tetraspanin-enriched microdomain

1 reference

9 May 2019

The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

extracellular exosome

1 reference

9 May 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O14672

cell surface

3 references

9 May 2017

TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O14672

9 May 2017

ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O14672

9 May 2017

The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O14672

Golgi membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

1 reference

9 May 2019

extracellular space

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O14672

specific granule membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

1 reference

9 May 2019

tertiary granule membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

1 reference

9 May 2019

endoplasmic reticulum lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

1 reference

9 May 2019

trans-Golgi network

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

focal adhesion

1 reference

9 May 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

synaptic vesicle

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

cell surface

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

3 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

dendrite

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

soma

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

dendritic spine

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

postsynaptic membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

extracellular exosome

1 reference

9 May 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

postsynapse

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

glutamatergic synapse

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

biological process

Notch signaling pathway

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O14672

5 references

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O14672

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O14672

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O14672

9 May 2017

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O14672

positive regulation of cell migration

1 reference

9 May 2019

The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

ephrin receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O14672

1 reference

9 May 2017

cell-cell signaling

1 reference

9 May 2019

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

constitutive protein ectodomain proteolysis

1 reference

9 May 2019

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

protein processing

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

extracellular matrix disassembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

1 reference

9 May 2019

monocyte activation

1 reference

9 May 2019

Involvement of ADAM9 in multinucleated giant cell formation of blood monocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

response to tumor necrosis factor

1 reference

9 May 2019

Involvement of ADAM9 in multinucleated giant cell formation of blood monocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

positive regulation of cell growth

1 reference

9 May 2019

The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

positive regulation of T cell chemotaxis

1 reference

9 May 2019

The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

positive regulation of cell population proliferation

1 reference

9 May 2019

The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

Notch receptor processing

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=O14672

1 reference

9 May 2017

integrin-mediated signaling pathway

1 reference

9 May 2019

Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

membrane protein ectodomain proteolysis

TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant

14 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

ADAM10 releases a soluble form of the GPNMB/Osteoactivin extracellular domain with angiogenic properties

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

Calcium-regulated intramembrane proteolysis of the RAGE receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

Tumor-associated MICA is shed by ADAM proteases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

negative regulation of cell adhesion

2 references

neutrophil degranulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

1 reference

9 May 2019

post-translational protein modification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

1 reference

9 May 2019

Notch signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

spermatogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

amyloid-beta formation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

Notch receptor processing, ligand-dependent

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

1 reference

9 May 2019

positive regulation of apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

regulation of dendritic spine morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

response to antineoplastic agent

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

postsynapse organization

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14672

D08.811.277.656.675.374.102.250

Identifiers

MeSH descriptor ID

D000072197

subject named as

ADAM10 Protein

0 references

MeSH tree code

0 references

0 references

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

14 November 2015

http://www.uniprot.org/uniprot/O14672.txt?version=161

Transporter Classification Database ID

8.A.77.1.4

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023