Activating transcription factor 4 (Q21102119)

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mammalian protein found in Homo sapiens
  • tax-responsive enhancer element B67
  • cAMP-dependent transcription factor ATF-4
  • DNA-binding protein TAXREB67
  • cyclic AMP-responsive element-binding protein 2
  • cAMP response element-binding protein 2
  • CREB-2
  • cAMP-responsive element-binding protein 2
  • cyclic AMP-dependent transcription factor ATF-4
  • tax-responsive enhancer element-binding protein 67
  • ATF4
  • TaxREB67
edit
Language Label Description Also known as
English
Activating transcription factor 4
mammalian protein found in Homo sapiens
  • tax-responsive enhancer element B67
  • cAMP-dependent transcription factor ATF-4
  • DNA-binding protein TAXREB67
  • cyclic AMP-responsive element-binding protein 2
  • cAMP response element-binding protein 2
  • CREB-2
  • cAMP-responsive element-binding protein 2
  • cyclic AMP-dependent transcription factor ATF-4
  • tax-responsive enhancer element-binding protein 67
  • ATF4
  • TaxREB67

Statements

molecular function
protein binding
determination method or standard
IPI
26 references
retrieved
3 January 2017
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q96AQ3
determination method or standard
IPI
retrieved
3 January 2017
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q96AQ3
determination method or standard
IPI
retrieved
8 April 2019
stated in
C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene
GOA
curator
UniProt
UniProt protein ID
P18848
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IPI
retrieved
8 April 2019
stated in
SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia
GOA
curator
UniProt
UniProt protein ID
P18848
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mitosin/CENP-F as a negative regulator of activating transcription factor-4
GOA
curator
UniProt
UniProt protein ID
P18848
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IPI
retrieved
8 April 2019
stated in
A human protein-protein interaction network: a resource for annotating the proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IPI
retrieved
8 April 2019
stated in
DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IPI
retrieved
8 April 2019
stated in
ZIP kinase, a novel serine/threonine kinase which mediates apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IPI
retrieved
8 April 2019
stated in
New modularity of DAP-kinases: alternative splicing of the DRP-1 gene produces a ZIPk-like isoform
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IPI
retrieved
8 April 2019
stated in
Involvement of Nrf2 in proteasome inhibition-mediated induction of ORP150 in thyroid cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IPI
retrieved
8 April 2019
stated in
ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IPI
retrieved
8 April 2019
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IPI
retrieved
8 April 2019
stated in
A human MAP kinase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IPI
retrieved
8 April 2019
stated in
Functional interaction of the subunit 3 of RNA polymerase II (RPB3) with transcription factor-4 (ATF4)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IPI
retrieved
8 April 2019
stated in
Construction and characterization of a normalized yeast two-hybrid library derived from a human protein-coding clone collection
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IPI
retrieved
8 April 2019
stated in
Cooperative interaction of Zhangfei and ATF4 in transactivation of the cyclic AMP response element
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IPI
retrieved
8 April 2019
stated in
ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IPI
retrieved
8 April 2019
stated in
SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IPI
retrieved
8 April 2019
stated in
Shifted Transversal Design smart-pooling for high coverage interactome mapping
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IPI
retrieved
8 April 2019
stated in
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IPI
retrieved
8 April 2019
stated in
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IPI
DNA-binding transcription factor activity, RNA polymerase II-specific
determination method or standard
IC
IDA
ISA
ISM
NAS
6 references
retrieved
5 June 2018
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
determination method or standard
NAS
retrieved
5 June 2018
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
determination method or standard
ISM
retrieved
5 June 2018
stated in
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
determination method or standard
ISA
retrieved
5 June 2018
stated in
Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
determination method or standard
IDA
retrieved
5 June 2018
stated in
The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP)
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
determination method or standard
IDA
retrieved
5 June 2018
stated in
Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
determination method or standard
IC
DNA-binding transcription factor activity, RNA polymerase II-specific
determination method or standard
IBA
IDA
IEA
ISA
ISM
NAS
7 references
retrieved
8 April 2019
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
NAS
retrieved
8 April 2019
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
ISM
retrieved
8 April 2019
stated in
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
ISA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IEA
retrieved
8 April 2019
stated in
Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IDA
retrieved
8 April 2019
stated in
The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP)
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IBA
cell component
nucleus
determination method or standard
IEA
ISS
IDA
7 references
retrieved
5 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P18848
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
determination method or standard
ISS
retrieved
5 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P18848
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
determination method or standard
IEA
retrieved
5 June 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
determination method or standard
IEA
retrieved
5 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
determination method or standard
IEA
retrieved
5 June 2018
stated in
ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
determination method or standard
IDA
retrieved
5 June 2018
stated in
The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP)
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
determination method or standard
IDA
retrieved
5 June 2018
stated in
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P18848&geneProductId=UniProtKB:P18848
determination method or standard
IDA
nucleus
determination method or standard
IBA
IDA
IEA
ISS
8 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P18848
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
ISS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P18848
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IEA
retrieved
8 April 2019
stated in
ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IDA
retrieved
8 April 2019
stated in
The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP)
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IDA
retrieved
8 April 2019
stated in
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IBA
biological process
positive regulation of transcription by RNA polymerase II
determination method or standard
IEA
ISS
IDA
IMP
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P18848
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
ISS
retrieved
8 April 2019
stated in
The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism
GOA
curator
UniProt
UniProt protein ID
P18848
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IEA
retrieved
8 April 2019
stated in
TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IDA
retrieved
8 April 2019
stated in
C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IDA
retrieved
8 April 2019
stated in
The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP)
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IDA
positive regulation of transcription, DNA-templated
determination method or standard
IEA
ISS
IMP
IDA
NAS
6 references
retrieved
8 April 2019
stated in
Functional interaction of the HTLV-1 transactivator Tax with activating transcription factor-4 (ATF4)
GOA
curator
UniProt
UniProt protein ID
P18848
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
NAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P18848
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
ISS
retrieved
8 April 2019
stated in
ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene
GOA
curator
UniProt
UniProt protein ID
P18848
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IEA
retrieved
8 April 2019
stated in
TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death
GOA
curator
UniProt
UniProt protein ID
P18848
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IDA
retrieved
8 April 2019
stated in
C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene
GOA
curator
UniProt
UniProt protein ID
P18848
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18848
determination method or standard
IDA

Identifiers

Freebase ID
/m/03cwkv6
0 references
 
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                  Retrieved from "https://www.wikidata.org/w/index.php?title=Q21102119&oldid=2022918263"