SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator (Q24626329)

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9 February 2020

title

SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator (English)

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9 February 2020

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8

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9 February 2020

author name string

Han Dai

1

1 reference

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9 February 2020

Lauren Kustigian

2

1 reference

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9 February 2020

David Carney

3

1 reference

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9 February 2020

April Case

4

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9 February 2020

Thomas Considine

5

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9 February 2020

Basil P Hubbard

6

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9 February 2020

Robert B Perni

7

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9 February 2020

Bruce Szczepankiewicz

9

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9 February 2020

George P Vlasuk

10

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9 February 2020

Ross L Stein

11

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9 February 2020

language of work or name

English

0 references

publication date

11 August 2010

1 reference

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Journal of Biological Chemistry

9 February 2020

number of pages

9

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based on heuristic

inferred from page(s)

published in

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9 February 2020

volume

285

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9 February 2020

issue

43

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9 February 2020

page(s)

32695-32703

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SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

9 February 2020

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Resveratrol is not a direct activator of SIRT1 enzyme activity

7 April 2017

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Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3

7 April 2017

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Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

7 April 2017

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Mechanism of human SIRT1 activation by resveratrol

7 April 2017

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Substrate-specific activation of sirtuins by resveratrol

7 April 2017

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

7 April 2017

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Allosteric Activation of the Hydrolysis of Specific Substrates by Chymotrypsin

7 April 2017

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ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety

7 April 2017

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Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions

7 April 2017

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Mammalian sirtuins: biological insights and disease relevance

7 April 2017

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Discovery, structure-activity relationships, pharmacokinetics, and efficacy of glucokinase activator (2R)-3-cyclopentyl-2-(4-methanesulfonylphenyl)-N-thiazol-2-yl-propionamide (RO0281675).

7 April 2017

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Sirt1 activation protects the mouse renal medulla from oxidative injury

27 September 2017

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Resveratrol, sirtuins, and the promise of a DR mimetic

27 September 2017

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Turning enzymes ON with small molecules

27 September 2017

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SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity

27 September 2017

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SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells

27 September 2017

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SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity

27 September 2017

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Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice.

27 September 2017

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27 September 2017

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PubMed

https://pubmed.ncbi.nlm.nih.gov/20702418

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.133892

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20702418%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

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9 February 2020

PubMed publication ID

20702418

2 references