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    Sustain Releas 2

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    ripusudan1532
    Sustained release drug delivery systems aim to deliver drugs at a rate dictated by the body's needs over an extended period of time. Conventional dosage forms have drawbacks like needing frequent administration, uncontrolled drug level fluctuations, and difficulty achieving steady drug levels. Sustained release systems address these issues by reducing dosing frequency, maintaining more uniform drug concentrations, and improving patient compliance and convenience. Some drugs that are formulated as sustained release include alprazolam, bupropion, and metformin. While sustained release offers benefits, it also has potential disadvantages such as decreased bioavailability and issues with dose dumping or retrieval in emergencies.

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    Sustain Releas 2

    Uploaded by

    ripusudan1532
    7 views9 pages
    Sustained release drug delivery systems aim to deliver drugs at a rate dictated by the body's needs over an extended period of time. Conventional dosage forms have drawbacks like needing frequent administration, uncontrolled drug level fluctuations, and difficulty achieving steady drug levels. Sustained release systems address these issues by reducing dosing frequency, maintaining more uniform drug concentrations, and improving patient compliance and convenience. Some drugs that are formulated as sustained release include alprazolam, bupropion, and metformin. While sustained release offers benefits, it also has potential disadvantages such as decreased bioavailability and issues with dose dumping or retrieval in emergencies.

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    Sustain Releas 2 (2)

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    Sustained release drug delivery systems aim to deliver drugs at a rate dictated by the body's needs over an extended period of time. Conventional dosage forms have drawbacks like needing frequent administration, uncontrolled drug level fluctuations, and difficulty achieving steady drug levels. Sustained release systems address these issues by reducing dosing frequency, maintaining more uniform drug concentrations, and improving patient compliance and convenience. Some drugs that are formulated as sustained release include alprazolam, bupropion, and metformin. While sustained release offers benefits, it also has potential disadvantages such as decreased bioavailability and issues with dose dumping or retrieval in emergencies.

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    © All Rights Reserved
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    Download as pptx, pdf, or txt
    7 views9 pages

    Sustain Releas 2

    Uploaded by

    ripusudan1532
    Sustained release drug delivery systems aim to deliver drugs at a rate dictated by the body's needs over an extended period of time. Conventional dosage forms have drawbacks like needing frequent administration, uncontrolled drug level fluctuations, and difficulty achieving steady drug levels. Sustained release systems address these issues by reducing dosing frequency, maintaining more uniform drug concentrations, and improving patient compliance and convenience. Some drugs that are formulated as sustained release include alprazolam, bupropion, and metformin. While sustained release offers benefits, it also has potential disadvantages such as decreased bioavailability and issues with dose dumping or retrieval in emergencies.

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    © All Rights Reserved
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    Download as pptx, pdf, or txt
    of 9

    SUSTAINED RELEASE

    DOSAGE FORM

    SUBMITTED BY :- RIPU SUDAN


    An ideal drug delivery system should aid in the
    optimization of drug therapy by delivering an
    appropriate amount to the intended site and at a
    desired rate.

    Hence, the DDS should deliver the drug at a rate


    dictated by the needs of the body over the period of
    treatment. An oral drug delivery system providing a
    uniform drug delivery can only partly satisfy
    therapeutic and biopharmaceutical needs, as it doesn’t
    take in to account the site specific absorption rates
    within the gastrointestinal tract (GIT).

    ORAL DRUG DELIVERY SYSTEM


     1. A drug with short biological half life which needs a close
    succession administration is required, so it may increase the
    missing of dosage form leads to Poor patient compliance.

     2. The uncontrollable fluctuation of drug level may leads to


    either below effective range or over the effective range.

     3. Plasma concentration verses time profile of dosage form


    and it’s difficult to achieve the steady state active drug level.

     4. The rise and fall of drug levels it may give to


    accumulation of adverse effects especially for a drug having
    less therapeutic index.

    Drawbacks associated with


    conventional dosage forms:
     The main destination of any drug delivery system is to furnish a
    contributing to quantity of a drug to a suitable region in the body
    and that the required drug concentration can be attained
    promptly and then being maintained.

     The drug delivery system should distribute a drug at a rate


    dictated by the require of the body for particular length of time.
    Regarding this existing points there are two important aspects to
    delivery system, said as, spatial placement and temporal delivery.

     Spatial placement connected to targeting a drug to particular


    organ, tissues, cells, or even sub cellular area; whereas temporal
    delivery system deals to controlling the rate of dosage form to the
    targeting region

    Sustained release drug delivery


    system:
    Alprazolam, bupropion, clomipramine,
    quetiapine, Metformin and etc.

    Some drugs work as Sustained


    Release
     1. Reduction in dosing frequency.
     2. Reduced fluctuation in circulating drug levels.
     3. Increased patient convenience and compliance.
     4. Avoidance of night time dosing.
     5. More uniform effect.
     6. Maximum utilization of drug.
     7. Reduction in GI irritation and other side
    effects.
     8. Reduction in health care cost through improved
    therapy.
     9. Improve bioavailability of some drugs

    Some advantages are as follows


     1. Decreased systemic availability in comparison to immediate
    release conventional dosage form. This may be due to
    Incomplete release Increased first-pass metabolism,
    increased instability Site specific absorption, pH dependant
    solubility, etc.

     2. Poor in vitro-in vivo correlation.

     3. Possibility of dose dumping.

     4. Retrival of drug is difficult in case of toxicity, poisoning, or


    hypersensitivity reactions.

     5. Higher cost of formulation.

    Disadvantages of sustained
    release drug delivery system
    THANK YOU

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