Group 2 Glycolipids

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GLYCOLIPIDS

BY GROUP 2
BBT 1209 _ MACROMOLECULES (PROTEINS, LIPIDS,
CARBOHYDRATES)
GLYCOLIPIDS

 Glycolipids are glycoconjugates.


 Glycoconjugates are glycans that are covalently
linked with various chemical species such as
lipids, proteins, peptides and other compounds.
A glycolipid is an oligosaccharide-containing lipid
molecule.
 They are found predorminatly on the outer
surface of plasma membrane.
GLYCOLIPIDS

 Their main role is to maintain stability of the membrane


and to facilitate cellular recognition.
 Glycolipids are lipids with a carbohydrate attached by a
glycosidic bond.
 The most common lipids in the cellular membranes are
glycerolipids and sphingolipids. Sphingolipids are a class of
lipids with a sphingoid bases, which are a set of aliphatic
amino alcohols. For example sphingosine.
METABOLISM OF GLYCOLIPIDS

 GLYCOSYLTRANSFERASES; these are enzymes that


link the saccharide to the lipid molecule and
assemble the correct oligosaccharide.

 GLYCOSIDE HYDROLASES; these are enzymes that


modify the oligosaccharide structure of the glycan
after it has been added to the lipid. They can also
remove glycans from glycolipids.
FUNCTIONS OF GLYCOLIPIDS

 CELL MEMBRANE STABILITY


The carbohydrate chains project like antennae into
the watery fluids surrounding the cell where they
form hydrogen bonds with the water molecules and
so help stabilize the membrane structure.

The carbohydrate chains form a sugary coating


called glycocalyx.
FUNCTIONS OF GLYCOLIPIDS

 IMMUNE RESPONSE
The carbohydrate chains help the glycolipids to act as
receptor molecules, which bind with particular substances at
the cell surface.
Some glycolipids act as cell markers or antigens, allowing
cell-cell recognition.
Each type of cell has its own type of antigen.
For example the ABO blood group antigens are glycolipids
and glycoproteins.
FUNCTIONS OF GLYCOLIPIDS

 CELL RECOGNITION
They facilitate interactions between cells, allowing them to
connect and form tissues.
They bind to molecules that are parts of the structure
engulfed by the cell surface.
They are involved in binding cells to other cells in tissues
and organs in animals.
They serve as recognition sites during cell-cell recognition.
FUNCTIONS OF GLYCOLIPIDS

 EXTRACELLULAR ENVIRONMENT
They are found on the surface of all eukaryotic cell
membranes, glycolipids extend into the
extracellular matrix.

Carbohydrate receptors, the saccharides of


glycolipids bind to specific complementary
carbohydrates or lectins on neighboring cells.

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