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    The document summarizes the mechanism of action and treatment of Ebolavirus. It discusses that Ebolavirus causes hemorrhagic fever and is transmitted through direct contact with bodily fluids. It enters immune cells through macropinocytosis and interacts with NPC1 proteins after reaching the cytoplasm. This allows the virus to replicate its genetic material and exit infected cells. Potential monoclonal antibody treatments discussed include ZMapp and mAb114. However, developing treatments is challenging due to the virus's small size and rapid evolution.

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    The document summarizes the mechanism of action and treatment of Ebolavirus. It discusses that Ebolavirus causes hemorrhagic fever and is transmitted through direct contact with bodily fluids. It enters immune cells through macropinocytosis and interacts with NPC1 proteins after reaching the cytoplasm. This allows the virus to replicate its genetic material and exit infected cells. Potential monoclonal antibody treatments discussed include ZMapp and mAb114. However, developing treatments is challenging due to the virus's small size and rapid evolution.

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    The document summarizes the mechanism of action and treatment of Ebolavirus. It discusses that Ebolavirus causes hemorrhagic fever and is transmitted through direct contact with bodily fluids. It enters immune cells through macropinocytosis and interacts with NPC1 proteins after reaching the cytoplasm. This allows the virus to replicate its genetic material and exit infected cells. Potential monoclonal antibody treatments discussed include ZMapp and mAb114. However, developing treatments is challenging due to the virus's small size and rapid evolution.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    9 views15 pages

    Report 2

    Uploaded by

    edan Marvil
    The document summarizes the mechanism of action and treatment of Ebolavirus. It discusses that Ebolavirus causes hemorrhagic fever and is transmitted through direct contact with bodily fluids. It enters immune cells through macropinocytosis and interacts with NPC1 proteins after reaching the cytoplasm. This allows the virus to replicate its genetic material and exit infected cells. Potential monoclonal antibody treatments discussed include ZMapp and mAb114. However, developing treatments is challenging due to the virus's small size and rapid evolution.

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    of 15

    Ebolavirus

    mechanism of action
    Correction….
    Monoclonal Antibodies for the virus:
     Zmapp
    o Combination of 3 proteins
     mAb114
    o Derived from the Ebola survivor
    Review

    Filoviridae: causes
    hemorrhagic fever
    Zoonotic virus
    Transmitted by direct
    contact to bodily fluid
    Death by bleeding
    Coat
    Cell attachment & Invasion

    Serves different function with


    3 configurations

    Binds/ Organizes the Viral


    RNA into a Rod shape

    Maintains the structure of


    nucleocapsid
    Suppresses the immune
    system

    RNA polymerase
    Makes copies of viral RNA
    with VP35
    • EBOV is make use of the process
    called macropinocytosis.
    • EBOV GP reacts with the protein
    receptors (TIM proteins) of the
    immune cells that detects debris.

    Macropinocytosis

    Immune cells
    • EBOV is engulphed.
    • EBOV GP is digested into GP2.

    Lysosome
    • Upon reaching cytoplasm,
    EBOV GP2 interacts with the
    Niemann-Pick C1 (NPC1) NPC1 proteins
    proteins.
    EBOV is able to detect its
    location through NPC1
    proteins.
    • EBOV viral membrane fuses with the
    endosomal membrane upon
    reaching cytoplasm.
    • Releases its viral genetical material.
    • Replication of the genetic material.
    • The genetic material will undergo
    transcription and translation
    process.
    Viral budding (cell exit)
    The virus exits the infected cell from:
    Intracellular membrane
    Multivesicular bodies
    Plasma membrane
    Target cells of EBOV
    First targets for infection: Followed by:
    Monocytes/Macrophage Fibroblasts
     Dendritic cells Hepatocytes
    Adrenal cells
    Epithelial cells
    EBOV induced pathogenic
    events
    Why so difficult for the cure?
    • Too small (virus).
    • Less target since it only makes few proteins.
    • They evolve quickly.
    • Making or studying EBOV require biosafety level 4
    laboratories.
    • Relatively few people are infected and fewer
    survivors.
    References
    • https://www.youtube.com/watch?v=6w-NTWU6CwY
    • https://www.sciencedaily.com/releases/2019/03/190326132746.htm
    • Falasca, L., Agrati, C., Petrosillo, N., Di Caro, A., Capobianchi, M. R., Ippolito, G., &
    Piacentini, M. (2015). Molecular mechanisms of Ebola virus pathogenesis: focus
    on cell death. Cell Death & Differentiation, 22(8),
    1250–1259. doi:10.1038/cdd.2015.67 
    • https://www.livescience.com/46479-ebola-treatment-cure.html
    • https://www.nih.gov/news-events/nih-research-matters/ebola-antibody-treatment
    -tested-people
    • https://www.sciencedaily.com/releases/2019/03/190326132746.htm
    Recommended to watch
    • https://www.youtube.com/watch?v=3IFX9LHcnyg
    • https://www.youtube.com/watch?v=BHQUp-R0q9U

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