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    9 Cushing's Disease

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    Hanen Zedan
    Cushing's disease/syndrome is a hormonal disorder caused by prolonged high levels of cortisol due to tumors in the pituitary, adrenal glands, or lungs. It results in weight gain, fatty deposits, skin changes, high blood pressure, and other signs and symptoms. Diagnosis involves tests to measure cortisol and ACTH levels. Treatment options include medications to reduce cortisol production, surgery to remove tumors, and in severe cases, bilateral adrenalectomy. Complications can include adrenal carcinoma, Addisonian crisis, and adverse effects of excess cortisol.

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    9 Cushing's Disease

    Uploaded by

    Hanen Zedan
    4 views16 pages
    Cushing's disease/syndrome is a hormonal disorder caused by prolonged high levels of cortisol due to tumors in the pituitary, adrenal glands, or lungs. It results in weight gain, fatty deposits, skin changes, high blood pressure, and other signs and symptoms. Diagnosis involves tests to measure cortisol and ACTH levels. Treatment options include medications to reduce cortisol production, surgery to remove tumors, and in severe cases, bilateral adrenalectomy. Complications can include adrenal carcinoma, Addisonian crisis, and adverse effects of excess cortisol.

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    Cushing's disease/syndrome is a hormonal disorder caused by prolonged high levels of cortisol due to tumors in the pituitary, adrenal glands, or lungs. It results in weight gain, fatty deposits, skin changes, high blood pressure, and other signs and symptoms. Diagnosis involves tests to measure cortisol and ACTH levels. Treatment options include medications to reduce cortisol production, surgery to remove tumors, and in severe cases, bilateral adrenalectomy. Complications can include adrenal carcinoma, Addisonian crisis, and adverse effects of excess cortisol.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    4 views16 pages

    9 Cushing's Disease

    Uploaded by

    Hanen Zedan
    Cushing's disease/syndrome is a hormonal disorder caused by prolonged high levels of cortisol due to tumors in the pituitary, adrenal glands, or lungs. It results in weight gain, fatty deposits, skin changes, high blood pressure, and other signs and symptoms. Diagnosis involves tests to measure cortisol and ACTH levels. Treatment options include medications to reduce cortisol production, surgery to remove tumors, and in severe cases, bilateral adrenalectomy. Complications can include adrenal carcinoma, Addisonian crisis, and adverse effects of excess cortisol.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 16

    Cushing's

    Disease/Syndrome
    Introduction
    Cushing's Disease/ Cushing's Syndrome: Cushing's is a hormonal disorder
    caused by prolonged exposure of the body's tissues to high levels of the
    hormone cortisol. Your adrenal glands, which are right above your kidneys,
    release cortisol when they receive a chemical message from your pituitary
    gland. The message comes in the form of adrenocorticotrophic hormone
    (ACTH), which travels through the bloodstream. The pituitary gland is
    ."known as the "Master gland of the body
    Definition

    is a condition in which the plasma cortisol level is elevated, causing signs


    and symptoms of Hypercortisolism.
    Causes of Cushing's

    • A benign tumor of the adrenal gland .


    • A benign tumor of the pituitary gland .
    • A benign tumor of the lung or other organ .
    • Extensive use of cortisone medication .
    • Administration of ACTH or Corticosteroids.
    • Primary hyperplasia of both adrenal gland.
    • Excessive secretion of adrenal androgen.
    • Exogenous Glucocorticoid administration.
    :Pathophysiology
    Due to etiological factor

    .Normal feedback mechanisms that control adreno cortical function are ineffective

    Resulting in excess secretion of adrenal cortical hormones Inadequate amount of


    adrenal cortical hormones in

    secretion

    Hypercortisolism
    signs and symptoms

    • The signs and symptoms of Cushing syndrome can vary depending on the levels of excess
    cortisol.
    • Common signs and symptoms of Cushing syndrome
    • Weight gain and fatty tissue deposits, particularly around the midsection and upper back, in the
    face (moon face), and between the shoulders (buffalo hump)
    • Pink or purple stretch marks (striae) on the skin of the abdomen, thighs,
    • breasts and arms Thinning,
    • fragile skin that bruises easily
    • Slow healing of cuts, insect bites and infections Acne
    • Signs and symptoms women with Cushing syndrome may experience
    Thicker or more visible body and facial hair (hirsutism)
    • Irregular or absent menstrual periods
    • Signs and symptoms men with Cushing syndrome may experience
    • Decreased sex drive Decreased
    • fertility Erectile dysfunction
    • Other possible signs and symptoms of Cushing syndrome
    • Severe fatigue
    • Muscle weakness
    • Depression, anxiety and irritability
    • Loss of emotional control
    • Cognitive difficulties
    • New or worsened high blood pressure
    • Headache
    • Infections
    • Skin darkening
    • Bone loss, leading to fractures over time
    • In children, impaired growth
    Diagnostic Evaluation

    History Collection Physical Examination


    •CT Scan and USG
    Radio-Immuno Assay of plasma ACTH
    Corticotropin releasing factor (CRF) Stimulation Test.
    • Dexamethasone suppression Test
     • Blood samples X-rays of the skull
    • Reduced eosinophils level
    • Excessive Plasma cortisol level
    Medical Management

    • Mitotane = An agent toxic to the adrenal cortex.


    • • Metropine = To control (steroid hyper secretion) who do not respond to
    mitotane therapy.
    • Amino-glutethimide = Effectively Blocking cortisol production
    • Protein anabollic steroids may be given to facilitate is required (protein
    and potassium replacement)
    Surgical Management

    i) Trans spheroidal adenomectomy orHypophysectomy: = Removal of


    pituitary gland
    ii) ii) Trans frontal Craniotomy: = It is necessary when pituitary tumor is
    enlarge.
    iii) iii) Bilateral Adrenalectomy:= Hyperplasia of adrenals
    Complication

    • Adrenal Carcinoma
    • Addisonian crisis
    • Adverse effects of Adreno - cortical activity.
    Nursing Diagnosis
    • Impaired skin integrity r/t altered healing and edema
    • Self care deficit r/t muscle wasting and fatigue.
    • Anxiety r/t surgery
    • Risk for Injury to surgical procedure.
    • Self-Esteem disturbance related to altered physical appearance.

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