Typhoid Fever: Prepared By: Joycemay G. Andaya

Download as pptx, pdf, or txt
Download as pptx, pdf, or txt
You are on page 1of 14

Typhoid Fever

Prepared by: Joycemay G. Andaya


Pathophysiology
• CAUSATIVE AGENT
▫ Salmonella typhi

• MODE OF TRANSMISSION:

Contaminated Contaminated sewage Poor hand hygiene


food or water (poor water filtration)
Pathophysiology

Bacteria invade the


End of incubation period,
gallbladder, biliary
bacilli enter bloodstream
Ingest contaminated food system and lymphatic
(Bacteremia phase)
tissue of the bowel and
(Onset of Typhoid Fever)
multiply in high number

Intact with enterocytes &


M cells (ileal Peyer’s
Ingested bacilli invade Then pass into the
patches) during the 1-3
small intestinal mucosa intestinal tract
week of incubation
period (Diarrhea)

Taken up by macrophage s. Typhi multiply in the


& transported to regional intestinal lymphoid
lymph node tissue
Epidemiology
• Prevalence
Epidemiology
• Prevalence

Majority of the
confirmed cases
were male (29 or
56%). Most affected
age group is 10 to 19
years old (14 or
27%)
Epidemiology
• Prevalence
▫ The distribution of cases for 2019 compared to
epidemic and alert thresholds.
Epidemiology
• Geographical distribution

There was a 41& increase of


confirmed typhoid fever from
37 cases in 2018 to 52 cases in
2019. Most of the reported
cases were from the following
regions:
• ARMM (10 or 19 %)
• Region VII (9 OR 17%)
• Region VIII (9 or 17%)
• Region IX (9 or 17%)
Risk factors
• Work in or travel to areas where typhoid fever is
established (endemic)
• Work as a clinical microbiologist handling
Salmonella typhi bacteria
• Have close contact with someone who is infected
or has recently been infected with typhoid fever
• Drink water contaminated by sewage that
contains Salmonella typhi
DOC/1st line of treatment (Vaccines)
• Two typhoid vaccines are currently available:
▫ Vi-PS vaccine (IM) - A polysaccharide vaccine
based on the purified Vi-antigen
▫ Ty21a vaccine - A live attenuated oral vaccine (also
available in capsules)
DOC/1st line of treatment
(Vaccines)
• Antibiotics for Uncomplicated Typhoid fever
DOC/1st line of treatment
(Vaccines)
• •Antibiotics
Antibioticsfor
forComplicated
ComplicatedTyphoid
Typhoidfever
fever
DOC/1st line of treatment
(Vaccines)
• Multi-drug resistant typhoid fever (MDRTF)
Govt. program on disease prevention
and control
• According to DOH
▫ Boil water for drinking. (Upon reaching boiling point,
extend boiling for two or more minutes) or
▫ Do water chlorination
▫ Cook food well and always use food cover to prevent flies
and other insects from contaminating them.
▫ Wash thoroughly all vegetables and fruits especially those
that are eaten raw.
▫ Avoid eating street vended foods.
▫ Wash hands with soap and water after using the toilet and
before eating.
▫ Keep surrounding clean to prevent breeding of flies.
References
• https://www.doh.gov.ph/node/286
• https://www.slideshare.net/yuyuricci/enteric-fe
ver-typhoid-fever
• https://www.doh.gov.ph/sites/default/files/stat
istics/2019_Monthly_FWBD_Report_N2.pdf
• http://thepafp.org/website/wp-content/uploads
/2017/05/2017-Typhoid-fever-in-Adults.pdf

You might also like