Scribd Logo
Upload

Welcome to Scribd!

  • 44 views

    Drugs Used in Bronchial Asthma: Dr. Mozna Talpur

    Uploaded by

    Shahid Hameed
    The document discusses drugs used to treat bronchial asthma, classified as bronchodilators or anti-inflammatories. Bronchodilators like salbutamol relax airway smooth muscle using various mechanisms of action. Anti-inflammatories include mast cell stabilizers, leukotriene pathway inhibitors, and corticosteroids which reduce inflammation in different ways. Each drug class is described in 1-2 sentences with their mechanisms of action, clinical uses, and potential side effects.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd

    Drugs Used in Bronchial Asthma: Dr. Mozna Talpur

    Uploaded by

    Shahid Hameed
    44 views15 pages
    The document discusses drugs used to treat bronchial asthma, classified as bronchodilators or anti-inflammatories. Bronchodilators like salbutamol relax airway smooth muscle using various mechanisms of action. Anti-inflammatories include mast cell stabilizers, leukotriene pathway inhibitors, and corticosteroids which reduce inflammation in different ways. Each drug class is described in 1-2 sentences with their mechanisms of action, clinical uses, and potential side effects.

    Original Title

    bronchial asthman

    Copyright

    © © All Rights Reserved

    Available Formats

    PPTX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    The document discusses drugs used to treat bronchial asthma, classified as bronchodilators or anti-inflammatories. Bronchodilators like salbutamol relax airway smooth muscle using various mechanisms of action. Anti-inflammatories include mast cell stabilizers, leukotriene pathway inhibitors, and corticosteroids which reduce inflammation in different ways. Each drug class is described in 1-2 sentences with their mechanisms of action, clinical uses, and potential side effects.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    44 views15 pages

    Drugs Used in Bronchial Asthma: Dr. Mozna Talpur

    Uploaded by

    Shahid Hameed
    The document discusses drugs used to treat bronchial asthma, classified as bronchodilators or anti-inflammatories. Bronchodilators like salbutamol relax airway smooth muscle using various mechanisms of action. Anti-inflammatories include mast cell stabilizers, leukotriene pathway inhibitors, and corticosteroids which reduce inflammation in different ways. Each drug class is described in 1-2 sentences with their mechanisms of action, clinical uses, and potential side effects.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 15

    DRUGS USED IN

    BRONCHIAL
    ASTHMA
    Dr. Mozna Talpur

    1
    DRUGS USED IN BRONCHIAL
    ASTHMA
    Classified as brochodilators or anti-inflammatory:
     Anti-inflammatory
     Brochodilators  Mast cell stabilizer:
     Cromolyn
     B2-Agonists:
     Nedocromil
     Salbutamol
     LT Pathway inhibitors:
     Terbutaline
     Zileuton ( 5-LOX
     Salmetrol
    inhibitors)
     PDE inhibitors:  Zafirleukast
     Theophylline  Monteleukast
     Aminophylline  Corticosteroids:
     Anti muscaranic:  Beclomethasone

     Ipratropium  Budesonide

    2
    B2RECEPTOR AGONIST MOA
    B2 Receptor + Agonists

    adenylyl cyclase

    ATP →cAMP

    Biological process

    ↑ K+ influx ↓ Ca2+influx

    Dephosphorylation of myocin light chain

    Broncho relaxation
     Clinical uses:
     Used as SOS in bronchial asthma and COPD
     Toxicity:
     Tachycardia
     Cardiac arrhythmias
     Tachyphylaxis
     Tolerance
     Postural hypotension.
     Paralytic ileus

    4
    PDE INHIBITORS

    5
    MOA
     Inhibits enzyme phosphodiestrase which is
    responsible for degradation of cAMP into
    adenosine.
     Adenosine causes bronchoconstriction while
    cAMP causes bronchodilation.

    6
     Clinical Uses:  Convulsion
     Asthma
     Death
     CVS:
     COPD
     +ve inotropic
     Sk Muscles:  +ve Chronotropic
     Strengthens contraction.  ↑se peripheral resistance
     Reverses fatigue of
    Diaphragm in pt with
    COPD  GIT:
     ↑se secretion of gastric
     Side effects: acid
     CNS
     Nervousness, Insomnia
     Tremors

    7
    ANTI-MUSCARANIC
     Clinical uses:
     Asthma:
     Maintenance therapy.
     Enhances bronchodilation produced by beta agonists.
     COPD.

    8
    LEUKOTRIENS PATHWAY
    INHIBITORS
     Leukotriene Inhibitor Drugs:
     Zileuton
     MOA: prevent synthesis of leukotriene or block the
    enzyme 5-LOX.
     Clinical Use:
     Control of chronic asthma
     Aspirin induced asthma.
     Adverse effects:
     Nausea, diarrhea, rash, headache, increased liver
    enzymes, fever, dark urine, clay-colored stools, or
    jaundice (signs of liver toxicity)

    9
    LEUKOTRIENS RECEPTOR
    BLOCKERS
     MOA: blocks the LTs receptors.
     Clinical uses:
     Asthma.
     Adverse reaction:
     Churg strauss syndrome:
     Systemic vasculitis, worsening of asthma, Pulmonary
    infiltrates and oesinophilia.

    10
    CORTICOSTEROIDS
     Enter cells where they combine with steroid
    receptors in cytoplasm.
     Combination enters nucleus where it controls
    synthesis of protein, including enzymes that
    regulate vital cell activities over a wide range of
    metabolic functions including all aspects of
    inflammation.
     Formation of a protein that inhibits the enzyme
    phospholipase A2 which is needed to allow the
    supply of arachidonic acid.
     Latter is essential for the formation of
    inflammatory mediators of asthma.

    11
    12
    13
     Clinical uses:
     Asthma and COPD as maintenance therapy.
     Side effects:
     Orophryngeal candidiasis.
     Hoarseness of voice.
     Osteoporosis.
     Cataract.
     Slow growth rate in children
     Delayed puberty.
     Thinning of skin.

    14
    MAST CELL STABILIZERS
     MOA:
     Interferes with antigen-antibody reaction of mast cells
     Clinical use:
     Prophylactic control of chronic asthma
     Rhinoconjunctivitis (allergic)
     Adverse effects:
     Nasal stinging
     Nasal irritation
     Headache
     Bad taste
     Allergic reaction

    15

    You might also like